Neutral and ion-pair silver(I) complexes of Schiff bases derived from methyl and ethyl carbazates with glyoxylic acid: Synthesis, structure, thermal behavior and cytotoxic activity

A series of 1,2,3-triazole, oxadiazole and aza-β-lactam derivatives were synthesized through consecutive reaction began from o-(N-propargyl) sulfonamido benzoic acid (1a). The reaction of (1a) with absolute ethanol in the presence of concentrated H2SO4 resulted in the formation of ester derivative (2a). The product of the previous reaction was reacted with 80% hydrazine hydrate to prepare benzohydrazide derivative (3a). 1,3,4-oxadiazole compound (4a) was obtained by condensation of compound (3a) with CS2 in presence KOH . Compound (3a) react with Phenyl isocyanates to give Carboxamide derivative (5a), that Condensation either with 2,4-dimethoxybenzaldhyde and p-hydroxybenzaldehyde to prepare the Schiff bases (6a-b). The cycloaddotion of Schiff-bases (6a-b) with phenyl isocyanate gave aza-β-lactams (7a-b). Benzamide derivatives (8a-c) were prepared via the reaction of compound (1a) with aniline derivatives, such as (p-toluidine, o-nitroaniline and m-nitroaniline). In a regioselective reaction 1,4-disubstituted-1,2,3-triazole derivative (9a-j) were synthesized via the click reaction of compounds 4a,5a and (8a-c) with benzyl azide and p-bromobenzyl azide. The compounds were identified using the spectral methods shown in the work. Cytotoxic effects of some final prepared compounds were studied in one cultured cellular models (MCF7 cell line) breast cancer (at various concentrations) by MTT assay, compound (9j) showed the better cytotoxic activity among the tested compounds.

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Ferroelectric Liquid Crystals: Synthesis and Thermal Behavior of Optically Active, Three-Ring Schiff Bases and Salicylaldimines

Chemistry - An Asian Journal ◽

10.1002/asia.201800119 ◽

2018 ◽

Vol 13 (8) ◽

pp. 1012-1023 ◽

Cited By ~ 11

Author(s):

Bhyranalyar N. Veerabhadraswamy ◽

Doddamane S. Shankar Rao ◽

Channabasaveshwar V. Yelamaggad

Keyword(s):

Liquid Crystals ◽

Thermal Behavior ◽

Schiff Bases ◽

Optically Active ◽

Ferroelectric Liquid Crystals

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Synthesis, characterization, thermal behavior, and DFT aspects of some oxovanadium(IV) complexes involving ONO-donor sugar Schiff bases

Journal of Coordination Chemistry ◽

10.1080/00958972.2014.959508 ◽

2014 ◽

Vol 67 (18) ◽

pp. 3084-3106 ◽

Cited By ~ 15

Author(s):

R.C. Maurya ◽

B.A. Malik ◽

J.M. Mir ◽

A.K. Sharma

Keyword(s):

Thermal Behavior ◽

Schiff Bases

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A study of glyoxylic acid synthesis in an undivided cell

Electrochimica Acta ◽

10.1016/0013-4686(90)87054-6 ◽

1990 ◽

Vol 35 (3) ◽

pp. 621-623 ◽

Cited By ~ 3

Author(s):

K. Scott ◽

A.P. Colbourne ◽

S.D. Perry

Keyword(s):

Glyoxylic Acid ◽

Acid Synthesis ◽

Undivided Cell

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Novel C-ring Analogs of Ursolic acid: Synthesis and Cytotoxic Evaluation

Natural Product Communications ◽

10.1177/1934578x1400901206 ◽

2014 ◽

Vol 9 (12) ◽

pp. 1934578X1400901

Author(s):

Uppuluri V. Mallavadhani ◽

Banita Pattnaik ◽

Nitasha Suri ◽

Ajit K. Saxena

Keyword(s):

Hela Cell ◽

Cytotoxic Activity ◽

Cell Line ◽

Cell Lines ◽

Ursolic Acid ◽

Parent Compound ◽

Acid Synthesis ◽

Hela Cell Line ◽

Hela Cell Lines ◽

Protective Groups

Ursolic acid (1), a natural pentacyclic triterpenic acid, afforded a variety of ring-C transformed products (5–11) when treated with N-bromosuccinimide under the influence of a range of protective groups and solvents. The synthesized compounds have been evaluated for cytotoxic activity against prostate PC 3, leukemia THP 1, cervical Hela and lung A-549 cancer cell lines. Among the tested analogs, compounds 5, 8, 9 and 10 showed potent activity against PC 3, THP 1 and Hela cell lines. Especially, compound 10 showed enhanced activity against the Hela cell line than the parent compound. Compounds 5, 8 and 9 showed comparable activities against PC 3 and THP 1 cell lines.

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