scholarly journals Antimycobacterial activity of medicinal plants against the causative agent of buruli ulcer: Mycobacterium ulcerans

2016 ◽  
Vol 5 ◽  
pp. S105 ◽  
Author(s):  
R. Keumoe ◽  
M.S. Nguembou ◽  
F.P.V. Tsouh ◽  
D.V.F. Donkeng ◽  
D. Dize ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Causative Agent ◽  
Buruli Ulcer ◽  
Antimycobacterial Activity ◽  
Mycobacterium Ulcerans

scholarly journals Mycobacterium ulceransin Mosquitoes and March flies captured from endemic areas of Northern Queensland, Australia

2018 ◽  
Author(s):  
Avishek Singh ◽  
William John Hannan McBride ◽  
Brenda Govan ◽  
Mark Pearson ◽  
Scott A. Ritchie
Keyword(s):  
Causative Agent ◽  
Buruli Ulcer ◽  
Mycobacterial Infection ◽  
Blood Feeding ◽  
Mycobacterium Ulcerans ◽  
Mechanical Transmission ◽  
Environmental Reservoir ◽  
Nontuberculous Mycobacterial Infection ◽  
Mode Of Transmission ◽  
Endemic Areas

AbstractMycobacterium ulceransis the causative agent of Buruli ulcer (BU). This nontuberculous mycobacterial infection has been reported in over 33 countries worldwide. In Australia, the majority of cases of BU have been recorded in coastal Victoria and the Mossman-Daintree areas of north Queensland. Mosquitoes have been postulated as a vector ofM. ulceransin Victoria, however the specific mode of transmission of this disease is still far from being well understood. In the current study, we trapped and analysed 16,900 (allocated to 845 pools) mosquitoes and 296 March flies from the endemic areas of north Queensland to examine for the presence ofM. ulceransDNA by polymerase chain reaction. Seven of 845 pools of mosquitoes were positive on screening using the IS2404 PCR target but only one pool was positive for presence ofM. ulceransafter confirmatory testing. None of the March fly samples were positive for the presence ofM. ulcerans.M. ulceranswas detected on proboscises of deliberately exposed mosquitoes.Author SummaryThe causative agent of Buruli ulcer is Mycobacterium ulcerans. This destructive skin disease is characterized by extensive and painless necrosis of skin and underlying tissues usually on extremities of body due to production of toxin named mycolactone. The disease is prevalent in Africa and coastal Australia. The exact mode of transmission and potential environmental reservoir for the pathogen still remain obscure. Aquatic and biting insects have been identified as important niche in transmission and maintenance of pathogen in the environment. In this study we screened mosquitoes and march flies captured from endemic areas of northern Queensland for the presence ofM. ulcerans.In addition, we conducted artificial blood feeding experiment to identify the role of mosquitoes in transmission of this pathogen. We found one pool of mosquito out of 845 pools positive forM. ulceransand none of the March fly samples were positive. This could indicate a low burden of the bacteria in the environment coinciding with a comparatively low number of human cases ofM. ulceransinfection seen during the trapping period of the study. Evidence to support mechanical transmission via mosquito proboscises was found.

scholarly journals Beninese Medicinal Plants as a Source of Antimycobacterial Agents: Bioguided Fractionation andIn VitroActivity of Alkaloids Isolated fromHolarrhena floribundaUsed in Traditional Treatment of Buruli Ulcer

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Achille Yemoa ◽  
Joachim Gbenou ◽  
Dissou Affolabi ◽  
Mansourou Moudachirou ◽  
André Bigot ◽  
...  
Keyword(s):  
Buruli Ulcer ◽  
Cost Effective ◽  
Antimycobacterial Activity ◽  
Mycobacterium Ulcerans ◽  
Traditional Treatment ◽  
Aerial Parts ◽  
Antimycobacterial Agents ◽  
Pharmacologically Active ◽  
Hydroethanolic Extract

Buruli ulcer (BU) imposes a serious economic burden on affected households and on health systems that are involved in diagnosing the disease and treating patients. Research is needed to find cost-effective therapies for this costly disease. Plants have always been an important source of new pharmacologically active molecules. Consequently we decided to undertake the study of plants used in traditional treatment of BU in Benin and investigate their antimycobacterial activity as well as their chemical composition. Extracts from forty-four (44) plant species were selected on account of reported traditional uses for the treatment of BU in Benin and were assayed for antimycobacterial activities. Crude hydroethanolic extract from aerial parts ofHolarrhena floribunda(G. Don) T. Durand and Schinz was found to have significant antimycobacterial activity againstM.ulcerans(MIC = 125 µg/mL). We describe here the identification of four steroidal alkaloids fromMycobacterium ulceransgrowth-inhibiting fractions of the alkaloidal extract of the aerial parts ofHolarrhena floribunda. Holadysamine was purified in sufficient amount to allow the determination of its MCI (=50 µg/mL). These results give some support to the use of this plant in traditional medicine.

