Effects of thyroxin therapy on cardiac function in patients with subclinical hypothyroidism: index of myocardial performance in the evaluation of left ventricular function

2004 ◽  
Vol 95 (2-3) ◽  
pp. 135-143 ◽  
Author(s):  
Mehmet Yazici ◽  
Sevket Gorgulu ◽  
Yasar Sertbas ◽  
Enver Erbilen ◽  
Sinan Albayrak ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Subclinical Hypothyroidism ◽  
Left Ventricular ◽  
Myocardial Performance

Effect ofL-thyroxine on left ventricular function in subclinical hypothyroidism

2015 ◽  
Author(s):  
Valentina Velkoska Nakova ◽  
Brankica Krstevska ◽  
Elizabeta Srbinovska Kostovska ◽  
Gordana Pemovska
Keyword(s):  
Left Ventricular Function ◽  
Ventricular Function ◽  
Subclinical Hypothyroidism ◽  
Left Ventricular

Importance of the Index of Myocardial Performance in Evaluation of Left Ventricular Function

2002 ◽  
Vol 19 (4) ◽  
pp. 273-278 ◽  
Author(s):  
Sinan Dagdelen ◽  
Nevnihal Eren ◽  
Hasan Karabulut ◽  
Nuri Caglar
Keyword(s):  
Left Ventricular Function ◽  
Ventricular Function ◽  
Left Ventricular ◽  
Myocardial Performance

scholarly journals Environmentally persistent free radicals decrease cardiac function and increase pulmonary artery pressure

2012 ◽  
Vol 303 (9) ◽  
pp. H1135-H1142 ◽  
Author(s):  
Sarah Mahne ◽  
Gin C. Chuang ◽  
Edward Pankey ◽  
Lucy Kiruri ◽  
Philip J. Kadowitz ◽  
...  
Keyword(s):  
Free Radicals ◽  
Left Ventricle ◽  
Cardiac Function ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Diastolic Pressure ◽  
Silica Particles ◽  
Left Ventricular ◽  
Heme Oxygenase 1 ◽  
Stroke Work

Epidemiological studies have consistently linked inhalation of particulate matter (PM) to increased cardiac morbidity and mortality, especially in at risk populations. However, few studies have examined the effect of PM on baseline cardiac function in otherwise healthy individuals. In addition, airborne PM contain environmentally persistent free radicals (EPFR) capable of redox cycling in biological systems. The purpose of this study was to determine whether nose-only inhalation of EPFRs (20 min/day for 7 days) could decrease baseline left ventricular function in healthy male Sprague-Dawley rats. The model EPFR tested was 1,2-dichlorobenzene chemisorbed to 0.2-μm-diameter silica/CuO particles at 230°C (DCB230). Inhalation of vehicle or silica particles served as controls. Twenty-four hours after the last exposure, rats were anesthetized (isoflurane) and ventilated (3 l/min), and left ventricular function was assessed using pressure-volume catheters. Compared with controls, inhalation of DCB230 significantly decreased baseline stroke volume, cardiac output, and stroke work. End-diastolic volume and end-diastolic pressure were also significantly reduced; however, ventricular contractility and relaxation were not changed. DCB230 also significantly increased pulmonary arterial pressure and produced hyperplasia in small pulmonary arteries. Plasma levels of C-reactive protein were significantly increased by exposure to DCB230, as were levels of heme oxygenase-1 and SOD2 in the left ventricle. Together, these data show that inhalation of EPFRs, but not silica particles, decreases baseline cardiac function in healthy rats by decreasing cardiac filling, secondary to increased pulmonary resistance. These EPFRs also produced systemic inflammation and increased oxidative stress markers in the left ventricle.

The effect of milrinone on right and left ventricular function when used as a rescue therapy for term infants with pulmonary hypertension

2015 ◽  
Vol 26 (1) ◽  
pp. 90-99 ◽  
Author(s):  
Adam T. James ◽  
John D. Corcoran ◽  
Patrick J. McNamara ◽  
Orla Franklin ◽  
Afif F. El-Khuffash
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Right Ventricle ◽  
Left Ventricular Function ◽  
Strain Rate ◽  
Ventricular Function ◽  
Left Ventricular ◽  
Inhaled Nitric Oxide ◽  
Persistent Pulmonary Hypertension ◽  
Myocardial Performance

AbstractIntroductionMilrinone may be an appropriate adjuvant therapy for infants with persistent pulmonary hypertension of the newborn. We aimed to describe the effect of milrinone administration on right and left ventricular function in infants with persistent pulmonary hypertension not responding to inhaled nitric oxide after 4 hours of administration.Materials and methodsThis is a retrospective review of infants born after or at 34 weeks of gestation with persistent pulmonary hypertension who received milrinone treatment. The primary endpoint was the effect of milrinone on myocardial performance and haemodynamics, including right and left ventricular outputs, tissue Doppler velocities, right ventricle and septal strain, and strain rate. Secondary endpoints examined included duration of inhaled nitric oxide and oxygen support.ResultsA total of 17 infants with a mean (standard deviation) gestation and birth weight of 39.8 (2.0) weeks and 3.45 (0.39) kilograms, respectively, were included in the study. The first echocardiogram was performed 15 hours after the commencement of nitric oxide inhalation. Milrinone treatment was started at a median time of 1 hour after the echocardiogram and was associated with an increase in left ventricular output (p=0.04), right ventricular output (p=0.004), right ventricle strain (p=0.01) and strain rate (p=0.002), and left ventricle s` (p<0.001) and a` (p=0.02) waves. There was a reduction in nitric oxide dose and oxygen requirement over the subsequent 72 hours (all p<0.05).ConclusionThe use of milrinone as an adjunct to nitric oxide is worth further exploration, with preliminary evidence suggesting an improvement in both oxygenation and myocardial performance in this group of infants.

