Novel magnetic iron oxide nanoparticles coated with poly(ethylene imine)-g-poly(ethylene glycol) for potential biomedical application: Synthesis, stability, cytotoxicity and MR imaging

Novel method for synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) coated with polyethylenimine (PEI) and modified with poly(ethylene glycol) methyl ether (MPEG), MPEG-PEI-SPIONs, was developed. PEI-SPIONs were successfully prepared in aqueous system via photochemistry, and their surface was modified with poly(ethylene glycol) methyl ether (MPEG). The so-obtained MPEG-PEI-SPIONs had a uniform hydrodynamic particle size of 34 nm. The successful coating of MPEG-PEI on the SPIONs was ascertained from FT-IR analysis, and the PEI and MPEG fractions in MPEG-PEI-SPIONs were calculated to account for 31% and 12%, respectively. Magnetic measurement revealed that the saturated magnetization of MPEG-PEI-SPIONs reached 46 emu/g and the nanoparticles showed the characteristic of being superparamagnetic. The stability experiment revealed that the MPEG-PEI modification improved the nanoparticles stability greatly.T2 relaxation measurements showed that MPEG-PEI-SPIONs show similarR2 value to the PEI-SPIONs. TheT2-weighted magnetic resonance imaging (MRI) of MPEG-PEI-SPIONs showed that the magnetic resonance signal was enhanced significantly with increasing nanoparticle concentration in water. These results indicated that the MPEG-PEI-SPIONs had great potential for application in MRI.

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Structure and Properties of Iron Oxide Nanoparticles Encapsulated by Phospholipids with Poly(ethylene glycol) Tails

The Journal of Physical Chemistry C ◽

10.1021/jp075235c ◽

2007 ◽

Vol 111 (49) ◽

pp. 18078-18086 ◽

Cited By ~ 61

Author(s):

Eleonora V. Shtykova ◽

Xinlei Huang ◽

Nicholas Remmes ◽

David Baxter ◽

Barry Stein ◽

...

Keyword(s):

Iron Oxide ◽

Ethylene Glycol ◽

Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Structure And Properties ◽

Poly Ethylene Glycol ◽

Poly Ethylene

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Advantages of poly(vinyl phosphonic acid)-based double hydrophilic block copolymers for the stabilization of iron oxide nanoparticles

Polymer Chemistry ◽

10.1039/c6py01558a ◽

2016 ◽

Vol 7 (41) ◽

pp. 6391-6399 ◽

Cited By ~ 12

Author(s):

K. H. Markiewicz ◽

L. Seiler ◽

I. Misztalewska ◽

K. Winkler ◽

S. Harrisson ◽

...

Keyword(s):

Iron Oxide ◽

Block Copolymers ◽

Ethylene Glycol ◽

Iron Oxide Nanoparticles ◽

Phosphonic Acid ◽

Oxide Nanoparticles ◽

Poly Ethylene Glycol ◽

Double Hydrophilic Block Copolymers ◽

Vinylphosphonic Acid ◽

Poly Ethylene

Poly(ethylene glycol)–poly(vinylphosphonic acid) double hydrophilic block copolymers were synthesized by RAFT/MADIX polymerization and used to prepare stable iron oxide nanoparticles.

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Multi-functional nanocarriers based on iron oxide nanoparticles conjugated with doxorubicin, poly(ethylene glycol) and folic acid as theranostics for cancer therapy

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2018.06.051 ◽

2018 ◽

Vol 170 ◽

pp. 529-537 ◽

Cited By ~ 11

Author(s):

S. Rajkumar ◽

M. Prabaharan

Keyword(s):

Folic Acid ◽

Iron Oxide ◽

Cancer Therapy ◽

Ethylene Glycol ◽

Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Poly Ethylene Glycol ◽

Poly Ethylene

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A mussel-inspired chitooligosaccharide based multidentate ligand for highly stabilized nanoparticles

Journal of Materials Chemistry B ◽

10.1039/c5tb00114e ◽

2015 ◽

Vol 3 (18) ◽

pp. 3730-3737 ◽

Cited By ~ 14

Author(s):

Chichong Lu ◽

Min Kyu Park ◽

Chenxin Lu ◽

Young Haeng Lee ◽

Kyu Yun Chai

Keyword(s):

Iron Oxide ◽

Ethylene Glycol ◽

Iron Oxide Nanoparticles ◽

Biomedical Applications ◽

Oxide Nanoparticles ◽

Poly Ethylene Glycol ◽

Multidentate Ligand ◽

Poly Ethylene

A mussel-inspired poly(ethylene glycol)-grafted-chitooligosaccharide based multidentate ligand (ML) is designed for preparing robust biocompatible iron oxide nanoparticles. The successful in vivo MRI application confirmed their suitability for biomedical applications.

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