scholarly journals The prognostic role of lymphovascular invasion and lymph node metastasis in perihilar and intrahepatic cholangiocarcinoma

HPB ◽  
2020 ◽  
Vol 22 ◽  
pp. S264-S265
Author(s):  
J. Bednarsch ◽  
Z. Czigany ◽  
I. Amygdalos ◽  
D Morales Santana ◽  
M. Den Dulk ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Intrahepatic Cholangiocarcinoma ◽  
Lymphovascular Invasion ◽  
Prognostic Role ◽  
Node Metastasis

The prognostic role of lymphovascular invasion and lymph node metastasis in perihilar and intrahepatic cholangiocarcinoma

2019 ◽  
Vol 45 (8) ◽  
pp. 1468-1478 ◽  
Author(s):  
Georg Lurje ◽  
Jan Bednarsch ◽  
Zoltan Czigany ◽  
Isabella Lurje ◽  
Ivana Katharina Schlebusch ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Intrahepatic Cholangiocarcinoma ◽  
Lymphovascular Invasion ◽  
Prognostic Role ◽  
Node Metastasis

scholarly journals Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review

Head & Neck ◽  
2020 ◽  
Author(s):  
Orlando Guntinas‐Lichius ◽  
Jovanna Thielker ◽  
K. Thomas Robbins ◽  
Kerry D. Olsen ◽  
Ashok R. Shaha ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Prognostic Role ◽  
Parotid Cancer ◽  
Node Metastasis

scholarly journals Successful Treatment of stage IIIb intrahepatic Cholangiocarcinoma After Neoadjuvant Therapy With PD-1blockade Camrelizumab: A Case Report and Review of Literature

2021 ◽  
Author(s):  
Shuguang Zhu ◽  
Haibo Li ◽  
Jianwen Zhang ◽  
Chunhui Qiu ◽  
Tianxing Dai ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Neoadjuvant Therapy ◽  
Successful Treatment ◽  
Intrahepatic Cholangiocarcinoma ◽  
Review Of Literature ◽  
Nccn Guidelines ◽  
Node Metastasis

Abstract Prognosis of ICC with lymph node metastasis is poor. And the feasibility of operation is uncertain, which is a contraindication in NCCN guidelines. In addition, in the neoadjuvant therapy of ICC, the role of immunotherapy is not clear. We describe a case of ICC with lymph node metastasis was successfully treated with neoadjuvant therapy.

scholarly journals The prognostic role of c-MYC amplification in schistosomiasis-associated colorectal cancer

2020 ◽  
Vol 50 (4) ◽  
pp. 446-455 ◽  
Author(s):  
Weiyu Pan ◽  
Weixia Wang ◽  
Jie Huang ◽  
Kui Lu ◽  
Sinian Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Positive Lymph Node ◽  
Prognostic Role ◽  
Full Cohort ◽  
Poor Prognostic Factor ◽  
Node Metastasis ◽  
Significant Difference

Abstract Objective The purpose of this study was to explore the prognostic role of c-MYC amplification in colorectal cancer, particularly in schistosomiasis-associated colorectal cancer. Methods Three hundred and fifty four cases of colorectal cancer, which were from Qingpu Branch of Zhongshan Hospital affiliated to Fudan University, were retrospectively analyzed in a tissue microarray (TMA) format, with fluorescence in situ hybridization (FISH) assay and immunohistochemistry (IHC). Results c-MYC gene amplification was found in 14.1% (50 out of 354) of patients with colorectal cancer and was correlated with old age (P = 0.028), positive lymph node metastasis (P = 0.004) and advanced stage tumors (P = 0.002). The overexpression of c-MYC was closely associated with the amplification status (P = 0.023). Kaplan–Meier survival curves for overall survival (OS) showed a statistically significant difference for patients with c-MYC amplification in full cohort of colorectal cancer, stage III-IV set and patients with lymph node metastasis (P = 0.002, 0.034, 0.012, respectively). Further analysis found c-MYC amplification associated with poorer survival in the subgroup of colorectal cancer with schistosomiasis (CRC-S, P < 0.001), but not in colorectal cancer without schistosomiasis (CRC-NS, P = 0.155). By multivariate analysis, c-MYC amplification was an independent poor-prognostic factor in CRC-S set (P = 0.046). Conclusions Our study firstly found c-MYC amplification could predict poor prognosis in schistosomiasis-associated colorectal cancer, but not in colorectal cancer without schistosomiasis.

