Phase transition water-in-oil microemulsions as ocular drug delivery systems: In vitro and in vivo evaluation

2007 ◽  
Vol 328 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Judy Chan ◽  
Gamal M.M. El Maghraby ◽  
Jennifer P. Craig ◽  
Raid G. Alany
Keyword(s):  
Phase Transition ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
In Vivo Evaluation

Chitosan Nanoparticles as New Ocular Drug Delivery Systems: In Vitro Stability, in Vivo Fate, and Cellular Toxicity

2005 ◽  
Vol 22 (6) ◽  
pp. 1007-1007 ◽  
Author(s):  
Angela M. de Campos ◽  
Yolanda Diebold ◽  
Edison L. S. Carbalho ◽  
Alejandro Sánchez ◽  
María José Alonso
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Chitosan Nanoparticles ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
Cellular Toxicity ◽  
In Vitro Stability

Chitosan Nanoparticles as New Ocular Drug Delivery Systems: in Vitro Stability, in Vivo Fate, and Cellular Toxicity

2004 ◽  
Vol 21 (5) ◽  
pp. 803-810 ◽  
Author(s):  
Angela M. de Campos ◽  
Yolanda Diebold ◽  
Edison L. S. Carvalho ◽  
Alejandro Sánchez ◽  
Maria José Alonso
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Chitosan Nanoparticles ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
Cellular Toxicity ◽  
In Vitro Stability

scholarly journals Bimatoprost-Loaded Ocular Inserts as Sustained Release Drug Delivery Systems for Glaucoma Treatment: In Vitro and In Vivo Evaluation

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e95461 ◽  
Author(s):  
Juçara Ribeiro Franca ◽  
Giselle Foureaux ◽  
Leonardo Lima Fuscaldi ◽  
Tatiana Gomes Ribeiro ◽  
Lívia Bomfim Rodrigues ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
In Vivo Evaluation ◽  
Release Drug ◽  
Glaucoma Treatment

scholarly journals Mechanisms and Pharmaceutical Action of Lipid Nanoformulation of Natural Bioactive Compounds as Efficient Delivery Systems in the Therapy of Osteoarthritis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1108
Author(s):  
Oana Craciunescu ◽  
Madalina Icriverzi ◽  
Paula Ecaterina Florian ◽  
Anca Roseanu ◽  
Mihaela Trif
Keyword(s):  
Drug Delivery ◽  
Bioactive Compounds ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Joint Disease ◽  
Duration Of Action ◽  
Immune System Activation

Osteoarthritis (OA) is a degenerative joint disease. An objective of the nanomedicine and drug delivery systems field is to design suitable pharmaceutical nanocarriers with controllable properties for drug delivery and site-specific targeting, in order to achieve greater efficacy and minimal toxicity, compared to the conventional drugs. The aim of this review is to present recent data on natural bioactive compounds with anti-inflammatory properties and efficacy in the treatment of OA, their formulation in lipid nanostructured carriers, mainly liposomes, as controlled release systems and the possibility to be intra-articularly (IA) administered. The literature regarding glycosaminoglycans, proteins, polyphenols and their ability to modify the cell response and mechanisms of action in different models of inflammation are reviewed. The advantages and limits of using lipid nanoformulations as drug delivery systems in OA treatment and the suitable route of administration are also discussed. Liposomes containing glycosaminoglycans presented good biocompatibility, lack of immune system activation, targeted delivery of bioactive compounds to the site of action, protection and efficiency of the encapsulated material, and prolonged duration of action, being highly recommended as controlled delivery systems in OA therapy through IA administration. Lipid nanoformulations of polyphenols were tested both in vivo and in vitro models that mimic OA conditions after IA or other routes of administration, recommending their clinical application.

Self-assembled drug delivery systems. Part 6: In vitro/in vivo studies of anticancer N-octadecanoyl gemcitabine nanoassemblies

2012 ◽  
Vol 430 (1-2) ◽  
pp. 276-281 ◽  
Author(s):  
Yiguang Jin ◽  
Yanju Lian ◽  
Lina Du ◽  
Shuangmiao Wang ◽  
Chang Su ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
In Vivo Studies ◽  
Self Assembled
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