Behçet's disease ocular attack score 24 and visual outcome in patients with Behçet's disease

Abstract Purpose To determine the application of fluorescein angiographic (FA) findings and Behcet’s disease ocular attack score 24 (BOS24) scoring system in predicting poor visual outcome in patients with ocular Behcet’s disease. Study design Retrospective cohort study. Methods We included 73 eyes of 38 patients with ocular Behcet’s disease who underwent FA and reviewed FA images, anterior chamber cells, vitreous opacity, retinal and optic disc lesions, which are parameters in BOS24. The correlation between FA findings, BOS24, and visual acuity was assessed. Results Optic disc hyperfluoresence (74%), diffuse posterior pole leakage (52%) and diffuse peripheral leakage (52%) were the three most common findings. Common complications were peripheral capillary nonperfusion (29%), arterial narrowing (22%), and macular ischemia (19%). BOS24 scores of ≥ 6 (p < 0.0001), arterial narrowing (p < 0.0001), and severe posterior pole leakage (p = 0.004) were significantly associated with poor visual outcome. Combining significant FA findings: arterial narrowing and severe posterior pole leakage, to BOS24 ≥ 6 results in an increased relative risk of developing poor visual acuity from 7.30 to 10.43 and 1.89 to 2.02 respectively. Conclusion Fluorescein angiography is an important investigation for predicting poor visual outcome. BOS24 may be a useful alternative when fluorescein angiographic is unavailable.

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Neuro-ophthalmological manifestations of Behçet’s disease

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2017-311334 ◽

2018 ◽

Vol 103 (1) ◽

pp. 83-87 ◽

Cited By ~ 2

Author(s):

Ammr Alghamdi ◽

Bahram Bodaghi ◽

Chloé Comarmond ◽

Anne Claire Desbois ◽

Fanny Domont ◽

...

Keyword(s):

Visual Acuity ◽

Behçet’S Disease ◽

Cranial Nerve ◽

Cranial Nerve Palsy ◽

Nerve Palsy ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Visual Outcome ◽

Ophthalmological Examination ◽

Behcet's Disease

BackgroundThe neuro-ophthalmological manifestations of Behcet’s disease (BD) are rare, and data regarding their characteristics and outcome are lacking.ObjectiveTo report prevalence, main characteristics and outcome of neuro-ophthalmological manifestations in BD.Patients and methodsThis is a retrospective monocentric study of 217 patients diagnosed with neuro-Behçet’s disease (NBD), of whom 29 (13.3%) patients presented with neuro-ophthalmological manifestations (55% of men and mean±SD age of 26±8 years). All patients underwent a detailed ophthalmological examination and were followed up in the internal medicine and the ophthalmology departments.ResultsNeuro-ophthalmological manifestations were the first presentation of BD in 45% of patients and developed later in the course of the disease in 55% of patients. They are divided into parenchymal (PM) and non-parenchymal (NPM)-related manifestations in, respectively, 13 patients (45%) and 16 patients (55%). PM included papillitis in seven patients (53.8%), retrobulbar optic neuritis in four patients (30.8%) and third cranial nerve palsy in two patients (15.4%). NPM included papilloedema related to cerebral venous thrombosis in all 16 patients, of whom 6 patients (37.5%) had sixth cranial nerve palsy. At initial examination, 93.1% of patients had visual alterations, including mainly decreased visual acuity visual field defects and/or diplopia. All patients were treated with corticosteroids and 79% of patients received immunosuppressive agents. After treatment, the visual outcome improved or stabilised in 66.7% of patients while it worsened in 33.3. The mean±SD logarithm of the minimum angle of resolution visual acuity improved from 0.4±0.3 at diagnosis to 0.2±0.3 after therapy. 10.3% and 3.4% of patients were legally blind at diagnosis and after therapy, respectively.ConclusionNeuro-ophthalmological manifestations of BD represented 13% of NBD. They could be potentially severe and disabling. Prompt treatment is the key factor in improving visual outcome.

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C 48 Visual outcome in Behçet's disease

La Revue de Médecine Interne ◽

10.1016/s0248-8663(05)82295-7 ◽

1993 ◽

Vol 14 ◽

pp. 47s

Author(s):

KF. Tabbara ◽

PS. Chavis ◽

S. Al Balla ◽

AK. Al-Momen

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Visual Outcome ◽

Behcet's Disease

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Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack

Modern Rheumatology ◽

10.3109/s10165-008-0064-x ◽

2008 ◽

Vol 18 (4) ◽

pp. 354-358 ◽

Cited By ~ 25

Author(s):

Yuki Nanke ◽

Shigeru Kotake ◽

Mari Goto ◽

Hiroshi Ujihara ◽

Masao Matsubara ◽

...

Keyword(s):

T Cells ◽

Regulatory T Cells ◽

Behçet’S Disease ◽

Peripheral Blood ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Predictive Marker ◽

Behcet's Disease ◽

Ocular Attack

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Immunosuppression in Behçet's disease Clinical management and long-term visual outcome

Ocular Immunology and Inflammation ◽

10.3109/09273949509085037 ◽

1995 ◽

Vol 3 (2) ◽

pp. 99-106 ◽

Cited By ~ 1

Author(s):

J. Palmares ◽

J. Castro-correia ◽

M. F. Coutinho ◽

D. Araújo ◽

L. Delgado

Keyword(s):

Behçet’S Disease ◽

Clinical Management ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Visual Outcome ◽

Behcet's Disease

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Uveitis in juvenile Behçet's disease: clinical course and visual outcome compared with adult patients

Eye ◽

10.1038/eye.2008.397 ◽

2009 ◽

Vol 23 (11) ◽

pp. 2034-2041 ◽

Cited By ~ 6

Author(s):

M Kramer ◽

R Amer ◽

M Mukamel ◽

M Snir ◽

T Jaouni ◽

...

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Clinical Course ◽

Behçet's Disease ◽

Visual Outcome ◽

Adult Patients ◽

Behcet's Disease

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Behçet’s disease ocular attack score 24: evaluation of ocular disease activity before and after initiation of infliximab

Japanese Journal of Ophthalmology ◽

10.1007/s10384-013-0294-0 ◽

2014 ◽

Vol 58 (2) ◽

pp. 120-130 ◽

Cited By ~ 33

Author(s):

Toshikatsu Kaburaki ◽

◽

Kenichi Namba ◽

Koh-hei Sonoda ◽

Takeshi Kezuka ◽

...

Keyword(s):

Disease Activity ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Ocular Disease ◽

Behcet's Disease ◽

Ocular Attack ◽

Before And After

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Proinflammatory Cytokines and C-Reactive Protein in Uveitis Associated with Behçet’s Disease

Mediators of Inflammation ◽

10.1155/2014/396204 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 17

Author(s):

Marina Mesquida ◽

Blanca Molins ◽

Victor Llorenç ◽

Maite Sainz de la Maza ◽

María Victoria Hernandez ◽

...

Keyword(s):

Disease Activity ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Visual Outcome ◽

Inactive Disease ◽

C Reactive Protein ◽

Behcet's Disease ◽

Reactive Protein ◽

Cytokine Profiles

The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behçet’s disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concentration of interferon-γ(IFN-γ), interleukin-1β(IL-1β), IL-12p70, IL-17A, tumor necrosis factor-α(TNF-α), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls. In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive. Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome. Levels of IFN-γand TNF-αwere significantly increased in patients with active uveitis associated to BD compared to controls (P<0.05). IFN-γ, TNF-α, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P<0.05). Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P<0.05). No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications. In summary, increased serum levels of IFN-γ, TNF-α, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity.

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