scholarly journals Proinflammatory Cytokines and C-Reactive Protein in Uveitis Associated with Behçet’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Marina Mesquida ◽  
Blanca Molins ◽  
Victor Llorenç ◽  
Maite Sainz de la Maza ◽  
María Victoria Hernandez ◽  
...  
Keyword(s):  
Disease Activity ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Visual Outcome ◽  
Inactive Disease ◽  
C Reactive Protein ◽  
Behcet's Disease ◽  
Reactive Protein ◽  
Cytokine Profiles

The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behçet’s disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concentration of interferon-γ(IFN-γ), interleukin-1β(IL-1β), IL-12p70, IL-17A, tumor necrosis factor-α(TNF-α), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls. In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive. Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome. Levels of IFN-γand TNF-αwere significantly increased in patients with active uveitis associated to BD compared to controls (P<0.05). IFN-γ, TNF-α, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P<0.05). Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P<0.05). No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications. In summary, increased serum levels of IFN-γ, TNF-α, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity.

scholarly journals Title: Predictive value of Erythrocyte Sedimentation Rate and C-Reactive Protein in Behcet's Disease Activity and Manifestations: A Cross-Sectional Study

2021 ◽  
Author(s):  
Amirhossein Parsaei ◽  
Soroush Moradi ◽  
Maryam Masoumi ◽  
Fereydoun Davatchi ◽  
Anahita Najafi ◽  
...  
Keyword(s):  
Disease Activity ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Predictive Value ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
C Reactive Protein ◽  
Behcet's Disease ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation

Abstract Background: Behcet’s disease (BD) as a chronic inflammatory condition that affects the eyes, skin, central nervous system, gastrointestinal tract and vessels. According to the literature, the exact value of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in predicting active manifestations of BD remains controversial. In this study, we aim to assess and compare values of ESR and CRP between BD patients with active/ inactive BD and active/inactive manifestations of the disease. Moreover, we try to determine the predictive value of ESR and CRP for disease activity.Methods: Participants (n=514) were drug-naïve BD patients; Based on last two visits, ESR and CRP values, disease activity, and active manifestations were recorded. The Man-Whitney U test measured the associations, and the binomial logistic regression evaluated the predictive value of ESR and CRP for active disease and each active manifestation. The sensitivity and specificity and the area under the curve (AUC) for each model were determined using receiver operating characteristic curves (ROC). Multiple regressions were run to predict BD activity score from ESR and CRP.Result: Patients with active ocular, oral, genital, joint and dermal manifestations had higher ESR and CRP values (Mann-Whitney U test, p< 0.05 for all). Binomial logistic regressions showed that ESR had valuable predictive value for active BD (OR =1.09[1.04-1.13] , AUC = 0.79[0.74-0.83], p<0.001) and active vascular manifestations (1.03[1.01-1.05], AUC = 0.85[0.79-0.92], p<0.001). CRP had good predictive value for active vascular manifestations (OR 1.98[1.45-2.72], AUC = 0.86[0.8-0.91], p<0.001,). The optimal value of ESR ≥ 10.5 and ESR ≥ 42.5 could predict active BD and active vascular manifestations with Sensitivity,Specificity = 71%,75% and =81%, 83% respectively.Conclusions: ESR and CRP are both associated with active BD and most manifestations of the diseases. They can be used for the prediction of active BD and active vascular manifestations in BD patients. Further studies can help to confirm the findings of the current research.

scholarly journals Homocysteine May Involve in the Pathogenesis of Behcet's Disease by Inducing Inflammation

2008 ◽  
Vol 2008 ◽  
pp. 1-9 ◽  
Author(s):  
Selda Pelin Kartal Durmazlar ◽  
Ahmet Akgul ◽  
Fatma Eskioglu
Keyword(s):  
Behçet’S Disease ◽  
Tumor Necrosis ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Clinical Manifestations ◽  
Healthy Individuals ◽  
C Reactive Protein ◽  
Behcet's Disease ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation

Objective. Our aim was to evaluate the significance of homocysteine (Hcy) in Behcet's disease (BD) and the association of elevated Hcy levels associated with the indices of inflammation in BD.Methods. Untreated 70 patients with BD and 33 healthy individuals were included into the study. Hcy, tumor necrosis alpha (TNF-), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were evaluated with respect to activity and specific individual clinical manifestations of the disease.Results. Hcy levels were found significantly elevated in active BD when compared to inactive BD and healthy controls. Hcy levels were found to have high correlation with the number of active clinical manifestations increased. A significant positive correlation was found between serum Hcy and TNF- levels, CRP, and ESR. Hcy was found to be the best predictor of TNF- among other parameters.Conclusion. Hcy may involve in the pathogenesis of BD by inducing inflammation.

scholarly journals Predictive value of erythrocyte sedimentation rate and C-reactive protein in Behcet's disease activity and manifestations: a cross-sectional study

2021 ◽  
Author(s):  
Amirhossein Parsaei ◽  
Soroush Moradi ◽  
Maryam Masoumi ◽  
Fereydoun Davatchi ◽  
Anahita Najafi ◽  
...  
Keyword(s):  
Disease Activity ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Predictive Value ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
C Reactive Protein ◽  
Behcet's Disease ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation

Abstract Background Behcet’s disease (BD) as a chronic inflammatory condition that affects the eyes, skin, central nervous system, gastrointestinal tract and vessels. According to the literature, the exact value of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in predicting active manifestations of BD remains controversial. In this study, we aim to assess and compare values of ESR and CRP between BD patients with active/ inactive BD and active/inactive manifestations of the disease. Moreover, we try to determine the predictive value of ESR and CRP for disease activity. Methods Participants (n = 514) were drug-naïve BD patients; Based on last two visits, ESR and CRP values, disease activity, and active manifestations were recorded. The Man-Whitney U test measured the associations, and the binomial logistic regression evaluated the predictive value of ESR and CRP for active disease and each active manifestation. The sensitivity and specificity and the area under the curve (AUC) for each model were determined using receiver operating characteristic curves (ROC). Multiple regressions were run to predict BD activity score from ESR and CRP. Result Patients with active ocular, oral, genital, joint and dermal manifestations had higher ESR and CRP values (Mann-Whitney U test, p < 0.05 for all). Binomial logistic regressions showed that ESR had valuable predictive value for active BD (OR = 1.09[1.04–1.13], AUC = 0.79[0.74–0.83], p < 0.001) and active vascular manifestations (1.03[1.01–1.05], AUC = 0.85[0.79–0.92], p < 0.001). CRP had good predictive value for active vascular manifestations (OR 1.98[1.45–2.72], AUC = 0.86[0.8–0.91], p < 0.001,). The optimal value of ESR ≥ 10.5 and ESR ≥ 42.5 could predict active BD and active vascular manifestations with Sensitivity,Specificity = 71%,75% and = 81%, 83% respectively. Conclusions ESR and CRP are both associated with active BD and most manifestations of the diseases. They can be used for the prediction of active BD and active vascular manifestations in BD patients. Further studies can help to confirm the findings of the current research.

Sign in / Sign up

Export Citation Format

Share Document