scholarly journals Immunogenicity of diphtheria toxoid and poly(I:C) loaded cationic liposomes after hollow microneedle-mediated intradermal injection in mice

2018 ◽  
Vol 547 (1-2) ◽  
pp. 250-257 ◽  
Author(s):  
Guangsheng Du ◽  
Mara Leone ◽  
Stefan Romeijn ◽  
Gideon Kersten ◽  
Wim Jiskoot ◽  
...  
Keyword(s):  
Cationic Liposomes ◽  
Intradermal Injection ◽  
Diphtheria Toxoid ◽  
Poly I:C ◽  
Hollow Microneedle

scholarly journals Cationic Liposomes Loaded with a Synthetic Long Peptide and Poly(I:C): a Defined Adjuvanted Vaccine for Induction of Antigen-Specific T Cell Cytotoxicity

2014 ◽  
Vol 17 (1) ◽  
pp. 216-226 ◽  
Author(s):  
Eleni Maria Varypataki ◽  
Koen van der Maaden ◽  
Joke Bouwstra ◽  
Ferry Ossendorp ◽  
Wim Jiskoot
Keyword(s):  
T Cell ◽  
Cationic Liposomes ◽  
Poly I:C ◽  
Cell Cytotoxicity ◽  
Adjuvanted Vaccine ◽  
T Cell Cytotoxicity

CAF05: cationic liposomes that incorporate synthetic cord factor and poly(I:C) induce CTL immunity and reduce tumor burden in mice

2011 ◽  
Vol 61 (6) ◽  
pp. 893-903 ◽  
Author(s):  
Jon Hansen ◽  
Thomas Lindenstrøm ◽  
Julie Lindberg-Levin ◽  
Claus Aagaard ◽  
Peter Andersen ◽  
...  
Keyword(s):  
Cationic Liposomes ◽  
Tumor Burden ◽  
Poly I:C ◽  
Reduce Tumor Burden ◽  
Cord Factor

Reliability and accuracy of intradermal injection by Mantoux technique, hypodermic needle adapter, and hollow microneedle in pigs

2013 ◽  
Vol 4 (2) ◽  
pp. 126-130 ◽  
Author(s):  
James J. Norman ◽  
Jyoti Gupta ◽  
Samirkumar R. Patel ◽  
Sara Park ◽  
Courtney Jarrahian ◽  
...  
Keyword(s):  
Intradermal Injection ◽  
Hypodermic Needle ◽  
Hollow Microneedle

scholarly journals TRANSFER OF DELAYED HYPERSENSITIVITY TO DIPHTHERIA TOXIN IN MAN

1956 ◽  
Vol 104 (3) ◽  
pp. 321-336 ◽  
Author(s):  
H. S. Lawrence ◽  
A. M. Pappenheimer
Keyword(s):  
Transfer Factor ◽  
Peripheral Blood ◽  
Diphtheria Toxin ◽  
Intradermal Injection ◽  
Diphtheria Toxoid ◽  
Delayed Hypersensitivity ◽  
Skin Reactions ◽  
Mild Conditions ◽  
Highly Sensitive ◽  
Simultaneous Transfer

Simultaneous transfer of delayed hypersensitivity to diphtheria toxin and to tuberculin has been accomplished in eight consecutive instances in man using extracts from washed leucocytes taken from the peripheral blood of tuberculin-positive, Schick-negative donors who were highly sensitive (i.e., pseudoreactors) to purified diphtheria toxin and toxoid. The leucocyte extracts used for transfer contained no detectable antitoxin. The recipient subjects were Schick-positive (<0.001 unit antitoxin per ml. serum) and tuberculin-negative at the time of transfer. All the recipients remained Schick-positive for at least 2 weeks following transfer and in every case their serum contained less than 0.001 units antitoxin at the time when they exhibited maximal skin reactivity to toxoid. Evidence is presented which indicates that the transfer factor may be released from leucocyte suspensions under mild conditions in which most of the cells appear to remain morphologically intact. Four adult Schick-positive subjects have been sensitized to diphtheria toxoid by intradermal injection of a few micrograms of purified toxoid in the form of a washed toxoid-antitoxin precipitate. Two of these sensitized individuals showed severe delayed skin reactions specifically directed against diphtheria toxin (or toxoid) at a time when their serum antitoxin level was less than 0.001 units/ml.

scholarly journals Immune and allergic reactions to diphtheria toxin and toxoid in guinea-pigs

1959 ◽  
Vol 57 (2) ◽  
pp. 216-226 ◽  
Author(s):  
D. A. Long
Keyword(s):  
Guinea Pig ◽  
Allergic Reaction ◽  
Guinea Pigs ◽  
Diphtheria Toxin ◽  
High Titre ◽  
Intradermal Injection ◽  
Diphtheria Toxoid ◽  
Allergic Reactions ◽  
Residual Damage

Guinea-pigs immunized with alum-precipitated diphtheria toxoid (APT) become hypersensitive to diphtheria toxin and toxid. This hypersensitivity is probably due to a mixture of immediate (Arthus-type) reactions and delayed (tuberculin-type) reactions, the former increasing as the level of circulating precipitating antitoxin rose and tending to mask the latter. In a hyperimmune guinea-pig the residual damage following the intradermal injection of toxin is due, at least in part, to hypersensitivity to toxin; toxicity probably contributes relatively little to the extent of the lesion in animals with a high titre of antitoxin.The technical difficulties of proving the presence of a delayed allergic reaction in animals with an early allergic reaction are discussed.I am grateful to Dr C. G. Pope, who has been closely associated with this work, not only for providing highly purified materials, but also for his advice.

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