Prognostic value of neutrophil gelatinase-associated lipocalin in acute heart failure

Acute heart failure continues to be a worldwide medical problem, associated with frequent readmissions, high mortality, and a profound economic impact on national health care systems. In the past decade, biomarkers have shifted the way in which acute heart failure is managed by the cardiologist. The search for the ideal biomarker to aid in the diagnosis, prognosis, and treatment of acute heart failure is ongoing. The natriuretic peptides have proved extremely useful in determining whether acute dyspnoea has a cardiac aetiology. In addition, recent trials have demonstrated the use of natriuretic peptides in inpatient and outpatient prognosis, as well as in titrating medications in outpatients with chronic heart failure to prevent acute heart failure hospitalizations. Other emerging acute heart failure biomarkers include mid-regional pro-adrenomedullin, mid-regional proatrial natriuretic peptide, troponin, ST2, and neutrophil gelatinase-associated lipocalin.

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Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: The NGAL EvaLuation Along with B-type NaTriuretic Peptide in acutely decompensated heart failure (GALLANT) trial

European Journal of Heart Failure ◽

10.1093/eurjhf/hfr087 ◽

2011 ◽

Vol 13 (8) ◽

pp. 846-851 ◽

Cited By ~ 175

Author(s):

Alan S. Maisel ◽

Christian Mueller ◽

Robert Fitzgerald ◽

Robert Brikhan ◽

Brian C. Hiestand ◽

...

Keyword(s):

Heart Failure ◽

Acute Heart Failure ◽

Natriuretic Peptide ◽

Decompensated Heart Failure ◽

Neutrophil Gelatinase Associated Lipocalin ◽

Acutely Decompensated Heart Failure ◽

Prognostic Utility ◽

Neutrophil Gelatinase

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Biomarkers in acute heart failure

10.1093/med/9780199687039.003.0037_update_003 ◽

2018 ◽

Author(s):

Rajiv Choudhary ◽

Kevin Shah ◽

Alan Maisel

Keyword(s):

Heart Failure ◽

Acute Heart Failure ◽

Health Care Systems ◽

Medical Problem ◽

National Health Care ◽

Neutrophil Gelatinase Associated Lipocalin ◽

Acute Dyspnoea ◽

Care Systems ◽

Neutrophil Gelatinase ◽

The Ideal

Acute heart failure continues to be a worldwide medical problem, associated with frequent readmissions, high mortality, and a profound economic impact on national health care systems. In the past decade, biomarkers have shifted the way in which acute heart failure is managed by the cardiologist. The search for the ideal biomarker to aid in the diagnosis, prognosis, and treatment of acute heart failure is ongoing. The natriureticfc peptides have proved extremely useful in determining whether acute dyspnoea has a cardiac aetiology. In addition, recent trials have demonstrated the use of natriuretic peptides in inpatient and outpatient prognosis, as well as in titrating medications in outpatients with chronic heart failure to prevent acute heart failure hospitalizations. Other emerging acute heart failure biomarkers include mid-regional pro-adrenomedullin, mid-regional proatrial natriuretic peptide, troponin, ST2, and neutrophil gelatinase-associated lipocalin.

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NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN PROVIDES ADDITIONAL PROGNOSTIC UTILITY TO HIGH-SENSITIVITY CARDIAC TROPONIN I IN ACUTE HEART FAILURE

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(19)31382-8 ◽

2019 ◽

Vol 73 (9) ◽

pp. 774

Author(s):

Jeremy Kong ◽

Yu Horiuchi ◽

Nicholas Wettersten ◽

Patrick Murray ◽

Alan Maisel

Keyword(s):

Heart Failure ◽

Acute Heart Failure ◽

Cardiac Troponin ◽

Troponin I ◽

High Sensitivity ◽

Cardiac Troponin I ◽

Neutrophil Gelatinase Associated Lipocalin ◽

Prognostic Utility ◽

Neutrophil Gelatinase

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The role of urine neutrophil gelatinase – associated lipocalin (NGAL) in acute heart failure in patients with ST – elevation myocardial infarction

BMC Cardiovascular Disorders ◽

10.1186/s12872-015-0054-9 ◽

2015 ◽

Vol 15 (1) ◽

Cited By ~ 13

Author(s):

Simona Kirbiš ◽

Maksimiljan Gorenjak ◽

Andreja Sinkovič

Keyword(s):

Myocardial Infarction ◽

Heart Failure ◽

Acute Heart Failure ◽

St Elevation Myocardial Infarction ◽

Neutrophil Gelatinase Associated Lipocalin ◽

St Elevation ◽

Neutrophil Gelatinase

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Plasma Neutrophil Gelatinase-Associated Lipocalin and Predicting Clinically Relevant Worsening Renal Function in Acute Heart Failure

International Journal of Molecular Sciences ◽

10.3390/ijms18071470 ◽

2017 ◽

Vol 18 (7) ◽

pp. 1470 ◽

Cited By ~ 8

Author(s):

Kevin Damman ◽

Mattia Valente ◽

Dirk van Veldhuisen ◽

John Cleland ◽

Christopher O’Connor ◽

...

Keyword(s):

Heart Failure ◽

Renal Function ◽

Acute Heart Failure ◽

Neutrophil Gelatinase Associated Lipocalin ◽

Worsening Renal Function ◽

Neutrophil Gelatinase

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Urine Biomarkers Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) Have Different Patterns in Heart Failure Exacerbation

Biomarker Insights ◽

10.4137/bmi.s11479 ◽

2013 ◽

Vol 8 ◽

pp. BMI.S11479 ◽

Cited By ~ 18

Author(s):

Meyeon Park ◽

Eric Vittinghoff ◽

Kathleen D. Liu ◽

Michael G. Shlipak ◽

Chi-yuan Hsu

Keyword(s):

Heart Failure ◽

Renal Function ◽

Acute Heart Failure ◽

Kidney Injury ◽

Renal Recovery ◽

Neutrophil Gelatinase Associated Lipocalin ◽

Urine Biomarkers ◽

Heart Failure Exacerbation ◽

Kidney Injury Molecule 1 ◽

Neutrophil Gelatinase

Individuals with acute heart failure exacerbation often experience a deterioration in renal function. We sought to determine whether this deterioration is ischemic in nature and detectable by sensitive urine biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1). We measured serial biomarker levels and evaluated the associations of these biomarkers with renal recovery in a cohort of hospitalized patients with acute heart failure exacerbation.

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