scholarly journals Draft Genome Sequence of Mycobacterium ulcerans S4018 Isolated from a Patient with an Active Buruli Ulcer in Benin, Africa

2017 ◽  
Vol 5 (17) ◽  
Author(s):  
Stanimir Kambarev ◽  
Stéphane Corvec ◽  
Annick Chauty ◽  
Estelle Marion ◽  
Laurent Marsollier ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Causative Agent ◽  
Cutaneous Lesion ◽  
Draft Genome ◽  
Buruli Ulcer ◽  
Mycobacterium Ulcerans ◽  
Tropical Disease ◽  
Draft Genome Sequence ◽  
Content Type

ABSTRACT Currently, there are only two publicly available genomes of Mycobacterium ulcerans—the causative agent of the neglected, but devastating, tropical disease Buruli ulcer. Here, we report the draft genome sequence of isolate S4018, recovered from an active cutaneous lesion of a patient with Buruli ulcer in Benin, Africa.

scholarly journals Evidences of the low implication of mosquitoes in the transmission of Mycobacterium ulcerans, the causative agent of Buruli ulcer

2018 ◽  
Vol 73 ◽  
pp. 74
Author(s):  
F. Zeukeng ◽  
R. Djouaka ◽  
J. Bigoga ◽  
R. Adeoti ◽  
M. Tamo ◽  
...  
Keyword(s):  
Causative Agent ◽  
Buruli Ulcer ◽  
Mycobacterium Ulcerans

A comparison of DNA extraction procedures for the detection of Mycobacterium ulcerans, the causative agent of Buruli ulcer, in clinical and environmental specimens

2009 ◽  
Vol 76 (2) ◽  
pp. 152-158 ◽  
Author(s):  
Lies Durnez ◽  
Pieter Stragier ◽  
Karen Roebben ◽  
Anthony Ablordey ◽  
Herwig Leirs ◽  
...  
Keyword(s):  
Dna Extraction ◽  
Causative Agent ◽  
Buruli Ulcer ◽  
Mycobacterium Ulcerans ◽  
Extraction Procedures

scholarly journals Seasonal Pattern of Mycobacterium ulcerans, the Causative Agent of Buruli Ulcer, in the Environment in Ghana

2017 ◽  
Vol 74 (2) ◽  
pp. 350-361 ◽  
Author(s):  
Samuel Yaw Aboagye ◽  
Kobina Assan Ampah ◽  
Amanda Ross ◽  
Prince Asare ◽  
Isaac Darko Otchere ◽  
...  
Keyword(s):  
Causative Agent ◽  
Seasonal Pattern ◽  
Buruli Ulcer ◽  
Mycobacterium Ulcerans

scholarly journals Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer

2007 ◽  
Vol 17 (2) ◽  
pp. 192-200 ◽  
Author(s):  
T. P. Stinear ◽  
T. Seemann ◽  
S. Pidot ◽  
W. Frigui ◽  
G. Reysset ◽  
...  
Keyword(s):  
Causative Agent ◽  
Buruli Ulcer ◽  
Mycobacterium Ulcerans ◽  
Reductive Evolution ◽  
Niche Adaptation

scholarly journals On the origin of Mycobacterium ulcerans, the causative agent of Buruli ulcer

BMC Genomics ◽  
2012 ◽  
Vol 13 (1) ◽  
pp. 258 ◽  
Author(s):  
Kenneth D Doig ◽  
Kathryn E Holt ◽  
Janet AM Fyfe ◽  
Caroline J Lavender ◽  
Miriam Eddyani ◽  
...  
Keyword(s):  
Causative Agent ◽  
Buruli Ulcer ◽  
Mycobacterium Ulcerans

scholarly journals Ecological niche modelling of Hemipteran insects in Cameroon; the paradox of a vector-borne transmission for Mycobacterium ulcerans, the causative agent of Buruli ulcer

2014 ◽  
Vol 13 (1) ◽  
pp. 44 ◽  
Author(s):  
Kevin Carolan ◽  
Solange Meyin À Ebong ◽  
Andres Garchitorena ◽  
Jordi Landier ◽  
Daniel Sanhueza ◽  
...  
Keyword(s):  
Causative Agent ◽  
Ecological Niche ◽  
Buruli Ulcer ◽  
Ecological Niche Modelling ◽  
Mycobacterium Ulcerans ◽  
Niche Modelling ◽  
Vector Borne
Sign in / Sign up

Export Citation Format

Share Document