Recovery of Systolic and Diastolic Left Ventricular Function Early after Cardiopulmonary Bypass

1996 ◽  
Vol 85 (5) ◽  
pp. 1063-1075 ◽  
Author(s):  
Stefan G. De Hert ◽  
Inez E. Rodrigus ◽  
Luc R. Haenen ◽  
Peter A. De Mulder ◽  
Thierry C. Gillebert
Keyword(s):  
Cardiopulmonary Bypass ◽  
Cardiac Function ◽  
Left Ventricular Function ◽  
Diastolic Function ◽  
Ventricular Function ◽  
Systolic Pressure ◽  
Left Ventricular ◽  
Stiffness Constant ◽  
Diastolic Left Ventricular Function ◽  
Volume Relation

Background Impairment of left ventricular function after cardiopulmonary bypass (CPB) is well recognized, but little is known about the time course of recovery of cardiac function early after separation from CPB. Therefore, recovery of left ventricular function was evaluated early after separation from CPB in patients undergoing coronary artery surgery. The authors tried to determine whether this recovery might be attributed to autoregulation of function by preload. Methods Left ventricular pressure was measured with fluid-filled catheters. Data were digitally recorded during increased pressure induced by elevating the legs. Transgastric short-axis echocardiographic views of the left ventricle were simultaneously recorded on videotape. Systolic function was evaluated with the slope (Ees, mmHg/ml) of the systolic pressure-volume relation. Diastolic function was evaluated with the chamber stiffness constant (Kc, ml-1) of the diastolic pressure-volume relation. Cardiac function was assessed before CPB, after termination of CPB, and 5, 10, and 15 min later. Two different separation procedures from CPB were compared: in protocol 1, left ventricular function was documented during the standard procedure (n = 24); in protocol 2, the heart was optimally filled 10 min before separation from CPB (n = 12). Results In protocol 1, Ees was 2.88 +/- 0.21 mmHg/ml (mean +/- SEM) and Kc was 0.012 +/- 0.001 ml-1 before CPB. Within 10 min after separation from CPB, Ees increased from 1.10 +/- 0.32 to 2.92 +/- 0.34 (P = 0.001) and Kc decreased from 0.022 +/- 0.002 to 0.011 +/- 0.001 (P = 0.001). The parameters remained stable thereafter. In protocol 2, Ees was 2.92 +/- 0.51 mmHg/ ml and Kc was 0.011 +/- 0.002 ml-1 before CPB. Depression of systolic and diastolic function was not observed in these patients. At time 0, Ees was 2.46 +/- 0.16 and Kc was 0.012 +/- 0.002. These values remained stable throughout the entire observation period. Conclusions Significant functional recovery was observed early after separation from CPB, which was suggestive of time-dependent changes in both systolic and diastolic left ventricular function induced by preload restoration.

scholarly journals Uloga Swan-Ganz PA katetera u proceni hemodinamskih promena tokom hirurske revaskularizacije miokarda u bolesnika sa oslabljenom funkcijom leve komore

2002 ◽  
Vol 49 (1) ◽  
pp. 27-35 ◽  
Author(s):  
M. Jovic ◽  
Zoran Popovic ◽  
Dusko Nezic ◽  
V. Ilic ◽  
Sinisa Gradinac ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Repeated Measures ◽  
Artery Bypass ◽  
Randomized Study ◽  
Oxygen Metabolism ◽  
Left Ventricular ◽  
Group A ◽  
Group B

Coronary artery bypass surgery in patient with bad left ventricular function is a challenge for surgical time. Specially important is monitoring of haemodynamics. We performed this open, prospective, randomized study with the aim to assess haemodynamics and oxygen profile monitoring. 34 pts for coronary surgery (EF < 40%) were divided in two groups. Group A, 17 pts. Received glucose-insulin-potassium (GIK) solution. Group B, 127 pts. Received Ringer solution. Haemodynamic and oxygen metabolism parameters were measured in four time points. I after the induction in anesthesia; II after the operation; III 6 hours post op.; IV 24 hour post op. Data are expressed as mean +/-SD, ANOVA for repeated measures followed by Newman-Keuls testing were used. In both groups were evident deterioration of cardiac function during first 6h as well as VO2 and DO:, more prominent in Group B. Significant recovery and improvement of cardiac function were evident in Group A after 24 h. CI during the time in Group A improves significantly (2.14+/-0.36 v. 3.05+/-0.55; p=0.0002) and difference during the time between groups was p=0,005. LVSWI improved significantly during the time him Group A (AIII vs. AIV) p=0.007. Simultaneously. VO improves significantly in Group A (103+/-21 vs. 164+/-30, p=0.00001) while difference between groups in DO was p=0.037. Importance of oxygen metabolism monitoring for both, left ventricular function and haemodynamics assessment was evident in our study.

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