Biodegradable double cross-linked chitosan hydrogels for drug delivery: Impact of chemistry on rheological and pharmacological performance

2020 ◽  
Vol 165 ◽  
pp. 2205-2218
Author(s):  
Nieves Iglesias ◽  
Elsa Galbis ◽  
Concepción Valencia ◽  
M. Jesús Díaz-Blanco ◽  
Bertrand Lacroix ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chitosan Hydrogels ◽  
Double Cross

scholarly journals Modified chitosan hydrogels as drug delivery and tissue engineering systems: present status and applications

2012 ◽  
Vol 2 (5) ◽  
pp. 439-449 ◽  
Author(s):  
Tapan Kumar Giri ◽  
Amrita Thakur ◽  
Amit Alexander ◽  
Ajazuddin ◽  
Hemant Badwaik ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Present Status ◽  
Engineering Systems ◽  
Modified Chitosan ◽  
Chitosan Hydrogels

A smart multifunctional drug delivery nanoplatform for targeting cancer cells

Nanoscale ◽  
2016 ◽  
Vol 8 (25) ◽  
pp. 12723-12728 ◽  
Author(s):  
M. Hoop ◽  
F. Mushtaq ◽  
C. Hurter ◽  
X.-Z. Chen ◽  
B. J. Nelson ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Stimuli Responsive ◽  
Chitosan Hydrogels

Nanomachines incorporating stimuli-responsive chitosan hydrogels are engineered as a platform for multifunctional and wirelessly guided drug delivery to cancer cells.

In Situ Precipitation of Amorphous Calcium Phosphate and Ciprofloxacin Crystals during the Formation of Chitosan Hydrogels and Its Application for Drug Delivery Purposes

Langmuir ◽  
2012 ◽  
Vol 28 (45) ◽  
pp. 15937-15946 ◽  
Author(s):  
Stefania Nardecchia ◽  
María C. Gutiérrez ◽  
M. Concepción Serrano ◽  
Mariella Dentini ◽  
Andrea Barbetta ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Chitosan Hydrogels

Norbornene-Functionalised Chitosan Hydrogels and Microgels via an Unprecedented Photo-Initiated Self-Assembly for Potential Biomedical Applications

2020 ◽  
Author(s):  
Sarah michel ◽  
Alice Kilner ◽  
Jean-Charles Eloi ◽  
Sarah E rogers ◽  
Wuge H. Briscoe ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Hydrophobic Interactions ◽  
Gelation Mechanism ◽  
Swelling Behaviour ◽  
Assembly Mechanism ◽  
Significant Toxicity ◽  
Chitosan Hydrogels

<p><br></p><p> Access to biocompatible self-assembled gels and microgels is of great interests for a variety of biological applications from tissue engineering to drug delivery. Here, the facile synthesis of supramolecular hydrogels of norbornene (nb)-functionalised chitosan (CS-nb) via UV-triggered self-assembly in the presence of Irgacure 2959 (IRG) is reported. The <i>in vitro </i>stable hydrogels are injectable and showed pH-responsive swelling behaviour, while their structure and mechanical properties could be tuned by tailoring the stereochemistry of the norbornene derivative (e.g. <i>endo</i>- or -<i>exo</i>). Interestingly, unlike other nb-type hydrogels, the gels possess nanopores within their structure, which might lead to potential drug delivery applications. A gelation mechanism was proposed based on hydrophobic interactions following the combination of IRG on norbornene, as supported by 1H NMR. This self-assembly mechanism was used to access microgels of size 100-150 nm which could be further functionalised and showed no significant toxicity to human dermofibroblast cells. </p>

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