Early-phase migration dynamics of Echinococcus multilocularis in two mouse strains showing different infection susceptibilities

The characteristics of the mononuclear phagocytes mediating resistance to infection with Listeria during the early phase (0 to 48 h) of the response have been investigated in genetically determined susceptible (A/J) and resistant (C57BL/6, B10.A/SgSn) strains of mice. Irradiation immediately before infection profoundly enhanced the bacterial growth in the resistant strain, while having no effect in the susceptible strain, over a wide range (3 x 10(3) to 10(5)) of infective doses. This effect of irradiation is demonstrable at low-dose radiation (200 roentgens) and can be reversed by repopulation with 20 x 10(6) syngeneic nucleated bone marrow cells. Administration of dextran sulfate 500 24 h before infection profoundly enhanced the bacterial growth in the susceptible strain, while having much less effect in the resistant strain. Thus, the genetic advantage of the resistant mouse strains to listerial infection, at least during the early phase of the response, appears to be due to a cellular mechanism that is highly radiosensitive and relatively insensitive to dextran sulfate 500. In the susceptible strain, the early protective cellular mechanism is radioresistant and highly dextran sulfate 500 sensitive.

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Echinococcus multilocularis: mouse strain difference in hydatid development

Journal of Helminthology ◽

10.1017/s0022149x00000791 ◽

1997 ◽

Vol 71 (1) ◽

pp. 53-56 ◽

Cited By ~ 14

Author(s):

K. Nakaya ◽

M. Nakao ◽

A. Ito

Keyword(s):

Mouse Strain ◽

Echinococcus Multilocularis ◽

Strain Difference ◽

Qualitative Difference ◽

Inbred Strains ◽

Mouse Strains ◽

Female Mice

AbstractFemale mice of nine inbred strains (A, AKR, BALB/c, C3H, C57BL/6, C57BL/10, CBA, DBA/1 and DBA/2) and H-2 congenic B10.D2, at 9–10 weeks of age, were infected with larval Echinococcus multilocularis by trans-portal injection of hydatid homogenate. Parasitized livers were histologically examined 9 or 13 weeks after infection. Hydatid development was quite different among mouse strains. Multivesiculation was prominent in C57BL/10, DBA/1, C57BL/6 and BALB/c. Protoscoleces were well developed in DBA/2, AKR, DBA/1 and CBA. H-2 congenic B10.D2, which has the background genes of C57BL/10 except for the H-2d gene of DBA/2, resembled C57BL/10 in prohibiting the development of protoscoleces. These data suggest that the qualitative difference in hydatid development may be regulated by non-H-2 gene(s).

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Echinococcus multilocularis: parasite-specific humoral and cellular immune response subsets in mouse strains susceptible (AKR, C57BI/6J) or‘resistant’(C57B1/10) to secondary alveolar echinococcosis

Clinical & Experimental Immunology ◽

10.1111/j.1365-2249.1994.tb06549.x ◽

2008 ◽

Vol 96 (2) ◽

pp. 245-252 ◽

Cited By ~ 41

Author(s):

B. GOTTSTEIN ◽

E. WUNDERLIN ◽

I. TANNER

Keyword(s):

Immune Response ◽

Echinococcus Multilocularis ◽

Cellular Immune Response ◽

Alveolar Echinococcosis ◽

Mouse Strains ◽

Cellular Immune

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Hematological parameters in the early phase of influenza A virus infection in differentially susceptible inbred mouse strains

BMC Research Notes ◽

10.1186/s13104-015-1195-8 ◽

2015 ◽

Vol 8 (1) ◽

Cited By ~ 4

Author(s):

Matthias Preusse ◽

Klaus Schughart ◽

Esther Wilk ◽

Frank Klawonn ◽

Frank Pessler

Keyword(s):

Virus Infection ◽

Influenza A Virus ◽

Early Phase ◽

Influenza A ◽

Hematological Parameters ◽

Inbred Mouse ◽

Mouse Strains ◽

Inbred Mouse Strains ◽

Influenza A Virus Infection

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Echinococcus multilocularis: Relationship between persistent inflammation, serum amyloid a protein response and amyloidosis in four mouse strains

Experimental Parasitology ◽

10.1016/0014-4894(88)90080-x ◽

1988 ◽

Vol 67 (2) ◽

pp. 334-345 ◽

Cited By ~ 10

Author(s):

Z Ali-Khan ◽

Jean D Sipe ◽

Tao Du ◽

H Riml

Keyword(s):

Echinococcus Multilocularis ◽

Serum Amyloid A ◽

Serum Amyloid ◽

Mouse Strains ◽

Amyloid A ◽

Persistent Inflammation ◽

Serum Amyloid A Protein ◽

Protein Response

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Alterations in the number of motoneurons containing immunoreactive calcitonin gene-related peptide(CGRP)& choline acetyltransferase(ChAT) in the cervical spinal cord of the wobbler mouse during the development of the motoneuron disease

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100141226 ◽

1995 ◽

Vol 53 ◽

pp. 970-971

Author(s):

L. Vacca-Galloway ◽

Y.Q. Zhang ◽

P. Bose ◽

S.H. Zhang

Keyword(s):

Spinal Cord ◽

Early Stage ◽

Cervical Spinal Cord ◽

Wild Type Mouse ◽

Reflex Response ◽

Mouse Strains ◽

Behavioral Tests ◽

Wobbler Mouse ◽

Stage 4 ◽

Stage 1

The Wobbler mouse (wr) has been studied as a model for inherited human motoneuron diseases (MNDs). Using behavioral tests for forelimb power, walking, climbing, and the “clasp-like reflex” response, the progress of the MND can be categorized into early (Stage 1, age 21 days) and late (Stage 4, age 3 months) stages. Age-and sex-matched normal phenotype littermates (NFR/wr) were used as controls (Stage 0), as well as mice from two related wild-type mouse strains: NFR/N and a C57BI/6N. Using behavioral tests, we also detected pre-symptomatic Wobblers at postnatal ages 7 and 14 days. The mice were anesthetized and perfusion-fixed for immunocytochemical (ICC) of CGRP and ChAT in the spinal cord (C3 to C5).Using computerized morphomety (Vidas, Zeiss), the numbers of IR-CGRP labelled motoneurons were significantly lower in 14 day old Wobbler specimens compared with the controls (Fig. 1). The same trend was observed at 21 days (Stage 1) and 3 months (Stage 4). The IR-CGRP-containing motoneurons in the Wobbler specimens declined progressively with age.

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