The prognostic role of c-MYC amplification in schistosomiasis-associated colorectal cancer

Abstract Objective The purpose of this study was to explore the prognostic role of c-MYC amplification in colorectal cancer, particularly in schistosomiasis-associated colorectal cancer. Methods Three hundred and fifty four cases of colorectal cancer, which were from Qingpu Branch of Zhongshan Hospital affiliated to Fudan University, were retrospectively analyzed in a tissue microarray (TMA) format, with fluorescence in situ hybridization (FISH) assay and immunohistochemistry (IHC). Results c-MYC gene amplification was found in 14.1% (50 out of 354) of patients with colorectal cancer and was correlated with old age (P = 0.028), positive lymph node metastasis (P = 0.004) and advanced stage tumors (P = 0.002). The overexpression of c-MYC was closely associated with the amplification status (P = 0.023). Kaplan–Meier survival curves for overall survival (OS) showed a statistically significant difference for patients with c-MYC amplification in full cohort of colorectal cancer, stage III-IV set and patients with lymph node metastasis (P = 0.002, 0.034, 0.012, respectively). Further analysis found c-MYC amplification associated with poorer survival in the subgroup of colorectal cancer with schistosomiasis (CRC-S, P < 0.001), but not in colorectal cancer without schistosomiasis (CRC-NS, P = 0.155). By multivariate analysis, c-MYC amplification was an independent poor-prognostic factor in CRC-S set (P = 0.046). Conclusions Our study firstly found c-MYC amplification could predict poor prognosis in schistosomiasis-associated colorectal cancer, but not in colorectal cancer without schistosomiasis.

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Comparison of non-schistosomal colorectal cancer and schistosomal colorectal cancer

10.21203/rs.3.rs-16007/v1 ◽

2020 ◽

Author(s):

Weixia Wang ◽

Kui Lu ◽

Limei Wang ◽

Hongyan Jing ◽

Weiyu Pan ◽

...

Keyword(s):

Colorectal Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Clinical Stage ◽

Clinicopathological Features ◽

Stage Iii ◽

Prognostic Role ◽

Node Metastasis ◽

Significant Difference ◽

Cox Proportional Hazard Regression

Abstract Aim The purpose of this study was to compare clinicopathological features of patients with non-schistosomal and schistosomal colorectal cancer to explore the prognostic role of schistosoma infection in colorectal cancer(CRC). Methods 354 cases of CRC were retrospectively analyzed in a tissue microarray format. Survival curves were constructed by using the Kaplan-Meier method. Univariate and multivariate Cox proportional hazard regression models were performed to identify associations with outcome variables. Results Patients with schistosomiasis (CRC-S) were significantly older ( P <0.001) and were mostly in stage III and IV tumors ( P <0.001) than patients without schistosomiasis (CRC-NS). However, there were no significant difference between CRC-S and CRC-NS patients in other clinicopathological features. Overall, CRC-S patients were associated with adverse overall survival upon K-M analysis ( P =0.0239). By univariate and multivariate analysis, CRC-S patients were significantly correlated with OS ( P =0.041), but it was not an independent prognostic factor. In addition, age( P =0.013), gender ( P =0.008), tumor differentiation ( P =0.018) and invasive depth ( P =0.013) were all independent predictors. When patients were stratified according to clinical stage and lymph node metastasis state, the prognostic role was not consistent. In patients with stage III-IV tumors and with lymph node metastasis, schistosomiasis, gender and invasive depth were independent predictors, but not in patients with stage I-II tumors and in patients without lymph node metastasis. Conclusion Schistosomiasis is an unfavorable factor for OS and could be considered to refine risk stratification and provide better risk-oriented treatment for CRC patients with different clinical stage or lymph node metastasis state.

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The role of microvessel density, lymph node metastasis, and tumor size as prognostic factors of distant metastasis in colorectal cancer

Oncology Letters ◽

10.3892/ol.2017.5959 ◽

2017 ◽

Vol 13 (6) ◽

pp. 4327-4333 ◽

Cited By ~ 8

Author(s):

Tomonari Cho ◽

Eisuke Shiozawa ◽

Fumihiko Urushibara ◽

Nana Arai ◽

Toshitaka Funaki ◽

...

