Background:
A number of studies have proposed that lncRNA XIST plays a role in the development and
chemosensitivity of NSCLC. Besides, XIST may become a potential therapeutic target for NSCLC patients. The aim of this
review is to reveal the biological functions and exact mechanisms of XIST in NSCLC.
Methods:
In this review, relevant researches involving in the relationship between XIST and NSCLC are collected through
systematic retrieval of PubMed
Results:
XIST is an oncogene in NSCLC and is abnormally upregulated in NSCLC tissues. Considerable evidence has
shown that XIST exerts a critical role in the proliferation, invasion, migration, apoptosis and chemosensitivity of NSCLC
cells. XIST mainly functions as a ceRNA in NSCLC process, while XIST also functions at transcriptional levels.
Conclusion:
LncRNA XIST has potential to become a novel biomolecular marker of NSCLC and a therapeutic target for
NSCLC.
