scholarly journals Myocardial expression profiles of candidate molecules in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia compared to those with dilated cardiomyopathy and healthy controls

Heart Rhythm ◽  
2016 ◽  
Vol 13 (3) ◽  
pp. 731-741 ◽  
Author(s):  
Deniz Akdis ◽  
Argelia Medeiros-Domingo ◽  
Anna Gaertner-Rommel ◽  
Jeannette I. Kast ◽  
Frank Enseleit ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Dilated Cardiomyopathy ◽  
Expression Profiles ◽  
Arrhythmogenic Right Ventricular Cardiomyopathy ◽  
Healthy Controls ◽  
Ventricular Cardiomyopathy

Heart muscle diseases

2012 ◽  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Right Ventricular ◽  
Dilated Cardiomyopathy ◽  
Fabry Disease ◽  
Heart Muscle ◽  
Cardiac Amyloidosis ◽  
Arrhythmogenic Right Ventricular Cardiomyopathy ◽  
Restrictive Cardiomyopathy ◽  
Left Ventricular ◽  
Ventricular Cardiomyopathy

Classification 418Dilated cardiomyopathy 420Dilated cardiomyopathy: treatment 422Hypertrophic cardiomyopathy 424Hypertrophic cardiomyopathy: investigations 428Hypertrophic cardiomyopathy: treatment 430Restrictive cardiomyopathy 432Cardiac amyloidosis 434Cardiac amyloidosis: treatment 436Fabry disease 438Arrhythmogenic right ventricular cardiomyopathy (ARVC) 440ARVC: management 442Left ventricular non-compaction ...

scholarly journals Circulating miR-185-5p as a Potential Biomarker for Arrhythmogenic Right Ventricular Cardiomyopathy

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2578
Author(s):  
Claudia Sacchetto ◽  
Zenab Mohseni ◽  
Robin M. W. Colpaert ◽  
Libero Vitiello ◽  
Marzia De Bortoli ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Arrhythmogenic Right Ventricular Cardiomyopathy ◽  
Disease Onset ◽  
Area Under The Curve ◽  
P Value ◽  
Healthy Controls ◽  
Ventricular Cardiomyopathy ◽  
Characteristic Analysis ◽  
Potential Biomarker ◽  
Fatty Replacement

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic cardiac disease characterized by progressive myocardial fibro-fatty replacement, arrhythmias and risk of sudden death. Its diagnosis is challenging and often it is achieved after disease onset or postmortem. In this study, we sought to identify circulating microRNAs (miRNAs) differentially expressed in ARVC patients compared to healthy controls. In the pilot study, we screened the expression of 754 miRNAs from 21 ARVC patients and 20 healthy controls. After filtering the miRNAs considering a log fold-change cut-off of ±1, p-value < 0.05, we selected five candidate miRNAs for a subsequent validation study in which we used TaqMan-based real-time PCR to analyse samples from 37 ARVC patients and 30 healthy controls. We found miR-185-5p significantly upregulated in ARVC patients. Receiver operating characteristic analysis indicated an area under the curve of 0.854, corroborating the link of this miRNA and ARVC pathophysiology.

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