A functional understanding of moderate to complex congenital heart disease and the impact of pregnancy. Part I: The transposition complexes

Mothers of children with congenital heart disease (CHD) tend to be concerned about their child’s normal life. The majority of these mothers tend to experience negative psychological problems. In this study, the adaptation process of mothers raising a child with complex CHD was investigated based on the sociocultural context of Korea. The data collection was conducted by in-depth interviews and theoretical sampling was performed until the data were saturated. The collected data were analyzed using continuous theoretical comparisons. The results of the present study showed that the core category in the mothers’ adaptation process was ‘anxiety regarding the future’, and the mothers’ adaptation process consisted of the impact phase, standing against phase, and accepting phase. In the impact phase, the participants emotionally fluctuated between ‘feelings of abandonment’ and ‘entertaining hope’. In the standing against phase, participants tended to dedicate everything to child-rearing while being affected by ‘being encouraged by support’ and ‘being frustrated by tasks beyond their limits’. In the accepting phase, the subjects attempted to ‘accept the child as is’, ‘resist hard feelings’, and ‘share hope’. Health-care providers need to develop programs that include information regarding CHD, how to care for a child with CHD, and effective child-rearing behaviors.

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New Insights into the Impact of Genome-Wide Copy Number Variations on Complex Congenital Heart Disease in Saudi Arabia

OMICS A Journal of Integrative Biology ◽

10.1089/omi.2019.0165 ◽

2020 ◽

Vol 24 (1) ◽

pp. 16-28 ◽

Cited By ~ 1

Author(s):

Majed J. Dasouki ◽

Salma M. Wakil ◽

Olfat Al-Harazi ◽

Maarab Alkorashy ◽

Nzioka P. Muiya ◽

...

Keyword(s):

Congenital Heart Disease ◽

Saudi Arabia ◽

Heart Disease ◽

Copy Number ◽

Congenital Heart ◽

Copy Number Variations ◽

Complex Congenital Heart Disease ◽

Genome Wide ◽

The Impact

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Impact of hepatopathy in pediatric patients after surgery for complex congenital heart disease

PLoS ONE ◽

10.1371/journal.pone.0248776 ◽

2021 ◽

Vol 16 (3) ◽

pp. e0248776

Author(s):

Torben Kehl ◽

Daniel Biermann ◽

Andrea Briem-Richter ◽

Gerhard Schoen ◽

Jakob Olfe ◽

...

Keyword(s):

Liver Transplantation ◽

Congenital Heart Disease ◽

Heart Disease ◽

Organ Dysfunction ◽

Congenital Heart ◽

Heart Rhythm ◽

Complex Congenital Heart Disease ◽

Control Group ◽

Heart Rhythm Disorders ◽

The Impact

Patients undergoing complex pediatric cardiac surgery in early infancy are at risk of postoperative secondary end-organ dysfunction. The aim of this study was to determine specific risk factors promoting the development of peri- and postoperative hepatopathy after surgery for congenital heart disease. In this retrospective study, we identified 20 consecutive patients operated between 2011 and 2019 from our institutional cohort who developed significant postsurgical hepatic dysfunction. These patients were compared to a control group of 30 patients with comparable initial cardiac conditions and STS-EACTS risk score. Patients who developed hepatopathy in the intensive care unit have chronic cholestasis and decreased liver synthesis. The impact of postoperative hepatopathy on morbidity was marked. In six patients (30%), liver transplantation was executed as ultima ratio, and two (10%) were listed for liver transplantation. The overall mortality related to postoperative hepatopathy is high: We found nine patients (45%) having severe hepatopathy and mostly multiple organ dysfunction who died in the postoperative course. According to risk analysis, postoperative right and left heart dysfunction in combination with a postoperative anatomical residuum needing a re-operation or re-intervention in the postoperative period is associated with a high risk for the development of cardiac hepatopathy. Furthermore, postoperative complications (pleural effusion, heart rhythm disorders, etc.), postoperative infections, and the need for parenteral nutrition also raise the risk for cardiac hepatopathy. Further investigations are needed to reduce hepatic complications and improve the general prognosis of such complex patients.

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Double-chambered left ventricle with complex congenital heart disease in an infant: an extremely rare pathology

CHILDREN’S HEART AND VASCULAR DISEASES ◽

10.24022/1810-0686-2019-16-3-187-191 ◽

2019 ◽

Vol 16 (3) ◽

pp. 187-191

Author(s):

T.V. Rogova ◽

A.I. Kim ◽

A.V. Sobolev ◽

S.A. Aleksandrova ◽

E.V. Kholmanskaya ◽

...

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Left Ventricle ◽

Congenital Heart ◽

Complex Congenital Heart Disease

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End‐of‐life care for children with complex congenital heart disease: Parents' and medical care givers' perceptions

Journal of Paediatrics and Child Health ◽

10.1111/jpc.15316 ◽

2020 ◽

Author(s):

Caterina Agosto ◽

Francesca Benedetti ◽

Valentina De Tommasi ◽

Ornella Milanesi ◽

Giovanni Stellin ◽

...

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Medical Care ◽

End Of Life ◽

End Of Life Care ◽

Congenital Heart ◽

Complex Congenital Heart Disease ◽

Life Care ◽

Care Givers

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The impact of medical interventions on admission characteristics in children with congenital heart disease and cardiomyopathy

Cardiology in the Young ◽

10.1017/s1047951120004175 ◽

2020 ◽

pp. 1-8

Author(s):

Rohit S. Loomba ◽

Jacqueline Rausa ◽

Vincent Dorsey ◽

Ronald A. Bronicki ◽

Enrique G. Villarreal ◽

...

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Length Of Stay ◽

Congenital Heart ◽

Unit Length ◽

Channel Blockers ◽

Regression Analyses ◽

Converting Enzyme Inhibitors ◽

Medical Interventions ◽

The Impact

Abstract Introduction: Children with congenital heart disease and cardiomyopathy are a unique patient population. Different therapies continue to be introduced with large practice variability and questionable outcomes. The purpose of this study is to determine the impact of various medications on intensive care unit length of stay, total length of stay, billed charges, and mortality for admissions with congenital heart disease and cardiomyopathy. Materials and methods: We identified admissions of paediatric patients with cardiomyopathy using the Pediatric Health Information System database. The admissions were then separated into two groups: those with and without inpatient mortality. Univariate analyses were conducted between the groups and the significant variables were entered as independent variables into the regression analyses. Results: A total of 10,376 admissions were included these analyses. Of these, 904 (8.7%) experienced mortality. Comparing patients who experienced mortality with those who did not, there was increased rate of acute kidney injury with an odds ratio (OR) of 5.0 [95% confidence interval (CI) 4.3 to 5.8, p < 0.01], cardiac arrest with an OR 7.5 (95% CI 6.3 to 9.0, p < 0.01), and heart transplant with an OR 0.3 (95% CI 0.2 to 0.4, p < 0.01). The medical interventions with benefit for all endpoints after multivariate regression analyses in this cohort are methylprednisolone, captopril, enalapril, furosemide, and amlodipine. Conclusions: Diuretics, steroids, angiotensin-converting enzyme inhibitors, calcium channel blockers, and beta blockers all appear to offer beneficial effects in paediatric cardiomyopathy admission outcomes. Specific agents within each group have varying effects.

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