Preparation, characterization, and evaluation of celecoxib eutectic mixtures with adipic acid/saccharin for improvement of wettability and dissolution rate

2019 ◽  
Vol 554 ◽  
pp. 61-71 ◽  
Author(s):  
Sang-Min Hyun ◽  
Benjamin Joon Lee ◽  
Sharif Md Abuzar ◽  
Soohun Lee ◽  
Yechan Joo ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Adipic Acid ◽  
Eutectic Mixtures

Experimental Study on Reactivity of Limestone in FGD System

2014 ◽  
Vol 875-877 ◽  
pp. 1702-1706 ◽  
Author(s):  
Wan Peng Zhang ◽  
Mei Yan Wang ◽  
Xiu Qin Ma ◽  
Chao Huang ◽  
Fang Chen ◽  
...  
Keyword(s):  
Organic Acid ◽  
Dissolution Rate ◽  
Adipic Acid ◽  
Inorganic Salt ◽  
Ph Value ◽  
Limestone Dissolution ◽  
Acid Titration ◽  
High Dissolution Rate ◽  
Negative Role ◽  
Short Time

The limestone collected from the Ji county of Tianjin was investigated in this study. The characterization of the limestone dissolution in wet FGD system is carried out by sulfuric acid titration. The results indicate that A lower PH value is benefit for the limestone dissolution, which causes high dissolution rate within short time. Smaller particle size results in higher dissolution rate. The addition of inorganic salt and organic acid significantly affect the limestone dissolution. The limestone dissolution rate increases with the increase of organic acid concentration. In all the inorganic salt, it is obvious that Na+ has an positive effect while CI- plays a negative role on the limestone dissolution. However, the addition of composite additive of adipic acid plus MgO to the limestone slurry is greatly better than using the adipic acid or MgO only.

Solubility Enhancement of Poorly Soluble Drug Simvastatin by Solid Dispersion Technique

2016 ◽  
Vol 2 (2) ◽  
pp. 91-95
Author(s):  
Neelima Rani T ◽  
Pavani A ◽  
Sobhita Rani P ◽  
Srilakshmi N
Keyword(s):  
Dissolution Rate ◽  
Drug Carrier ◽  
Solid Dispersions ◽  
Aqueous Solubility ◽  
Onset Of Action ◽  
Kneading Method ◽  
Wetting Property ◽  
Poorly Soluble ◽  
Dispersion Technique ◽  
Low Solubility

This study aims to formulate solid dispersions (SDs) of Simvastatin (SIM) to improve the aqueous solubility, dissolution rate and to facilitate faster onset of action. Simvastatin is a BCS class II drug having low solubility & therefore low oral bioavailability. In the present study, SDs of simvastatin different drug-carrier ratios were prepared by kneading method. The results showed that simvastatin solubility & dissolution rate enhanced with polymer SSG in the ratio 1:7 due to increase in wetting property or possibly may be due to change in crystallinity of the drug.

Dissolution Rate of Copper in Lead and Aluminum Melts

1994 ◽  
Vol 80 (4) ◽  
pp. 294-299
Author(s):  
Katsumi MORI ◽  
Toshiro KITAHARA ◽  
Kunihiko NAKASHIMA
Keyword(s):  
Dissolution Rate
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