scholarly journals Intrahepatic Cholangiocarcinoma with Lymph Node Metastasis: Treatment-Related Outcomes and the Role of Tumor Genomics in Patient Selection

2021 ◽  
pp. clincanres.0412.2021
Author(s):  
Joshua S. Jolissaint ◽  
Kevin C. Soares ◽  
Kenneth P. Seier ◽  
Ritika Kundra ◽  
Mithat Gonen ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Patient Selection ◽  
Intrahepatic Cholangiocarcinoma ◽  
Node Metastasis

Abstract PS1-54: Risk factors for lymph node metastasis and the role of SLNB in microinvasive breast cancer

2021 ◽  
Author(s):  
Pill Sun Paik ◽  
Min Kyung Cho ◽  
Juneyoung Ahn ◽  
Chang Ik Yoon ◽  
Tae-Kyung Yoo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Node Metastasis ◽  
Microinvasive Breast Cancer

scholarly journals Intrahepatic cholangiocarcinoma patients without indications of lymph node metastasis not benefit from lymph node dissection

Oncotarget ◽  
2017 ◽  
Vol 8 (69) ◽  
pp. 113817-113827 ◽  
Author(s):  
Jie Hu ◽  
Fei-Yu Chen ◽  
Kai-Qian Zhou ◽  
Cheng Zhou ◽  
Ya Cao ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lymph Node Dissection ◽  
Intrahepatic Cholangiocarcinoma ◽  
Node Dissection ◽  
Node Metastasis

scholarly journals The role of microvessel density, lymph node metastasis, and tumor size as prognostic factors of distant metastasis in colorectal cancer

2017 ◽  
Vol 13 (6) ◽  
pp. 4327-4333 ◽  
Author(s):  
Tomonari Cho ◽  
Eisuke Shiozawa ◽  
Fumihiko Urushibara ◽  
Nana Arai ◽  
Toshitaka Funaki ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Distant Metastasis ◽  
Microvessel Density ◽  
Tumor Size ◽  
Node Metastasis

scholarly journals FGFR3 promotes the growth and malignancy of melanoma by influencing EMT and the phosphorylation of ERK, AKT, and EGFR

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Lei Li ◽  
Shuai Zhang ◽  
Hao Li ◽  
Haiyan Chou
Keyword(s):  
Cell Proliferation ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Colony Formation ◽  
Caspase 3 ◽  
Growth Factor Receptor ◽  
Invasion And Migration ◽  
Node Metastasis ◽  
And Migration

Abstract Background Overexpression of fibroblast growth factor receptor 3 (FGFR3) has been linked to tumor progression in many types of cancer. The role of FGFR3 in melanoma remains unclear. In this study, we aimed to uncover the role of FGFR3 in the growth and metastasis of melanoma. Methods FGFR3 knockdown and overexpression strategies were employed to investigate the effects of FGFR3 on colony formation, cell apoptosis, proliferation, migration, and in vitro invasion, along with the growth and metastasis of melanoma in a xenografts mouse model. The protein expression levels of extracellular signal-regulated kinase (ERK), protein kinase B (AKT), epidermal growth factor receptor (EGFR), and epithelial-mesenchymal transition (EMT) markers were determined by Western blot analysis. Results The mRNA expression of FGFR3 was higher in melanoma tissues than normal healthy tissues. FGFR3 expression in cutaneous malignant melanoma (CMM) tissues was positively correlated with the Breslow thickness and lymph node metastasis. In A357 cells, knockdown of the FGFR3 gene decreased the colony formation ability, cell proliferation, invasion, and migration, but increased the caspase 3 activity and the apoptosis rate; overexpression of FGFR3 increased the colony formation ability, cell proliferation, invasion, and migration, but decreased the caspase 3 activity and apoptosis rates. FGFR3 knockdown also upregulated E-cadherin, downregulated N-cadherin and vimentin, and decreased the phosphorylation levels of ERK, AKT, and EGFR. In the MCC xenografts mice, knockdown of FGFR3 decreased tumor growth and metastasis. Conclusions FGFR3, which is highly expressed in CMM tissues, is correlated with increased Breslow thickness and lymph node metastasis. FGFR3 promotes melanoma growth, metastasis, and EMT behaviors, likely by affecting the phosphorylation levels of ERK, AKT, and EGFR.

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