Keyword(s):

Colorectal Cancer ◽

Prognostic Factors ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Distant Metastasis ◽

Microvessel Density ◽

Tumor Size ◽

Node Metastasis

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The prognostic role of lymphovascular invasion and lymph node metastasis in perihilar and intrahepatic cholangiocarcinoma

HPB ◽

10.1016/j.hpb.2020.04.160 ◽

2020 ◽

Vol 22 ◽

pp. S264-S265

Author(s):

J. Bednarsch ◽

Z. Czigany ◽

I. Amygdalos ◽

D Morales Santana ◽

M. Den Dulk ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Intrahepatic Cholangiocarcinoma ◽

Lymphovascular Invasion ◽

Prognostic Role ◽

Node Metastasis

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Role of low dose 256-slice CT perfusion imaging in predicting mediastinal lymph node metastasis of lung cancer

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.65.6.761 ◽

2019 ◽

Vol 65 (6) ◽

pp. 761-766

Author(s):

Li Yang ◽

Lu Sun ◽

Jian Liu ◽

Qiang Liu

Keyword(s):

Lung Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Low Dose ◽

Ct Perfusion ◽

Mediastinal Lymph Node ◽

Positive Lymph Node ◽

Mediastinal Lymph Node Metastasis ◽

Node Metastasis

SUMMARY OBJECTIVE: CT perfusion (CTP) is an imaging technique that can be used to evaluate the changes in the microcirculation of tumor tissues. Our study aimed to investigate the role of CTP in predicting mediastinal lymph node metastasis. METHODS: Clinical data of 58 patients who received surgical resection of lung cancer and lymph node dissection in our hospital from June 2012 to December 2014 were collected. Patients were divided into a positive lymph node metastasis group and a negative lymph node metastasis group. Parameters of CTP, including peak enhancement intensity (PEI), perfusion value (PV), as well as blood volume (BV), were compared between the two groups. The receiver-operating characteristic (ROC) curve was used to predict mediastinal lymph node metastasis. RESULTS: The PV of the positive lymph node metastasis group was significantly higher than that of the negative group (p < 0.001). The ROC curve analysis showed that PV can be used as an index to predict mediastinal lymph node metastasis of lung cancer. The sensitivity and specificity of a PV greater than 7.5ml·min-1·ml-1 in predicting lymph node metastasis of lung cancer were 78.3 % and 91.4 %, respectively. CONCLUSION: The PV of low dose CT perfusion can be used as an index for predicting mediastinal lymph node metastasis of lung cancer.

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Role of microRNA-141 in colorectal cancer with lymph node metastasis

Experimental and Therapeutic Medicine ◽

10.3892/etm.2016.3751 ◽

2016 ◽

Vol 12 (5) ◽

pp. 3405-3410 ◽

Cited By ~ 13

Author(s):

Li Feng ◽

Hongqing Ma ◽

Liang Chang ◽

Xinliang Zhou ◽

Na Wang ◽

...

Keyword(s):

Colorectal Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Node Metastasis

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Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review

Head & Neck ◽

10.1002/hed.26541 ◽

2020 ◽

Author(s):

Orlando Guntinas‐Lichius ◽

Jovanna Thielker ◽

K. Thomas Robbins ◽

Kerry D. Olsen ◽

Ashok R. Shaha ◽

...

Keyword(s):

Systematic Review ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Prognostic Role ◽

Parotid Cancer ◽

Node Metastasis

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The prognostic role of lymphovascular invasion and lymph node metastasis in perihilar and intrahepatic cholangiocarcinoma

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2019.04.019 ◽

2019 ◽

Vol 45 (8) ◽

pp. 1468-1478 ◽

Cited By ~ 10

Author(s):

Georg Lurje ◽

Jan Bednarsch ◽

Zoltan Czigany ◽

Isabella Lurje ◽

Ivana Katharina Schlebusch ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Intrahepatic Cholangiocarcinoma ◽

Lymphovascular Invasion ◽

Prognostic Role ◽

Node Metastasis

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Mismatch repair system and p53 expression in patients with T1 and T2 colorectal cancer: Predictive role of lymph node metastasis and survival

Journal of Surgical Oncology ◽

10.1002/jso.23592 ◽

2014 ◽

Vol 109 (8) ◽

pp. 848-852 ◽

Cited By ~ 9

Author(s):

Jung Wook Huh ◽

Hee Cheol Kim ◽

Seok Hyung Kim ◽

Yoon Ah Park ◽

Yong Beom Cho ◽

...

