Enhanced external counterpulsation improves endothelium-dependent vasorelaxation in the carotid arteries of hypercholesterolemic pigs

2006 ◽  
Vol 112 (3) ◽  
pp. 269-274 ◽  
Author(s):  
Jun Tao ◽  
Chang Tu ◽  
Zhen Yang ◽  
Yan Zhang ◽  
Xiao-Lin Chung ◽  
...  

2021 ◽  
Vol 8 ◽  
Author(s):  
Yahui Zhang ◽  
Ziqi Chen ◽  
Zhouming Mai ◽  
Wenjuan Zhou ◽  
Hui Wang ◽  
...  

Purpose: Enhanced external counterpulsation is a non-invasive treatment that increases coronary flow in patients with coronary artery disease (CAD). However, the acute responses of vascular and blood flow characteristics in the conduit arteries during and immediately after enhanced external counterpulsation (EECP) need to be verified.Methods: Forty-two patients with CAD and 21 healthy controls were recruited into this study to receive 45 min-EECP. Both common carotid arteries (CCAs), namely, the left carotid (LC) and right carotid (RC), the right brachial (RB), and right femoral (RF) artery were imaged using a Color Doppler ultrasound. The peak systolic velocity (PSV), end-diastolic velocity (EDV), mean inner diameter (ID), resistance index (RI), and mean flow rate (FR) were measured and calculated before, during, and after the 45 min-EECP treatment.Results: During EECP, in the CCAs, the EDV was significantly decreased, while the RI was markedly increased in the two groups (both P < 0.01). However, immediately after EECP, the RI in the RC was significantly lower than that at the baseline in the patients with CAD (P = 0.039). The FR of the LC was markedly increased during EECP only in the CAD patients (P = 0.004). The PSV of the patients with CAD was also significantly reduced during EECP (P = 0.015) and immediately after EECP (P = 0.005) compared with the baseline. Moreover, the ID of the LC, RB, and RF was significantly higher immediately after EECP than that at the baseline (all P < 0.05) in the patients with CAD. In addition, they were also higher than that in the control groups (all P < 0.05). Furthermore, by the subgroup analysis, there were significant differences in the FR, PSV, and RI between females and males during and immediately after EECP (all P < 0.05).Conclusions: Enhanced external counterpulsation creates different responses of vascular and blood flow characteristics in carotid and peripheral arteries, with more significant effects in both the carotid arteries. Additionally, the beneficial effects in ID, blood flow velocity, RI, and FR after 45 min-EECP were shown only in the patients with CAD. More importantly, acute improvement of EECP in the FR of the brachial artery was showed in males, while the FR and RI of the carotid arteries changed in females.



2010 ◽  
Vol 65 (2) ◽  
pp. 265-267
Author(s):  
M. Tarpgaard Jørgensen ◽  
C. Gerdes ◽  
O. May


2021 ◽  
Vol 77 (18) ◽  
pp. 43
Author(s):  
Mehak Aggarwal ◽  
John Spertus ◽  
Robert Kaplan ◽  
Sachin Shah


Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Sachin A Shah ◽  
Bradley R Williams ◽  
Atiera Andrews-Pestana

Introduction: Enhanced External Counterpulsation (EECP) is a non-invasive Food and Drug Administration approved treatment for patients with chronic stable angina and heart failure. Typical treatment regimen comprises of 35, 1-hour sessions of synchronized compressions of the calf, thigh, and sacral muscles over a seven-week period. Exercise duration measured using an exercise tolerance test is a commonly utilized marker of worsening ischemic disease and is predictive of cardiovascular mortality. Several studies have evaluated the impact of EECP on exercise duration with conflicting results. We sought to determine the magnitude of benefit of EECP on exercise duration. Methods: A literature search was performed in MEDLINE, CINAHL, and the Cochrane database along with hand searching of relevant articles limited to those published in the English language. Studies were included for analyses if assessing patients with stable angina and reporting exercise duration data using either the Bruce or modified Bruce exercise treadmill test. Appropriate data were extracted at baseline and after completion of the full course of EECP. Studies were excluded if presenting duplicate data or using a non-Bruce protocol. A weighted mean difference from baseline along with 95% confidence interval was calculated using the DerSimonian-Laird random-effects model. Sub-group analyses, the Cochran Q statistic, and JADAD scores were utilized to assess for heterogeneity, non-combinability, and quality of published studies respectively. Publication bias was assessed using visual inspection of funnel plots and the Egger bias statistic. Results: Our search strategy identified 1117 independent studies of which 15 were included for analyses. A total of 484 individual subjects were incorporated in the primary analysis. Exercise duration improved by 55.5 seconds (95%CI 36.1 to 74.9; Cochran Q, p=0.246) from baseline. The benefits were maintained when using a fixed-effects model, excluding small studies and limiting to studies using the Bruce protocol only. While the Egger statistic showed a lack of publication bias (p=0.121), it cannot be ruled out based on visual inspection of funnel plots. Conclusion: EECP significantly increases exercise duration by 56 seconds in patients with chronic stable angina. Further studies are needed to determine the impact of EECP on long-term outcomes. The views expressed in this material are those of the authors, and do not reflect the official policy or position of the U.S. Government, the Department of Defense or the Department of the Air Force.



2010 ◽  
Vol 65 (2) ◽  
pp. 239-247 ◽  
Author(s):  
V. Kitsou ◽  
T. Xanthos ◽  
R. Roberts ◽  
G.M. Karlis ◽  
L. Padadimitriou


2006 ◽  
Vol 19 (8) ◽  
pp. 867-872 ◽  
Author(s):  
J LEVENSON ◽  
M PERNOLLET ◽  
M ILIOU ◽  
M DEVYNCK ◽  
A SIMON


2015 ◽  
Vol 47 ◽  
pp. 755
Author(s):  
Paloma D. Sardina ◽  
Joseph C. Avery ◽  
Jeffrey S. Martin ◽  
Randy W. Braith ◽  
Gaith Larguech


2004 ◽  
Vol 79 (5) ◽  
pp. 690-692 ◽  
Author(s):  
Piero O. Bonetti ◽  
Suresh N. Gadasalli ◽  
Amir Lerman ◽  
Gregory W. Barsness




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