A novel low-molecular-weight chitosan/gamma-polyglutamic acid polyplexes for nucleic acid delivery into zebrafish larvae

Хитозан и его производные обладают множеством свойств, которые позволяют применять его в пчеловодстве. Он повышает устойчивость организма пчел к неблагоприятным факторам внешней среды и к возбудителям различных заболеваний. В результате проведенных исследований разработаны технологические параметры получения низкомолекулярного хитозана методом ферментативного гидролиза. Chitosan and its derivatives have many properties that allow them to be used in beekeeping. It increases the resistance of the bee organism to adverse environmental factors and to pathogens of various diseases. As a result of the conducted research, the technological parameters for the production of low-molecular-weight chitosan by enzymatic hydrolysis were developed.

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Low Molecular Weight Chitosan Prevents the Progression of Low Dose Streptozotocin-Induced Slowly Progressive Diabetes Mellitus in Mice.

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.23.1458 ◽

2000 ◽

Vol 23 (12) ◽

pp. 1458-1464 ◽

Cited By ~ 68

Author(s):

Yoichi KONDO ◽

Akiko NAKATANI ◽

Koji HAYASHI ◽

Mikio ITO

Keyword(s):

Diabetes Mellitus ◽

Molecular Weight ◽

Low Dose ◽

Low Molecular Weight ◽

Low Molecular Weight Chitosan

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Effect of kinetin on nucleic acid synthesis in senescing and young leaves in Brassica oleracea L. var. gongylodes L.

Acta Societatis Botanicorum Poloniae ◽

10.5586/asbp.1975.051 ◽

2015 ◽

Vol 44 (4) ◽

pp. 553-565

Author(s):

J. Legocka ◽

A. Szweykowska

Keyword(s):

Molecular Weight ◽

Nucleic Acid ◽

Acid Synthesis ◽

Inhibitory Effect ◽

Rrna Synthesis ◽

Low Molecular Weight ◽

Chlorophyll B ◽

Mature Leaves ◽

Young Leaves ◽

Brassica Oleracea L

In detached kohlrabi leaves senescing in the dark, the decrease in chlorophyll to was more pronounced than in chlorophyll a. The retardation by kinetin of the chlorophyll loss was also markedly stronger in the case of chlorophyll b. Using the fractionation of nucleic acids on polyacrylamide gels it has been shown that during leaf senescence the level of all RNA species decreased, whereas the amount of DNA was more or less constant. In the presence of kinetin, the loss of RNA was inhibited and the incorporation of precursor into the cytoplasmic rRNA as well as into low molecular weight RNA species was supported. Chloroplast rRNA synthesis has not been detected in mature leaves and kinetin showed no effect in this respect. In young expanding leaves detached and kept in light, the synthesis of cytoplasmic rRNA was strongly stimulated by kinetin, whereas in the case of Chloroplast rRNA only an inhibitory effect of kinetin could be found. The results suggest that the cytokinins are primarily involved in processes of the synthesis of cytoplasmic rRNA and low molecular RNA fractions, and in this way affect the development of plastids, in particular the course of their senescence.

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