Novel C-ring Analogs of Ursolic acid: Synthesis and Cytotoxic Evaluation
2014 ◽
Vol 9
(12)
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pp. 1934578X1400901
Keyword(s):
Ursolic acid (1), a natural pentacyclic triterpenic acid, afforded a variety of ring-C transformed products (5–11) when treated with N-bromosuccinimide under the influence of a range of protective groups and solvents. The synthesized compounds have been evaluated for cytotoxic activity against prostate PC 3, leukemia THP 1, cervical Hela and lung A-549 cancer cell lines. Among the tested analogs, compounds 5, 8, 9 and 10 showed potent activity against PC 3, THP 1 and Hela cell lines. Especially, compound 10 showed enhanced activity against the Hela cell line than the parent compound. Compounds 5, 8 and 9 showed comparable activities against PC 3 and THP 1 cell lines.
2017 ◽
Keyword(s):
1995 ◽
Vol 108
(4)
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pp. 1617-1627
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Keyword(s):
2018 ◽
Vol 9
(2)
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Keyword(s):
2019 ◽
Vol 10
(2)
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pp. 51
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Keyword(s):
2021 ◽
Keyword(s):
Keyword(s):
Keyword(s):
2019 ◽
Vol 35
(3)
◽
pp. 080-1085
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Keyword(s):
2019 ◽
Vol 23
(07n08)
◽
pp. 908-915
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