Can standard deviation of overnight pulse oximetry be used to screen childhood obstructive sleep apnea

Author(s):  
Siriporn Warapongmanupong ◽  
Aroonwan Preutthipan
Author(s):  
Kimimasa Saito ◽  
Yosuke Okada ◽  
Keiichi Torimoto ◽  
Yoko Takamatsu ◽  
Yoshiya Tanaka

Abstract Purpose Glycemic variability (GV) and hypoglycemia during nighttime are presumed to be associated with fatal bradycardia. The aim of this prospective study was to evaluate blood glucose dynamics during sleep in patients with obstructive sleep apnea syndrome (OSA) and normal glucose tolerance. Methods Patients with OSA and no diabetes who underwent type 1 overnight polysomnography from December 2018 to May 2020 participated in this study. GV was evaluated in all participants for 14 days using a flash glucose monitoring device. Correlations were examined between GV indexes and indexes related to sleep breathing disorders, the effects of treatment with continuous positive airway pressure (CPAP) on these GV indexes, and the characteristics of glucose dynamics in different OSA subtypes classified by sleep stage. Results Among 42 patients with OSA and no diabetes, the standard deviation of GV during sleep correlated significantly with sleep time spent with oxygen saturation <90% (r=0.591, p=0.008). High blood glucose index during sleep correlated significantly with stage N1% (r=0.491, p=0.032) and negatively with stage N2% (r=−0.479, p=0.038). High blood glucose index correlated significantly with sleep time spent with oxygen saturation <90% (r=0.640, p=0.003). The rapid eye movement–related OSA group had a higher incidence of hypoglycemia. One-week with CPAP treatment significantly improved GV during sleep, standard deviation of GV (from 12.1 to 9.0 mg/dL, p<0.001), and high blood glucose index (from 0.7 to 0.4, p=0.006). Conclusions To evaluate GV during sleep in patients with OSA may be useful for clinical risk management. CPAP treatment for 1 week may have an improving GV and high blood glucose index. Clinical trial registration UMIN000038489 2019/11/04, UMIN 000025433 2016/12/27


2019 ◽  
Vol 40 (1) ◽  
pp. 62-70 ◽  
Author(s):  
Huei-Chen Lin ◽  
Chien-Ling Su ◽  
Jun-Hui Ong ◽  
kun-ling Tsai ◽  
Yu-Wen Chen ◽  
...  

2014 ◽  
Vol 21 (3) ◽  
pp. 171-175 ◽  
Author(s):  
Adrienne S Scott ◽  
Marcel A Baltzan ◽  
Norman Wolkove

Nocturnal hypoxemia and obstructive sleep apnea (OSA) are common comorbidities in patients with chronic obstructive pulmonary disease (COPD). The authors sought to develop a strategy to interpret nocturnal pulse oximetry and assess its capacity for detection of OSA in patients with stage 3 to stage 4 COPD. A review of consecutive patients with COPD who were clinically prescribed oximetry and polysomnography was conducted. OSA was diagnosed if the polysomnographic apnea-hypopnea index was >15 events/h. Comprehensive criteria were developed for interpretation of pulse oximetry tracings through iterative validation and interscorer concordance of ≥80%. Criteria consisted of visually identified desaturation ‘events’ (sustained desaturation ≥4%, 1 h time scale), ‘patterns’ (≥3 similar desaturation/saturation cycles, 15 min time scale) and the automated oxygen desaturation index. The area under the curve (AUC), sensitivity, specificity and accuracy were calculated. Of 59 patients (27 male), 31 had OSA (53%). The mean forced expiratory volume in 1 s was 46% of predicted (range 21% to 74% of predicted) and 52% of patients were on long-term oxygen therapy. Among 59 patients, 35 were correctly identified as having OSA or not having OSA, corresponding to an accuracy of 59%, with a sensitivity and specificity of 59% and 60%, respectively. The AUC was 0.57 (95% CI 0.55 to 0.59). Using software-computed desaturation events (hypoxemia ≥4% for ≥10 s) indexed at ≥15 events/h of sleep as diagnostic criteria, sensitivity was 60%, specificity was 63% and the AUC was 0.64 (95%CI 0.62 to 0.66). No single criterion demonstrated important diagnostic utility. Pulse oximetry tracing interpretation had a modest diagnostic value in identifying OSA in patients with moderate to severe COPD.


