Differences in the neurocognitive development of premature and full-term infants in the first year of life

2016 ◽  
Vol 108 ◽  
pp. 143
Author(s):  
Sergey Kiselev ◽  
Olga Lvova ◽  
Ekaterina Suleymanova
Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2412
Author(s):  
Sonia González ◽  
Marta Selma-Royo ◽  
Silvia Arboleya ◽  
Cecilia Martínez-Costa ◽  
Gonzalo Solís ◽  
...  

The early life gut microbiota has been reported to be involved in neonatal weight gain and later infant growth. Therefore, this early microbiota may constitute a target for the promotion of healthy neonatal growth and development with potential consequences for later life. Unfortunately, we are still far from understanding the association between neonatal microbiota and weight gain and growth. In this context, we evaluated the relationship between early microbiota and weight in a cohort of full-term infants. The absolute levels of specific fecal microorganisms were determined in 88 vaginally delivered and 36 C-section-delivered full-term newborns at 1 month of age and their growth up to 12 months of age. We observed statistically significant associations between the levels of some early life gut microbes and infant weight gain during the first year of life. Classifying the infants into tertiles according to their Staphylococcus levels at 1 month of age allowed us to observe a significantly lower weight at 12 months of life in the C-section-delivered infants from the highest tertile. Univariate and multivariate models pointed out associations between the levels of some fecal microorganisms at 1 month of age and weight gain at 6 and 12 months. Interestingly, these associations were different in vaginally and C-section-delivered babies. A significant direct association between Staphylococcus and weight gain at 1 month of life was observed in vaginally delivered babies, whereas in C-section-delivered infants, lower Bacteroides levels at 1 month were associated with higher later weight gain (at 6 and 12 months). Our results indicate an association between the gut microbiota and weight gain in early life and highlight potential microbial predictors for later weight gain.


2018 ◽  
Author(s):  
Alex Grier ◽  
Andrew McDavid ◽  
Bokai Wang ◽  
Xing Qiu ◽  
James Java ◽  
...  

ABSTRACTBackground: Postnatal development of the microbiota in early life influences immunity, metabolism, neurodevelopment and long-term infant health. Microbiome development occurs at multiple body sites, each with distinct community compositions and functions. Associations between microbiota at multiple sites represent an unexplored influence on the infant microbiome. Here, we examined co-occurrence patterns of gut and respiratory microbiota in pre- and full-term infants over the first year of life, a period critical to neonatal development and risk of respiratory diseases.Results: Gut and respiratory microbiota collected as longitudinal rectal, throat and nasal samples from 38 pre-term and 44 full-term infants were first clustered into community state types (CSTs) on the basis of their composition. Multiple methods were used to relate the occurrence of CSTs to several measures of infant maturity, including gestational age (GA) at birth, week of life (WOL), and post menstrual age (PMA: equal to GA plus WOL). Manifestation of CSTs followed one of three patterns with respect to infant maturity. First, chronological: independent of infant maturity (GA) at birth, and strongly associated with post-natal age (WOL). Second, idiosyncratic: primarily dependent on maturity (GA) at birth, with persistent differences in CST occurrence between pre- and full-term infants through the first year of life. Third, convergent: CSTs appear earlier in infants with greater maturity (GA) at birth, but after a sufficient post-natal interval their occurrence in pre-term infants reaches parity with full-term infants. The composition of CSTs was highly dissimilar between different body sites, but the CST of any one body site was highly predictive of the CSTs at other body sites. There were significant associations between the abundance of individual taxa at each body site and the CSTs of the other body sites, which persisted after stringent control for the non-linear effects of infant maturity. Significant canonical correlations exist between the microbiota composition at each pair of body sites, with the strongest correlations between more proximal locations.Conclusion: Cross-body site associations of developing infant microbiota suggest the importance of research and clinical practices that focus on dynamic interactions between multiple microbial communities to elucidate and promote systemic microbiota development.


2019 ◽  
Vol 61 (10) ◽  
pp. 967-977 ◽  
Author(s):  
Nadia Cristina Valentini ◽  
Keila Ruttnig Guidony Pereira ◽  
Eloá Maria dos Santos Chiquetti ◽  
Cibelle Kayenne Martins Roberto Formiga ◽  
Maria Beatriz Martins Linhares

2021 ◽  
Vol 62 ◽  
pp. 101520
Author(s):  
Zsuzsanna Varga ◽  
Anett Ragó ◽  
Ferenc Honbolygó ◽  
Valéria Csépe

Author(s):  
Timo I. Takala ◽  
Enni Mäkelä ◽  
Pauli Suominen ◽  
Jaakko Matomäki ◽  
Helena Lapinleimu ◽  
...  

PEDIATRICS ◽  
1955 ◽  
Vol 15 (2) ◽  
pp. 169-179
Author(s):  
Mary R. Richards ◽  
Katharine K. Merritt ◽  
Mary H. Samuels ◽  
Alfred G. Langmann

The frequency of cardiac murmurs in early infancy has been studied in a large series of unselected infants. In the immediate postnatal examination, a murmur was heard in 1.7 per cent. With repeated examinations, however, at 6 and at 12 months of age, the proportion of infants in whom a cardiac murmur was heard at some time rose to 7.0 per cent of 5,017 full-term singlebirth infants and to 9.9 per cent of 364 premature single-birth infants. Non-white infants had a significantly higher prevalence of murmurs than did white infants at both the 6 and 12 month examinations. