Polyelectrolyte–surfactant–complex nanoparticles as a delivery platform for poorly soluble drugs: A case study of ibuprofen loaded cetylpyridinium-alginate system

2020 ◽  
Vol 580 ◽  
pp. 119199 ◽  
Author(s):  
Janja Mirtič ◽  
Amrit Paudel ◽  
Peter Laggner ◽  
Samo Hudoklin ◽  
Mateja Erdani Kreft ◽  
...  
Keyword(s):  
Poorly Soluble Drugs ◽  
Surfactant Complex ◽  
Poorly Soluble ◽  
Delivery Platform

Sampling only ten microliters of whole blood for the quantification of poorly soluble drugs: Itraconazole as case study

2017 ◽  
Vol 1479 ◽  
pp. 161-168 ◽  
Author(s):  
Justine Thiry ◽  
Brigitte Evrard ◽  
Gwenaël Nys ◽  
Marianne Fillet ◽  
Miranda G.M. Kok
Keyword(s):  
Whole Blood ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

Physicochemical Properties of Solid Phospholipid Particles as a Drug Delivery Platform for Improving Oral Absorption of Poorly Soluble Drugs

2016 ◽  
Vol 34 (1) ◽  
pp. 208-216 ◽  
Author(s):  
Kohsaku Kawakami ◽  
Aoi Miyazaki ◽  
Mayuko Fukushima ◽  
Keiko Sato ◽  
Yuko Yamamura ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Oral Absorption ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble ◽  
Delivery Platform

Property prediction and pharmacokinetic evaluation of mixed stoichiometry cocrystals of zafirlukast, a drug delivery case study

CrystEngComm ◽  
2018 ◽  
Vol 20 (10) ◽  
pp. 1346-1351 ◽  
Author(s):  
Philip A. Corner ◽  
David J. Berry ◽  
James F. McCabe ◽  
Rafael Barbas ◽  
Rafel Prohens ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Poorly Soluble Drugs ◽  
Property Prediction ◽  
Poorly Soluble ◽  
Pharmacokinetic Evaluation

Cocrystals have been identified as a method for ensuring the delivery of poorly soluble drugs.

Technological Advancements in Oral Films

2019 ◽  
Vol 9 (01) ◽  
pp. 15-20
Author(s):  
B Pandey ◽  
A B Khan
Keyword(s):  
3D Printing ◽  
Historical Background ◽  
Poorly Soluble Drugs ◽  
Modern Approach ◽  
Poorly Soluble ◽  
Critical Process Parameters ◽  
Biopharmaceutical Properties ◽  
Oral Films ◽  
Hot Melt ◽  
Modern Technologies

The aim of the review was to explore the necessity, advantages and different techniques of oral films for enhancing solubility of poorly soluble drugs with an emphasis on the newer, state-of the art technologies, such as 3D printing and hot-melt extrusion (HME). The historical background of oral films is presented along with the regularly used techniques. The modern approach of quality-by-design (QbD) is unravelled, identifying appropriate critical process parameters (CPP) and applied to oral films. A section is devoted modern technologies such as 3D printing and HME of oral films. Oral films are innovative formulations by which poorly soluble drugs have been founds to give positive results in enhancing their solubility and dissolution characteristics. With modern sophisticated techniques, precise mass production of oral films has been given a thrust. Oral films have better patient compliance, improved biopharmaceutical properties, improved efficacy, and better safety. By applying QbD and implementation of modern technologies the newer generation of oral films are yielding promising results

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