In vivo-vitalisation of beta-tricalcium phosphate scaffolds for primary reconstruction of segmental mandibular defects: an experimental pilot study in sheep

2009 ◽  
Vol 38 (5) ◽  
pp. 506
Author(s):  
H. Kokemueller ◽  
M. Nolff ◽  
S. Spalthoff ◽  
H. Essig ◽  
E.L. Barth ◽  
...  
Keyword(s):  
Pilot Study ◽  
Tricalcium Phosphate ◽  
Primary Reconstruction ◽  
Beta Tricalcium Phosphate

Melatonin decorated 3D-printed beta-tricalcium phosphate scaffolds promoting bone regeneration in a rat calvarial defect model

2019 ◽  
Vol 7 (20) ◽  
pp. 3250-3259 ◽  
Author(s):  
Yali Miao ◽  
Yunhua Chen ◽  
Xiao Liu ◽  
Jingjing Diao ◽  
Naru Zhao ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Calvarial Defect ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
3D Printed ◽  
Rat Calvarial Defect

3D-printed β-TCP scaffolds decorated with melatonin via dopamine mussel-inspired chemistry enhance the osteogenesis and in vivo bone regeneration.

scholarly journals Activation of NLRP3 Inflammasome Complexes by Beta-Tricalcium Phosphate Particles and Stimulation of Immune Cell Migration in vivo

2021 ◽  
pp. 1-11
Author(s):  
Kouji Maruyama ◽  
Jin-Yan Cheng ◽  
Hidee Ishii ◽  
Yu Takahashi ◽  
Vincent Zangiacomi ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tricalcium Phosphate ◽  
Nlrp3 Inflammasome ◽  
Immune Cell ◽  
Dependent Manner ◽  
Potassium Efflux ◽  
Beta Tricalcium Phosphate ◽  
Immune Cell Migration ◽  
Deficient Mice

Beta-tricalcium phosphate (β-TCP) serves as a bone substitute in clinical practice because it is resorbable, biocompatible, osteointegrative, and osteoconductive. Particles of β-TCP are also inflammatory mediators although the mechanism of this function has not been fully elucidated. Regardless, the ability of β-TCP to stimulate the immune system might be useful for immunomodulation. The present study aimed to determine the effects of β-TCP particles on NLR family pyrin domain containing 3 (NLRP3) inflammasome complexes. We found that β-TCP activates NLRP3 inflammasomes, and increases interleukin (IL)-1β production in primary cultured mouse dendritic cells (DCs) and macrophages, and human THP-1 cells in caspase-1 dependent manner. In THP-1 cells, β-TCP increased also IL-18 production, and NLRP3 inflammasome activation by β-TCP depended on phagocytosis, potassium efflux, and reactive oxygen species (ROS) generation. We also investigated the effects of β-TCP in wild-type and NLRP3-deficient mice in vivo. Immune cell migration around subcutaneously injected β-TCP particles was reduced in NLRP3-deficient mice. These findings suggest that the effects of β-TCP particles in vivo are at least partly mediated by NLRP3 inflammasome complexes.

scholarly journals REACTION OF POROUS HYDROXYAPATITE COATED WITH β-TRICALCIUM PHOSPHATE IN VIVO

1994 ◽  
Vol 4 (0) ◽  
pp. 59-64
Author(s):  
Koji IOKU ◽  
Hisashi KUROSAWA ◽  
Kazuyuki SHIBUYA ◽  
Hitoshi YOKOZEKI ◽  
Taketo HAYASHI
Keyword(s):  
Tricalcium Phosphate ◽  
Porous Hydroxyapatite ◽  
Beta Tricalcium Phosphate
Sign in / Sign up

Export Citation Format

Share Document