2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Jose A. Peña-Zarza ◽  
Borja Osona-Rodriguez de Torres ◽  
Jose Antonio Gil-Sanchez ◽  
Joan Figuerola-Mulet

Objective. To assess the screening tools in snoring patients.Material and Methods. A retrospective review of data was conducted from children between 2 and 15 years old who were referred on suspicion of obstructive sleep apnea-hypopnea (OSAH) between June 2008 and June 2011. We excluded patients with significant comorbidities. Pediatric Sleep Questionnaire (PSQ), physical exam (PE), and pulse-oximetry data were collected and correlated with the results of the nightly polygraph at home.Results. We selected 98 patients. The 22-item version of the PSQ had sensitivity of 96% and specificity of 36.8%. The overall value of the clinic predictor of OSAH (PSQ and PE together) exhibited an increased specificity 57.6% with 94.6% of sensitivity. The nocturnal home oximetry method used alone was very specific, 92.1%, but had a lower sensitivity, 77.1%. The set of clinical assessment tools used together with pulse-oximetry screening provided excellent specificity 98.1% and a positive predictive value 94.1% globally. The performance of this screening tool is related with the severity of OSAH and accuracy is better in moderate and severe cases.Conclusion. The combination of clinical assessment and pulse-oximetry screening can provide a sufficient diagnostic approach for pediatric patients with suspected OSAH at least in moderate and severe cases.


2014 ◽  
Vol 36 (8) ◽  
pp. 1074-1080 ◽  
Author(s):  
Gastón Schlotthauer ◽  
Leandro E. Di Persia ◽  
Luis D. Larrateguy ◽  
Diego H. Milone

2020 ◽  
Vol 3 (2) ◽  
pp. 58-62
Author(s):  
Dhia Maulidya Mirwan ◽  
Eveline Margo

LATAR BELAKANGObstructive sleep apnea (OSA) merupakan kondisi umum pada saat tidur ditandai dengan mendengkur. Di Indonesia, data prevalensi OSA masih sangat sedikit, namun pada penelitian di Jakarta tahun 2013 didapatkan 70% pada laki-laki dengan rentang usia 35-73 tahun menderita OSA. Kejadian OSA dapat mengganggu sistem pernapasan serta fungsi kognitif seseorang. Hal ini ditandai dengan hipoksia yang dapat menimbulkan fase arousal pada risiko OSA. Namun, pada beberapa penelitian ditemukan tidak terdapatnya hubungan kadar saturasi oksigen pada penderita OSA sehingga membuat peneliti hendak menilai kembali. Tujuan penelitian ini untuk mengetahui hubungan saturasi oksigen dengan risiko terjadinya OSA pada pria usia 30-60 tahun. METODEPenelitian ini menggunakan studi observasional analitik dengan desain studi potong lintang (cross-sectional) yang dilakukan pada bulan April hingga Juni 2019. Penentuan sampel menggunakan teknik random sampling, pada 64 orang pria usia 30-60 tahun. Data dikumpulkan dengan cara wawancara menggunakan kuesioner Berlin untuk mengetahui ada tidaknya OSA dan dilakukan pengukuran saturasi oksigen menggunakan pulse oximetry. Analisis hipotesis dilakukan dengan uji Chi-square dengan tingkat kemaknaan yang digunakan p < 0.05. HASILDidapatkan responden 64 orang dengan 42 orang (65.6%) memiliki risiko tinggi OSA, dan 22 orang (34.4%) lainnya memiliki risiko rendah OSA, sedangkan pada uji Chi-square untuk melihat hubungan kadar saturasi oksigen dengan resiko terjadinya OSA didapatkan p=1.000. KESIMPULANPenelitian ini menunjukan tidak ada hubungan bermakna antara kadar saturasi oksigen dengan risiko terjadinya OSA.


Sign in / Sign up

Export Citation Format

Share Document