Safety of a weekly high dose of liposomal amphotericin B for prophylaxis of invasive fungal infection in immunocompromised patients: PROPHYSOME Study

ABSTRACTMucormycosis is a life-threatening fungal infection almost uniformly affecting diabetics in ketoacidosis or other forms of acidosis and/or immunocompromised patients. Inhalation ofMucoralesspores provides the most common natural route of entry into the host. In this study, we developed an intratracheal instillation model of pulmonary mucormycosis that hematogenously disseminates into other organs using diabetic ketoacidotic (DKA) or cyclophosphamide-cortisone acetate-treated mice. Various degrees of lethality were achieved for the DKA or cyclophosphamide-cortisone acetate-treated mice when infected with different clinical isolates ofMucorales. In both DKA and cyclophosphamide-cortisone acetate models, liposomal amphotericin B (LAmB) or posaconazole (POS) treatments were effective in improving survival, reducing lungs and brain fungal burdens, and histologically resolving the infection compared with placebo. These models can be used to study mechanisms of infection, develop immunotherapeutic strategies, and evaluate drug efficacies against life-threateningMucoralesinfections.

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Safety & Efficacy of Liposomal Amphotericin B Followed By Micafungin to Prevent Invasive Fungal Infection in Pediatric Allogeneic Stem Cell Transplantation Recipients

Biology of Blood and Marrow Transplantation ◽

10.1016/j.bbmt.2016.12.380 ◽

2017 ◽

Vol 23 (3) ◽

pp. S196-S197

Author(s):

Tishi Shah ◽

Mona Elmacken ◽

Tania Small ◽

Olga Militano ◽

Allyson Flower ◽

...

Keyword(s):

Stem Cell ◽

Stem Cell Transplantation ◽

Fungal Infection ◽

Amphotericin B ◽

Cell Transplantation ◽

Invasive Fungal Infection ◽

Allogeneic Stem Cell Transplantation ◽

Liposomal Amphotericin ◽

Liposomal Amphotericin B

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High-dose Weekly Liposomal Amphotericin B Antifungal Prophylaxis in Patients Undergoing Liver Transplantation

Transplantation Journal ◽

10.1097/tp.0000000000000393 ◽

2015 ◽

Vol 99 (4) ◽

pp. 848-854 ◽

Cited By ~ 13

Author(s):

Maddalena Giannella ◽

Giorgio Ercolani ◽

Francesco Cristini ◽

Mariacristina Morelli ◽

Michele Bartoletti ◽

...

Keyword(s):

Liver Transplantation ◽

Amphotericin B ◽

Liposomal Amphotericin ◽

Antifungal Prophylaxis ◽

Liposomal Amphotericin B ◽

High Dose

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Liposomal Amphotericin B, and Not Amphotericin B Deoxycholate, Improves Survival of Diabetic Mice Infected with Rhizopus oryzae

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.47.10.3343-3344.2003 ◽

2003 ◽

Vol 47 (10) ◽

pp. 3343-3344 ◽

Cited By ~ 65

Author(s):

Ashraf S. Ibrahim ◽

Valentina Avanessian ◽

Brad Spellberg ◽

John E. Edwards

Keyword(s):

Overall Survival ◽

Body Weight ◽

Amphotericin B ◽

Murine Model ◽

Liposomal Amphotericin ◽

Rhizopus Oryzae ◽

Liposomal Amphotericin B ◽

High Dose ◽

Diabetic Mice ◽

Amphotericin B Deoxycholate

ABSTRACT The efficacies of liposomal amphotericin B (LAmB) and amphotericin B deoxycholate (AmB) were compared in a diabetic murine model of hematogenously disseminated Rhizopus oryzae infection. At 7.5 mg/kg of body weight twice a day (b.i.d.), LAmB significantly improved overall survival compared to the rates of survival in both untreated control mice (P = 0.001) and mice treated with 0.5 mg of AmB per kg b.i.d. (P = 0.047). These data indicate that high-dose LAmB is more effective than AmB in treating murine disseminated zygomycosis.

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