Genetic and non-genetic factors affecting the visual outcome of ocular Behcet’s disease

BackgroundThe neuro-ophthalmological manifestations of Behcet’s disease (BD) are rare, and data regarding their characteristics and outcome are lacking.ObjectiveTo report prevalence, main characteristics and outcome of neuro-ophthalmological manifestations in BD.Patients and methodsThis is a retrospective monocentric study of 217 patients diagnosed with neuro-Behçet’s disease (NBD), of whom 29 (13.3%) patients presented with neuro-ophthalmological manifestations (55% of men and mean±SD age of 26±8 years). All patients underwent a detailed ophthalmological examination and were followed up in the internal medicine and the ophthalmology departments.ResultsNeuro-ophthalmological manifestations were the first presentation of BD in 45% of patients and developed later in the course of the disease in 55% of patients. They are divided into parenchymal (PM) and non-parenchymal (NPM)-related manifestations in, respectively, 13 patients (45%) and 16 patients (55%). PM included papillitis in seven patients (53.8%), retrobulbar optic neuritis in four patients (30.8%) and third cranial nerve palsy in two patients (15.4%). NPM included papilloedema related to cerebral venous thrombosis in all 16 patients, of whom 6 patients (37.5%) had sixth cranial nerve palsy. At initial examination, 93.1% of patients had visual alterations, including mainly decreased visual acuity visual field defects and/or diplopia. All patients were treated with corticosteroids and 79% of patients received immunosuppressive agents. After treatment, the visual outcome improved or stabilised in 66.7% of patients while it worsened in 33.3. The mean±SD logarithm of the minimum angle of resolution visual acuity improved from 0.4±0.3 at diagnosis to 0.2±0.3 after therapy. 10.3% and 3.4% of patients were legally blind at diagnosis and after therapy, respectively.ConclusionNeuro-ophthalmological manifestations of BD represented 13% of NBD. They could be potentially severe and disabling. Prompt treatment is the key factor in improving visual outcome.

Download Full-text

Neutrophil adhesion to endothelial cells and factors affecting adhesion in patients with Behcet's disease.

Annals of the Rheumatic Diseases ◽

10.1136/ard.55.2.128 ◽

1996 ◽

Vol 55 (2) ◽

pp. 128-133 ◽

Cited By ~ 64

Author(s):

S Sahin ◽

T Akoglu ◽

H Direskeneli ◽

L S Sen ◽

R Lawrence

Keyword(s):

Endothelial Cells ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Neutrophil Adhesion ◽

Factors Affecting ◽

Behcet's Disease

Download Full-text

Ethiopathogenesis of Behçet's Disease

Güncel Retina Dergisi (Current Retina Journal) ◽

10.37783/crj-0113 ◽

2018 ◽

pp. 324-328

Keyword(s):

Behçet’S Disease ◽

Genetic Factors ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Skin Lesions ◽

Th2 Cells ◽

Innate And Adaptive Immunity ◽

Behcet's Disease ◽

Oral Ulcers ◽

Th 1

Behçet’s disease (BD) is a chronic multisystem inflammatory disease characterized mainly by recurrent oral ulcers, ocular inflammation, genital ulcers, and skin lesions, presenting with remission and exacerbations. The pathogenesis of BD has not been fully elucidated since it has a broad spectrum of phenotypic heterogeneity and complex immunopathogenesis. BD has been considered that both environmental and genetic factors contribute to its onset and development. Recent advances in molecular biology and genetics show us that particular genes encompass both innate and adaptive immunity, and confirm the importance of the predominant polarization towards helper T cell (Th)1 versus Th2 cells, and the involvement of Th17 cells in BD.

