scholarly journals Visual deprivation induces transient upregulation of oligodendrocyte progenitor cells in the subcortical white matter of mouse visual cortex

2021 ◽  
Author(s):  
Hyeryun Shin ◽  
Hideki Derek Kawai
Keyword(s):  
Visual Cortex ◽  
White Matter ◽  
Progenitor Cells ◽  
Subcortical White Matter ◽  
Visual Deprivation ◽  
Oligodendrocyte Progenitor Cells ◽  
Oligodendrocyte Progenitor ◽  
Mouse Visual Cortex

scholarly journals Identification, Isolation, and Promoter-Defined Separation of Mitotic Oligodendrocyte Progenitor Cells from the Adult Human Subcortical White Matter

1999 ◽  
Vol 19 (22) ◽  
pp. 9986-9995 ◽  
Author(s):  
Neeta Singh Roy ◽  
Su Wang ◽  
Catherine Harrison-Restelli ◽  
Abdellatif Benraiss ◽  
Richard A. R. Fraser ◽  
...  
Keyword(s):  
White Matter ◽  
Progenitor Cells ◽  
Subcortical White Matter ◽  
Oligodendrocyte Progenitor Cells ◽  
Oligodendrocyte Progenitor ◽  
Adult Human

scholarly journals Sensitive timing of undifferentiation in oligodendrocyte progenitor cells and their enhanced maturation in primary visual cortex of binocularly enucleated mice

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257395
Author(s):  
Hyeryun Shin ◽  
Hideki Derek Kawai
Keyword(s):  
Visual Cortex ◽  
Progenitor Cells ◽  
Primary Visual Cortex ◽  
Early Period ◽  
Bottom Layer ◽  
Sensitive Period ◽  
Oligodendrocyte Progenitor Cells ◽  
Shh Signaling ◽  
Oligodendrocyte Progenitor

Sensory experience modulates proliferation, differentiation, and migration of oligodendrocyte progenitor cells (OPCs). In the mouse primary visual cortex (V1), visual deprivation-dependent modulation of OPCs has not been demonstrated. Here, we demonstrate that undifferentiated OPCs developmentally peaked around postnatal day (P) 25, and binocular enucleation (BE) from the time of eye opening (P14-15) elevated symmetrically-divided undifferentiated OPCs in a reversible G0/G1 state even more at the bottom lamina of the cortex by reducing maturing oligodendrocyte (OL) lineage cells. Experiments using the sonic hedgehog (Shh) signaling inhibitor cyclopamine in vivo suggested that Shh signaling pathway was involved in the BE-induced undifferentiation process. The undifferentiated OPCs then differentiated within 5 days, independent of the experience, becoming mostly quiescent cells in control mice, while altering the mode of sister cell symmetry and forming quiescent as well as maturing cells in the enucleated mice. At P50, BE increased mature OLs via symmetric and asymmetric modes of cell segregation, resulting in more populated mature OLs at the bottom layer of the cortex. These data suggest that fourth postnatal week, corresponding to the early critical period of ocular dominance plasticity, is a developmentally sensitive period for OPC state changes. Overall, the visual loss promoted undifferentiation at the early period, but later increased the formation of mature OLs via a change in the mode of cell type symmetry at the bottom layer of mouse V1.

scholarly journals Early Proliferation Does Not Prevent the Loss of Oligodendrocyte Progenitor Cells during the Chronic Phase of Secondary Degeneration in a CNS White Matter Tract

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65710 ◽  
Author(s):  
Sophie C. Payne ◽  
Carole A. Bartlett ◽  
Donna L. Savigni ◽  
Alan R. Harvey ◽  
Sarah A. Dunlop ◽  
...  
Keyword(s):  
White Matter ◽  
Progenitor Cells ◽  
Chronic Phase ◽  
Oligodendrocyte Progenitor Cells ◽  
White Matter Tract ◽  
Secondary Degeneration ◽  
Oligodendrocyte Progenitor

scholarly journals Intranasal delivery of human oligodendrocyte precursor cells enhances regenerative effects in premature rat brain following hypoxic–ischemic injury

2021 ◽  
Author(s):  
Jing Zang ◽  
Yinxiang Yang ◽  
Qian Guan ◽  
Xiaohua Wang ◽  
Xin Zhong ◽  
...  
Keyword(s):  
White Matter ◽  
Progenitor Cells ◽  
Premature Infants ◽  
Myelin Sheath ◽  
White Matter Injury ◽  
Therapeutic Effects ◽  
Oligodendrocyte Progenitor Cells ◽  
Intranasal Delivery ◽  
Oligodendrocyte Progenitor ◽  
Hypoxia Ischemia

Abstract Background White matter injury is a common ischemic brain injury in premature infants and for which there is no effective treatment. Stem cell transplantation has emerged as a novel approach for replacing damaged brain tissues and promoting regenerative processes. Since intracerebral transplantation is not clinically feasible for premature infants, intranasal delivery of cells to the brain is a promising, noninvasive therapeutic approach for restoring the damaged brain. This study was conducted to investigate whether transplanted human oligodendrocyte progenitor cells exhibit neuroprotective effects in a rat model of WMI in premature infants. Methods SD rats aged 3 days were randomly divided into sham group, preterm white matter injury group and nasal transplantation group. Hypoxia–ischemia was induced in 3-day-old rat pups by right carotid artery ligation, followed by exposure to 6% oxygen for 90 min. Rats were intranasally administered the cell suspension (250,000 cells in 6 µL) twice in each nostril (1 × 106 cells total), and myelin basic protein immunofluorescence staining and transmission electron microscopy were performed to assess endogenous myelin growth in the right hemispheres. Behavioral tests, including the Morris water maze, adhesive-removal test, and cylinder rearing test, as well as a gait test, were performed to evaluate the therapeutic effects at 12 weeks after transplantation. Results The cells transplanted from the nose can enter brain tissue of rats 3 days after transplantation. The myelin sheath structure was more compact and the myelin sheath thickness was increased. The nerve function defect was improved 12 weeks after transplantation. Conclusions The intranasal administration of human oligodendrocyte progenitor cells had beneficial therapeutic effects on rehabilitation of the rat hypoxia-ischemia model. This technique is a potential strategy for applying oligodendrocyte progenitor cells in transplantation therapy against white matter injury.

Developmental trajectory of oligodendrocyte progenitor cells in the human brain revealed by single cell RNA sequencing

Glia ◽  
2020 ◽  
Vol 68 (6) ◽  
pp. 1291-1303 ◽  
Author(s):  
Kelly Perlman ◽  
Charles P. Couturier ◽  
Moein Yaqubi ◽  
Arnaud Tanti ◽  
Qiao‐Ling Cui ◽  
...  
Keyword(s):  
Human Brain ◽  
Single Cell ◽  
Progenitor Cells ◽  
Rna Sequencing ◽  
Developmental Trajectory ◽  
Oligodendrocyte Progenitor Cells ◽  
Oligodendrocyte Progenitor ◽  
Single Cell Rna Sequencing
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