Anticancer activity of silver and copper embedded chitin nanocomposites against human breast cancer (MCF-7) cells

2017 ◽  
Vol 105 ◽  
pp. 608-619 ◽  
Author(s):  
Dhanasekaran Solairaj ◽  
Palanivel Rameshthangam ◽  
Gnanapragasam Arunachalam
Keyword(s):  
Breast Cancer ◽  
Anticancer Activity ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Mcf 7

scholarly journals Graphene oxide and its nanocomposites with EDTA or chitosan induce apoptosis in MCF-7 human breast cancer

RSC Advances ◽  
2021 ◽  
Vol 11 (46) ◽  
pp. 29052-29064
Author(s):  
Ahmed S. Doghish ◽  
Gharieb S. El-Sayyad ◽  
Al-Aliaa M. Sallam ◽  
Waleed F. Khalil ◽  
Waleed M. A. El Rouby
Keyword(s):  
Breast Cancer ◽  
Acetic Acid ◽  
Graphene Oxide ◽  
Anticancer Activity ◽  
Human Breast Cancer ◽  
Ethylene Diamine ◽  
Human Breast ◽  
Mcf 7

To achieve the advanced anticancer activity of nanocomposites fabricated with graphene oxide (GO), a novel procedure was used during the fabrication of chitosan (CS) or ethylene diamine tetra acetic acid (EDTA).

scholarly journals Effects of substituents on anticancer activity of thiosemicarbazone against MCF-7 human breast cancer cell line

2020 ◽  
Author(s):  
Belay Zeleke Sibuh ◽  
Pankaj Taneja ◽  
Sonia Khanna
Keyword(s):  
Breast Cancer ◽  
Anticancer Activity ◽  
Cell Line ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
Mcf 7

AbstractBackground/AimBreast cancer is one of the world’s leading cause of deaths in women. This study evaluated the in-vitro anticancer activity of different thiosemicarbazones (HacTSc, HSTsc, 3-MBTSc, 4-NBTSc and 4-HBTSc) against MCF-7 human breast cancer cell line and MCF-10 normal cell.Materials and MethodsThe ligands were prepared and characterized by UV vis, IR, 1H NMR. MTT assay was used to determine cell viability. Then data were analyzed using two-way ANOVA with Tukey post-hoc test. Result: The ligands have IC50 value ranging from 2.271µg/ml to 7.081µg/ml. Acetone thiosemicarbazone and 3-Methoxybenzaldehyde thiosemicarbazone, were identified as the most potent against MCF-7 breast cancer cells with IC50 value of 2.271µg/ml and 2.743µg/ml respectively. Whereas 4-Nitrobenzaldehyde thiosemicarbazone was the least potent. Also, the IC50 of the normal MCF-10 cell indicated their activity were selective. Conclusion: The activity of the ligands were dose, position and substituents dependent. Acetone thiosemicarbazone and 3-Methoxybenzaldehyde thiosemicarbazone are promising anticancer agents for further study.

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