Amino acid based amphiphilic copolymer micelles as carriers of non-steroidal anti-inflammatory drugs: Solubilization, in vitro release and biological evaluation

Norbornene-functional poly(lactide)s backbone-based amphiphilic copolymer, P(LA-g-mOEG)-b-P(LA-SS-COOH), was synthesized as the polymeric scaffold and paclitaxel (PTX) was directly conjugated to the carboxyl groups of the amphiphilic copolymer to obtain redox-responsive P(LA-g-mOEG)-b-P(LA-SS-PTX) prodrugs. The dynamic light scattering and transmission electron microscopy analyses showed that P(LA-g-mOEG)-b-P(LA-SS-PTX) self-assembled into prodrug micelles with a diameter of 60–70 nm and a low polydispersity in aqueous solution. Remarkably, in vitro release studies revealed that 80 % of PTX was released in 72 h under a reductive environment, whereas only 23 % of PTX was released in 72 h under non-reductive conditions. In addition, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays showed that P(LA-g-mOEG)-b-P(LA-SS-PTX) prodrug micelles retained high anti-tumour activity while polymer carriers were non-toxic up to a tested concentration of 1.0 mg mL–1. These redox-responsive prodrug micelles have tremendous potential for anti-tumour drug delivery.

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Intercalation of Ga3+-salicylidene-amino acid Schiff base complexes into layered double hydroxides: Synthesis, characterization, acid resistant property, in vitro release kinetics and antimicrobial activity

Applied Clay Science ◽

10.1016/j.clay.2013.08.016 ◽

2013 ◽

Vol 83-84 ◽

pp. 182-190 ◽

Cited By ~ 9

Author(s):

Mingzhao Wang ◽

Qin Hu ◽

Dujuan Liang ◽

Ying Li ◽

Sihui Li ◽

...

Keyword(s):

Antimicrobial Activity ◽

Schiff Base ◽

Amino Acid ◽

Release Kinetics ◽

In Vitro Release ◽

Schiff Base Complexes ◽

Double Hydroxides ◽

Amino Acid Schiff Base ◽

Vitro Release

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Anti-inflammatory entrapment in polycaprolactone/silica hybrid material prepared by sol-gel route, characterization, bioactivity and in vitro release behavior

Journal of Applied Biomaterials & Functional Materials ◽

10.5301/jabfm.2012.9256 ◽

2012 ◽

Vol 11 (3) ◽

pp. 172-179 ◽

Cited By ~ 7

Author(s):

Michelina Catauro ◽

Flavia Bollino

Keyword(s):

Hybrid Material ◽

Sol Gel ◽

In Vitro Release ◽

Release Behavior ◽

Anti Inflammatory ◽

Vitro Release ◽

Silica Hybrid

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EFFECT OF DIFFERENT NON IONIC SURFACTANTS ON THE IN-VITRO RELEASE RATE OF A NON STEROIDAL ANTI-INFLAMMATORY DRUG FROM SOME LIPOPHILIC SUPPOSITORY BASES

Zagazig Journal of Pharmaceutical Sciences ◽

10.21608/zjps.2011.161988 ◽

2011 ◽

Vol 20 (1) ◽

pp. 1-8

Author(s):

Sayed Auda ◽

Mahmoud Ahmed ◽

S. Abd El-Rasoul

Keyword(s):

Release Rate ◽

In Vitro Release ◽

Ionic Surfactants ◽

Inflammatory Drug ◽

Anti Inflammatory ◽

Vitro Release

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Enhancement of Anti-Inflammatory Activity of Optimized Niosomal Colchicine Loaded into Jojoba Oil-Based Emulgel Using Response Surface Methodology

Gels ◽

10.3390/gels8010016 ◽

2021 ◽

Vol 8 (1) ◽

pp. 16

Author(s):

Heba S. Elsewedy ◽

Nancy S. Younis ◽

Tamer M. Shehata ◽

Maged E. Mohamed ◽

Wafaa E. Soliman

Keyword(s):

Particle Size ◽

Natural Product ◽

In Vitro Release ◽

Entrapment Efficiency ◽

Inflammatory Activity ◽

Jojoba Oil ◽

Paw Edema ◽

Anti Inflammatory ◽

Vitro Release

Recent progression in investigational studies aiming to integrate natural products and plant oils in developing new dosage forms that would provide optimal therapeutic effect. Therefore, the aim of the present exploration was to inspect the influence of jojoba oil in boosting the anti-inflammatory effect of colchicine natural product. To our knowledge, there is no formulation comprising colchicine and jojoba oil together to form a niosomal emulgel preparation anticipated for topical application. Colchicine is a natural product extracted from Colchicum autumnale that has been evidenced to show respectable anti-inflammatory activity. Owing to its drawbacks and low therapeutic index, it was preferable to be formulated into topical dosage form. The current study inspected colchicine transdermal delivery by developing niosomal preparation as a potential nanocarrier included into emulgel prepared with jojoba oil. Box Behnken design was constructed to develop 17 niosomal emulgel formulations. The optimized colchicine niosomal emulgel was evaluated for its physical characteristics and in vitro release studies. The in vivo anti-inflammatory activity was estimated via carrageenan-induced rat hind paw edema method. The developed colchicine niosomal preparation revealed particle size of 220.7 nm with PDI value 0.22, entrapment efficiency 65.3%. The formulation was found to be stable showing no significant difference in particle size and entrapment efficiency up on storage at 4 °C and 25 °C for 3 months. The optimized colchicine niosomal emulgel exhibited a pH value 6.73, viscosity 4598 cP, and spreadability 38.3 mm. In vitro release study of colchicine from niosomal emulgel formulation was around 52.4% over 6 h. Apparently, the proficient anti-inflammatory activity of colchicine niosomal emulgel was confirmed via carrageenan-induced rat hind paw edema test. Overall, the results recommend the combination of niosomal preparation with jojoba oil-based emulgel that might signify a favorable delivery of anti-inflammatory drug such as colchicine.

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