Download Full-text

Using hierarchical similarity to examine the genetics of Behçet’s disease

BMC Research Notes ◽

10.1186/s13104-021-05767-6 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Samuel J. Shenoi ◽

Erich J. Baker

Keyword(s):

Autoimmune Diseases ◽

Behçet’S Disease ◽

Inflammatory Disease ◽

Genetic Factors ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Genetic Interactions ◽

Behcet's Disease ◽

Genetic Overlap ◽

Historic Silk

Abstract Objective Behçet’s disease (BD) is a multisystem inflammatory disease that affects patients along the historic silk road. Thus far, the pathogenesis of the disease has proved elusive due to the complex genetic interactions of the disease. In this paper, we seek to clarify the genetic factors of the disease while also uncovering other diseases of interest that present with a similar genotype as BD. Results To do this, we employ a convergent functional genomics approach by leveraging the hierarchical similarity tool available in Geneweaver. Through our analysis, we were able to ascertain 7 BD consensus genes and 16 autoimmune diseases with genetic overlap with BD. The results of our study will inform further research into the pathogenesis of Behçet’s disease.

Download Full-text

C 48 Visual outcome in Behçet's disease

La Revue de Médecine Interne ◽

10.1016/s0248-8663(05)82295-7 ◽

1993 ◽

Vol 14 ◽

pp. 47s

Author(s):

KF. Tabbara ◽

PS. Chavis ◽

S. Al Balla ◽

AK. Al-Momen

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Visual Outcome ◽

Behcet's Disease

Download Full-text

The natural course and factors affecting severity of Behçet’s disease: a single-center cohort of 368 patients

Rheumatology International ◽

10.1007/s00296-015-3310-5 ◽

2015 ◽

Vol 35 (12) ◽

pp. 2103-2107 ◽

Cited By ~ 14

Author(s):

Nilay Ugurlu ◽

Selen Bozkurt ◽

Ali Bacanli ◽

Ayse Akman-Karakas ◽

Soner Uzun ◽

...

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Natural Course ◽

Single Center ◽

Factors Affecting ◽

Behcet's Disease

Download Full-text

Immunosuppression in Behçet's disease Clinical management and long-term visual outcome

Ocular Immunology and Inflammation ◽

10.3109/09273949509085037 ◽

1995 ◽

Vol 3 (2) ◽

pp. 99-106 ◽

Cited By ~ 1

Author(s):

J. Palmares ◽

J. Castro-correia ◽

M. F. Coutinho ◽

D. Araújo ◽

L. Delgado

Keyword(s):

Behçet’S Disease ◽

Clinical Management ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Visual Outcome ◽

Behcet's Disease

Download Full-text

Uveitis in juvenile Behçet's disease: clinical course and visual outcome compared with adult patients

Eye ◽

10.1038/eye.2008.397 ◽

2009 ◽

Vol 23 (11) ◽

pp. 2034-2041 ◽

Cited By ~ 6

Author(s):

M Kramer ◽

R Amer ◽

M Mukamel ◽

M Snir ◽

T Jaouni ◽

...

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Clinical Course ◽

Behçet's Disease ◽

Visual Outcome ◽

Adult Patients ◽

Behcet's Disease

Download Full-text

Proinflammatory Cytokines and C-Reactive Protein in Uveitis Associated with Behçet’s Disease

Mediators of Inflammation ◽

10.1155/2014/396204 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 17

Author(s):

Marina Mesquida ◽

Blanca Molins ◽

Victor Llorenç ◽

Maite Sainz de la Maza ◽

María Victoria Hernandez ◽

...

Keyword(s):

Disease Activity ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Visual Outcome ◽

Inactive Disease ◽

C Reactive Protein ◽

Behcet's Disease ◽

Reactive Protein ◽

Cytokine Profiles

The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behçet’s disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concentration of interferon-γ(IFN-γ), interleukin-1β(IL-1β), IL-12p70, IL-17A, tumor necrosis factor-α(TNF-α), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls. In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive. Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome. Levels of IFN-γand TNF-αwere significantly increased in patients with active uveitis associated to BD compared to controls (P<0.05). IFN-γ, TNF-α, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P<0.05). Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P<0.05). No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications. In summary, increased serum levels of IFN-γ, TNF-α, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity.

Download Full-text