A rare MSH2 mutation causes defective binding to hMSH6, normal hMSH2 staining, and loss of hMSH6 at advanced cancer stage

2014 ◽  
Vol 45 (10) ◽  
pp. 2162-2167 ◽  
Author(s):  
Daria Carmela Loconte ◽  
Margherita Patruno ◽  
Patrizia Lastella ◽  
Carmela Di Gregorio ◽  
Valentina Grossi ◽  
...  
Keyword(s):  
Advanced Cancer ◽  
Cancer Stage ◽  
Msh2 Mutation ◽  
Advanced Cancer Stage

Zaawansowany proces nowotworowy u chłopca z pierwotnym guzem germinalnym jądra – opis przypadku

2019 ◽  
Vol 23 (2) ◽  
Author(s):  
Milena Król ◽  
Jagoda Dolecka ◽  
Julia Zatońska ◽  
Michał Romiszewski ◽  
Katarzyna Pawelec
Keyword(s):  
Germ Cell ◽  
Advanced Cancer ◽  
Germ Cell Tumors ◽  
Young Patients ◽  
Cell Tumor ◽  
Occurrence Rate ◽  
Cancer Stage ◽  
Vision Disorder ◽  
Specific Symptoms ◽  
Advanced Cancer Stage

Testicular cancers (germ cell tumors) are rarely diagnosed in patients below eighteen years old. The low occurrence rate may decrease the alertness of the physicians. In consequence, the cancer is detected late and most young patients are referred to oncological wards with an advanced cancer stage. The article describes the case of a young patient who looked for medical consultation due to non-specific symptoms like: diarrhea, weakness and vision disorder. Diagnostic tests revealed the germ cell tumor with metastasis to liver, lungs and brain. The diagnosis was established in an advanced cancer stage, which severely reduced the chance of a successful treatment and put the patient life at risk. The case is being reviewed to increase the awareness of the testicular cancer amongst physicians of all specialties because the illness can be treated effectively if it is diagnosed very early.

scholarly journals Low Educational Level is Associated with Advanced Cancer Stage in Brazil.

2015 ◽  
Vol 44 (suppl_1) ◽  
pp. i3-i4
Author(s):  
K. Ribeiro ◽  
J. Eluf Neto ◽  
C. Luizaga ◽  
V. Lombardo ◽  
V. Leite
Keyword(s):  
Advanced Cancer ◽  
Educational Level ◽  
Cancer Stage ◽  
Advanced Cancer Stage

Mo1165 Black Patients With Colorectal Cancer Have More Advanced Cancer Stage at Time of Diagnosis Among a Large, Urban, Underserved Safety-Net Population

2016 ◽  
Vol 150 (4) ◽  
pp. S656
Author(s):  
Chuck Chan ◽  
Gabriella Bartos ◽  
Harleen Dyal ◽  
Taft Bhuket ◽  
Benny Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Advanced Cancer ◽  
Safety Net ◽  
Cancer Stage ◽  
Black Patients ◽  
Advanced Cancer Stage

scholarly journals T1721 Activin Type II Receptor (ACVR2) Expression Predicts Adenoma and Primary Cancer Size and Advanced Cancer Stage

2010 ◽  
Vol 138 (5) ◽  
pp. S-564-S-565
Author(s):  
Sun-Young Lee ◽  
Judith C. Sporn ◽  
John M. Carethers ◽  
Dae-Yong Hwang ◽  
Moo-Kyung Seong ◽  
...  
Keyword(s):  
Advanced Cancer ◽  
Cancer Stage ◽  
Type Ii ◽  
Primary Cancer ◽  
Advanced Cancer Stage

Frequency, predictors, and outcomes of urine drug test among patients with advanced cancer on chronic opioid therapy at an outpatient supportive care clinic.