Keyword(s):

Colorectal Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Mismatch Repair ◽

Repair System ◽

P53 Expression ◽

Node Metastasis ◽

Mismatch Repair System ◽

Predictive Role

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Expression of Hepcidin and Neogenin in colorectal cancer

Open Medicine ◽

10.1515/med-2017-0027 ◽

2017 ◽

Vol 12 (1) ◽

pp. 184-188 ◽

Cited By ~ 2

Author(s):

Pan Xiang-tao

Keyword(s):

Colorectal Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Distant Metastasis ◽

Biological Behavior ◽

Node Metastasis ◽

T Stage ◽

Significant Difference ◽

Anemia Group ◽

The Relationship

AbstractObjectiveTo investigate the expression of Hepcidin and Neogenin in tissue from patients with colorectal cancer, to evaluate the relationship between Hepcidin and Neogenin with clinical features, and to study their relationship with anemia.MethodsImmuno- histochemical method was used to detect the expression of Hepcidin and Neogenin in 62 cases of colorectal cancer. At the same time, the relationship between them and their relationship with clinical characteristics and anemia were analyzed.ResultsThe expression of Hepcidin was related to T stage (P<0.05), but not with age, gender, lymph node metastasis and distant metastasis. The expression of Neogenin was not correlated with T stage and lymph node metastasis, age, gender, and distant metastasis (P>0.05). There was no significant difference in the expression of Hepcidin and Neogenin between anemia group and non-anemia group. There was no correlation between Hepcidin and Neogenin (r =-0.04, P>0.05).ConclusionThe expression of Hepcidin in colorectal cancer was related to the T stage, and had no correlation with Neogenin. The expression of Neogenin could not be used as an objective index to reflect the biological behavior of colorectal cancer.

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Prognostic Factors in the Pulmonary Metastasectomy and Efficacy of the Repeat Pulmonary Metastasectomy from Colorectal Cancer

10.21203/rs.3.rs-60969/v1 ◽

2020 ◽

Author(s):

Masahiro Fukada ◽

Nobuhisa Matsuhashi ◽

Takao Takahashi ◽

Yoshihiro Tanaka ◽

Naoki Okumura ◽

...

Keyword(s):

Colorectal Cancer ◽

Prognostic Factors ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Risk Ratio ◽

Mediastinal Lymph Node ◽

Pulmonary Metastasectomy ◽

Mediastinal Lymph Node Metastasis ◽

Node Metastasis ◽

Significant Difference

Abstract Background Pulmonary metastasectomy from colorectal cancer (CRC) has improved with recent advances in chemotherapy, diagnostic techniques, and surgical procedures. The purpose of this study was to investigate the prognostic factors of response to pulmonary metastasectomy and the efficacy of repeat pulmonary metastasectomy.Methods This study was a retrospective, single-institution study of 126 CRC patients who underwent pulmonary metastasectomy between 2000 and 2019 at the Gifu University Hospital. Among these 126 patients, 47 cases (37.3%) had pulmonary re-recurrence after initial pulmonary metastasectomy, and 26 cases (20.6%) underwent the second pulmonary metastasectomy. ResultsThe 3- and 5- year survival rates of all 126 patients who underwent complete pulmonary metastasectomy were 84.9% and 60.8%, respectively. Univariate analysis in survival identified seven significant factors: 1) gender (p = 0.04), 2) past history of extra thoracic metastasis (p = 0.04), 3) maximum tumor size (p = 0.002), 4) hilar or mediastinal lymph node metastasis (p = 0.02), 5) preoperative carcinoembryonic antigen (CEA) level (p = 0.01), 6) preoperative carbohydrate antigen 19-9 (CA19-9) level (p = 0.03), and 7) repeat pulmonary metastasectomy for pulmonary re-recurrence (p < 0.001). On the multivariate analysis, only hilar or mediastinal lymph node metastasis (p = 0.02, risk ratio: 8.206, 95% confidence interval (CI): 1.566-34.962) and repeat pulmonary metastasectomy for pulmonary re-recurrence (p < 0.001, risk ratio: 0.054, 95% CI: 0.010-0.202) were significant. Furthermore, there was no significant difference in clinical and surgical characteristics between the initial and the second pulmonary metastasectomy except for intraoperative blood loss [10 (range 0-1130) mL vs 20 (range 0-220) mL, p = 0.008]. Conclusions Repeat pulmonary metastasectomy is likely to be safe and effective for re-recurrent cases that meet the indication. However, hilar or mediastinal lymph node metastasis was a significant independent prognostic factor of worse overall survival.

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