Propofol acts on different sites than ethanol and butanol in recombinant glycine receptors: Evidence from pressure studies

2005 ◽  
Vol 1283 ◽  
pp. 312-314
Author(s):  
Daryl L. Davies ◽  
Daniel K. Crawford ◽  
James R. Trudell ◽  
Ronald L. Alkana
Keyword(s):  
Glycine Receptors

NMDA-coupled periaqueductal gray glycine receptors modulate anxioselective drug effects on plus-maze performance

1998 ◽  
Vol 90 (2) ◽  
pp. 157-165 ◽  
Author(s):  
Márcia Maria De Souza ◽  
Luiz Carlos Schenberg ◽  
Antonio de Pádua Carobrez
Keyword(s):  
Drug Effects ◽  
Periaqueductal Gray ◽  
Maze Performance ◽  
Glycine Receptors ◽  
Plus Maze

scholarly journals Presence of ethanol sensitive and insensitive glycine receptors in the ventral tegmental area and prefrontal cortex in mice

2021 ◽  
Author(s):  
Anibal Araya ◽  
Scarlet Gallegos ◽  
Rodrigo Viveros ◽  
Loreto San Martin ◽  
Braulio Muñoz ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Ventral Tegmental Area ◽  
Glycine Receptors ◽  
Ventral Tegmental

scholarly journals Anti-inflammatory activity of ivermectin in late-stage COVID-19 may reflect activation of systemic glycine receptors

Open Heart ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. e001655
Author(s):  
James J DiNicolantonio ◽  
Jorge Barroso-Aranda ◽  
Mark F McCarty
Keyword(s):  
Late Stage ◽  
Inflammatory Activity ◽  
Glycine Receptors ◽  
Anti Inflammatory

scholarly journals Zinc Enhances the Inhibitory Effects of Strychnine-Sensitive Glycine Receptors in Mouse Hippocampal Neurons

2007 ◽  
Vol 98 (6) ◽  
pp. 3666-3676 ◽  
Author(s):  
Hai Xia Zhang ◽  
Liu Lin Thio
Keyword(s):  
Action Potential ◽  
Action Potentials ◽  
Hippocampal Neurons ◽  
Neuronal Excitability ◽  
Hippocampal Slices ◽  
Glycine Receptors ◽  
Inhibitory Effects ◽  
Action Potential Firing ◽  
Embryonic Mouse ◽  
Potential Firing

Although extracellular Zn2+ is an endogenous biphasic modulator of strychnine-sensitive glycine receptors (GlyRs), the physiological significance of this modulation remains poorly understood. Zn2+ modulation of GlyR may be especially important in the hippocampus where presynaptic Zn2+ is abundant. Using cultured embryonic mouse hippocampal neurons, we examined whether 1 μM Zn2+, a potentiating concentration, enhances the inhibitory effects of GlyRs activated by sustained glycine applications. Sustained 20 μM glycine (EC25) applications alone did not decrease the number of action potentials evoked by depolarizing steps, but they did in 1 μM Zn2+. At least part of this effect resulted from Zn2+ enhancing the GlyR-induced decrease in input resistance. Sustained 20 μM glycine applications alone did not alter neuronal bursting, a form of hyperexcitability induced by omitting extracellular Mg2+. However, sustained 20 μM glycine applications depressed neuronal bursting in 1 μM Zn2+. Zn2+ did not enhance the inhibitory effects of sustained 60 μM glycine (EC70) applications in these paradigms. These results suggest that tonic GlyR activation could decrease neuronal excitability. To test this possibility, we examined the effect of the GlyR antagonist strychnine and the Zn2+ chelator tricine on action potential firing by CA1 pyramidal neurons in mouse hippocampal slices. Co-applying strychnine and tricine slightly but significantly increased the number of action potentials fired during a depolarizing current step and decreased the rheobase for action potential firing. Thus Zn2+ may modulate neuronal excitability normally and in pathological conditions such as seizures by potentiating GlyRs tonically activated by low agonist concentrations.

scholarly journals GLYCINE RECEPTOR ANTIBODY—A MARKER FOR NMO/ NON-MS DEMYELINATION?

2015 ◽  
Vol 86 (11) ◽  
pp. e4.36-e4
Author(s):  
Shahd Hamid ◽  
Liene Elsone ◽  
Patrick Waters ◽  
Mark Woodhall Woodhall ◽  
Kerry Mutch ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Neurological Disorders ◽  
Glycine Receptor ◽  
Prognostic Significance ◽  
Transverse Myelitis ◽  
Functional Disorders ◽  
Glycine Receptors ◽  
Cns Diseases ◽  
Receptor Antibody

BackgroundAntibodies against glycine receptors (GlyR Ab) have been strongly linked to progressive encephalomyelitis with rigidity and myoclonus (PERM). Their association with other neurological disorders is poorly understood.MethodsWe looked retrospectively at all patients who were tested for (GlyR Abs) in the Walton Centre between 2010–2014.Results138 patients were tested. The pre-test diagnoses (n) were transverse myelitis (34), NMO (22, (7 AQP4 IgG+ve and 15 AQP4 IgG-ve), optic neuritis (17), MS (22), ADEM (4), other atypical demyelination (4), encephalitis (11), epilepsy (4), dementia (4), parkinsonism (3), functional disorders (3) and others (10). 53.6% (74) had a relapsing course6/138 (4%) were positive for GlyR Ab. The diagnoses (n) were optic neuritis (2) one of which was AQP4 IgG+ve, NMO-AQP4-IgG negative (1), transverse myelitis (1), tumefactive demyelination (1) and undiagnosed spastic ataxic syndrome with normal imaging (1). 5/6 had a relapsing course and are on immunosuppressants.ConclusionAntibodies against GlyR are not common and seem to be associated with some non-PERM inflammatory CNS diseases, with a relapsing course. Larger studies are required to understand the clinical and prognostic significance of these early findings.

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