2016 ◽  
Vol 34 (26_suppl) ◽  
pp. 94-94
Author(s):  
Joseph Anthony Arthur ◽  
Tonya Edwards ◽  
David Hui ◽  
Jessica Marie Waletich-Flemming ◽  
Suresh K. Reddy ◽  
...  
Keyword(s):  
Supportive Care ◽  
Cancer Patients ◽  
Advanced Cancer ◽  
Opioid Therapy ◽  
Cancer Stage ◽  
Chronic Opioid Therapy ◽  
Advanced Cancer Patients ◽  
Care Clinic ◽  
Urine Drug ◽  
Outpatient Supportive Care

94 Background: Data on the utilization and outcomes of urine drug tests (UDT) among advanced cancer patients is limited. The main objective of this study was to determine the factors associated with UDT ordering and results in advanced cancer outpatients. Methods: A retrospective chart review of 1058 patients seen from March 2014 to November 2015 at an outpatient supportive care clinic was conducted. Sixty-one patients on chronic opioid therapy who underwent UDT were identified. A control group of 120 patients who did not undergo UDT was selected for comparison of information on demographic and clinical characteristics. Results: 61/1058 patients (6%) underwent UDT. 33/61 patients (54%) had abnormal results. Multivariate analysis found that the odds ratio for UDT ordering was 3.9 in CAGE positive patients (p = 0.002), 4.41 in patients less than 45years (p < 0.001), 5.58 in patients with moderate to severe pain (ESAS pain score ≥ 4) (p < 0.001), 0.27 in patients with advanced cancer stage, (p = 0.008), and 0.25 in patients with moderate to severe fatigue (p = 0.001). Among 52 abnormal UDT results in 33 patients, the most common opioid findings were: prescribed opioids absent in urine (14/52, 27%) and un-prescribed opioids in urine (13/52, 25%). Conclusions: UDT was used infrequently among advanced cancer patients receiving outpatient chronic opioid therapy. Younger age, CAGE positivity, early cancer stage or NED status, higher pain intensity, and lower fatigue were significant predictors of UDT ordering. More than 50% of UDTs were abnormal. More research is necessary to better characterize aberrant opioid use in advanced cancer patients.

Illness understanding of oncology patients in a community-based cancer institute.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e21605-e21605
Author(s):  
Shanthi Sivendran ◽  
Sarah Jenkins ◽  
Sarah Svetec ◽  
Michael Horst ◽  
Kristina Braine Newport ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Advanced Cancer ◽  
Stage I ◽  
Cancer Stage ◽  
Stage At Diagnosis ◽  
Advanced Cancer Patients ◽  
Community Based ◽  
Oncology Patients ◽  
Remission Status ◽  
Number Of Patients

e21605 Background: Several studies have demonstrated patients have a poor understanding of prognosis, survival and effectiveness of chemotherapy, particularly in the setting of advanced cancer. This study examines oncology patients’ understanding of their illness based on accurate reporting of stage at diagnosis as well as knowledge of remission status. Methods: 208 cancer patients previously treated at our large community based cancer institute participated in The Consumer-Based Cancer Care Value Index (CCCVI) Field Survey. Electronic medical record (EMR) documentation of stage at diagnosis and remission status were compared to patients’ self-reported responses. Concordance of responses and variables influencing discordance were evaluated. Results: 51.0% of patients’ self-reported cancer stage matched the abstracted stage with the highest concordance in the advanced cancer patients (72%) versus stage I-III patients (36.4%-61.5%). Unexpectedly, discordance was lower among advanced cancer patients as compared to stage I-III patients (p = 0.0528) Those who were concordant for cancer stage at diagnosis were significantly more likely to be female (p = 0.001), under the age of 65 (p = 0.01), have an income greater than $60,000 (p = 0.03), and have more education (p = 0.02). 64.4% of patients’ self-reported remission status matched the abstracted status. Nearly 30% of patients were not sure about their status even when they were in remission. Conclusions: Our findings confirm that more than one quarter of patients with advanced cancer have poor illness understanding, as well as highlights that an even greater number of patients with early stage I-III cancers have poor illness understanding. These observations highlight the need to improve illness understanding for patients across the entire cancer continuum.

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