scholarly journals Microdosing Framework for Absolute Bioavailability Assessment of Poorly Soluble Drugs: A Case Study on Cold‐Labeled Venetoclax, from Chemistry to the Clinic

2021 ◽  
Author(s):  
Amr Alaarg ◽  
Rajeev Menon ◽  
David Rizzo ◽  
Yemin Liu ◽  
Jeffrey Bien ◽  
...  
Keyword(s):  
Absolute Bioavailability ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

Sampling only ten microliters of whole blood for the quantification of poorly soluble drugs: Itraconazole as case study

2017 ◽  
Vol 1479 ◽  
pp. 161-168 ◽  
Author(s):  
Justine Thiry ◽  
Brigitte Evrard ◽  
Gwenaël Nys ◽  
Marianne Fillet ◽  
Miranda G.M. Kok
Keyword(s):  
Whole Blood ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

Use of Spray Flash Evaporation (SFE) technology to improve dissolution of poorly soluble drugs: Case study on furosemide nanocrystals

2020 ◽  
Vol 589 ◽  
pp. 119827 ◽  
Author(s):  
Jean-Baptiste Coty ◽  
Cédric Martin ◽  
Isabella Telò ◽  
Denis Spitzer
Keyword(s):  
Poorly Soluble Drugs ◽  
Flash Evaporation ◽  
Poorly Soluble

Polyelectrolyte–surfactant–complex nanoparticles as a delivery platform for poorly soluble drugs: A case study of ibuprofen loaded cetylpyridinium-alginate system

2020 ◽  
Vol 580 ◽  
pp. 119199 ◽  
Author(s):  
Janja Mirtič ◽  
Amrit Paudel ◽  
Peter Laggner ◽  
Samo Hudoklin ◽  
Mateja Erdani Kreft ◽  
...  
Keyword(s):  
Poorly Soluble Drugs ◽  
Surfactant Complex ◽  
Poorly Soluble ◽  
Delivery Platform

Property prediction and pharmacokinetic evaluation of mixed stoichiometry cocrystals of zafirlukast, a drug delivery case study

CrystEngComm ◽  
2018 ◽  
Vol 20 (10) ◽  
pp. 1346-1351 ◽  
Author(s):  
Philip A. Corner ◽  
David J. Berry ◽  
James F. McCabe ◽  
Rafael Barbas ◽  
Rafel Prohens ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Poorly Soluble Drugs ◽  
Property Prediction ◽  
Poorly Soluble ◽  
Pharmacokinetic Evaluation

Cocrystals have been identified as a method for ensuring the delivery of poorly soluble drugs.

Technological Advancements in Oral Films

2019 ◽  
Vol 9 (01) ◽  
pp. 15-20
Author(s):  
B Pandey ◽  
A B Khan
Keyword(s):  
3D Printing ◽  
Historical Background ◽  
Poorly Soluble Drugs ◽  
Modern Approach ◽  
Poorly Soluble ◽  
Critical Process Parameters ◽  
Biopharmaceutical Properties ◽  
Oral Films ◽  
Hot Melt ◽  
Modern Technologies

The aim of the review was to explore the necessity, advantages and different techniques of oral films for enhancing solubility of poorly soluble drugs with an emphasis on the newer, state-of the art technologies, such as 3D printing and hot-melt extrusion (HME). The historical background of oral films is presented along with the regularly used techniques. The modern approach of quality-by-design (QbD) is unravelled, identifying appropriate critical process parameters (CPP) and applied to oral films. A section is devoted modern technologies such as 3D printing and HME of oral films. Oral films are innovative formulations by which poorly soluble drugs have been founds to give positive results in enhancing their solubility and dissolution characteristics. With modern sophisticated techniques, precise mass production of oral films has been given a thrust. Oral films have better patient compliance, improved biopharmaceutical properties, improved efficacy, and better safety. By applying QbD and implementation of modern technologies the newer generation of oral films are yielding promising results

Self-microemulsion Technology for Water-insoluble Drug Delivery

2019 ◽  
Vol 15 (6) ◽  
pp. 576-588 ◽  
Author(s):  
Beibei Yan ◽  
Yu Gu ◽  
Juan Zhao ◽  
Yangyang Liu ◽  
Lulu Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Aqueous Solubility ◽  
Delivery Systems ◽  
Poorly Soluble Drugs ◽  
New Chemical Entities ◽  
Poorly Soluble ◽  
Water Insoluble Drug ◽  
Semi Solid ◽  
Solidification Technology

: According to the drug discovery, approximately 40% of the new chemical entities show poor bioavailability due to their low aqueous solubility. In order to increase the solubility of the drugs, self-micro emulsifying drug delivery systems (SMEDDS) are considered as an ideal technology for enhancing the permeability of poorly soluble drugs in GI membranes. The SMEDDS are also generally used to enhance the oral bioavailability of the hydrophobic drugs. At present, most of the self-microemulsion drugs are liquid dosage forms, which could cause some disadvantages, such as the low bioavailability of the traditional liquid SMEDDS. Therefore, solid self-micro emulsifying drug delivery systems (S-SMEDDS) have emerged widely in recent years, which were prepared by solidifying a semi-solid or liquid self-emulsifying (SE) ingredient into a powder in order to improve stability, treatment and patient compliance. The article gives a comprehensive introduction of the study of SMEDDS which could effectively tackle the problem of the water-insoluble drug, especially the development of solidification technology of SMEDDS. Finally, the present challenges and the prospects in this field were also discussed.

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