scholarly journals Proteomic profiling reveals a distinctive molecular signature for critically ill COVID-19 patients compared with asthma and COPD

2022 ◽  
Author(s):  
Zili Zhang ◽  
Fanjie Lin ◽  
Fei Liu ◽  
Qiongqiong Li ◽  
Yuanyuan Li ◽  
...  
Keyword(s):  
Critically Ill ◽  
Molecular Signature ◽  
Proteomic Profiling

scholarly journals Proteomic Profiling of Bronchoalveolar Lavage Fluid in Critically Ill Patients with Ventilator-Associated Pneumonia

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58782 ◽  
Author(s):  
Elizabeth V. Nguyen ◽  
Sina A. Gharib ◽  
Steven J. Palazzo ◽  
Yu-hua Chow ◽  
David R. Goodlett ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Ventilator Associated Pneumonia ◽  
Proteomic Profiling

Molecular signature of coronary stent thrombosis: oxidative stress and innate immunity cells

2017 ◽  
Vol 117 (09) ◽  
pp. 1816-1827 ◽  
Author(s):  
Judit Cubedo ◽  
Ana Blasco ◽  
Teresa Padró ◽  
Ilaria Ramaiola ◽  
Oriol Juan-Babot ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stent Thrombosis ◽  
Redox Homeostasis ◽  
Immunohistochemical Analysis ◽  
Serum Levels ◽  
Recurrent Event ◽  
Molecular Signature ◽  
Regulatory Subunit ◽  
Proteomic Profiling ◽  
Related Proteins

SummaryThe clinical impact of in-stent thrombosis is high because it is associated with high mortality and 20 % of the patients suffer a recurrent event within the two following years. The aim of this study was to characterise the morphologic and proteomic profile of in-stent thrombi (IST) in comparison to thrombi developed on native coronary arteries (CT) to identify a differential molecular signature. The study included 45 patients with ST-elevation-myocardial-infarction (STEMI) treated by primary-percutaneous-intervention and thrombus aspiration: 21 had IST and 24 had CT. Thrombi were characterised by morphologic immunohistochemical analysis and differential proteomic profiling (2-DE+MALDI-TOF/TOF). Bioinformatic analysis revealed differences in proteins related to oxidative-stress and cell death/survival. IST showed a higher content of structural proteins (gelsolin, actin-cytoplasmic-1, tropomyosin, and myosin) together with an imbalance in redox-homeostasis related proteins (increased superoxide-dismutase and decreased peroxiredoxin-2 thrombus content), and a coordinated increase of chaperones (HSP60 and HSC70) and cellular quality control-related proteins (26S–protease-regulatory-subunit-7). These changes were reflected into a significant decrease in HSC70 systemic levels and a significant increase in advanced-oxidation-protein-products (AOPP) indicative of increased oxidative stress-mediated protein damage in IST. Our results reveal an imbalance in redox-related proteins indicative of an exacerbated oxidative-stress that leads to an accumulation of AOPP serum levels in IST. Moreover, the coordinated increase in chaperones and regulatory proteins reflects the activation of intracellular protection mechanisms to maintain protein integrity in IST. The failure to counterbalance the stress situation could trigger cellular apoptosis leading to the destabilization of the thrombus and to a worse prognosis of IST-STEMI-patients.Supplementary Material to this article is available online at www.thrombosis-online.com.

TRACHEOSTOMY IN CRITICALLY ILL NEUROSURGICAL PATIENTS

2001 ◽  
Vol 5 (1) ◽  
pp. A5-A5
Author(s):  
Keith Y.C. Goh ◽  
Wendy Teoh ◽  
Chumpon Chan
Keyword(s):  
Critically Ill ◽  
Neurosurgical Patients

How Can Caregivers for the Critically Ill Avoid Burnout?

1988 ◽  
Vol 33 (7) ◽  
pp. 603-603
Author(s):  
Timothy P. Carmody
Keyword(s):  
Critically Ill

Social Support and Functioning Among Mothers of Critically Ill Children

2008 ◽  
Author(s):  
Christine Rini ◽  
Sharon Manne ◽  
Katherine Duhamel ◽  
Jane Austin ◽  
Jamie Ostroff ◽  
...  
Keyword(s):  
Social Support ◽  
Critically Ill ◽  
Critically Ill Children
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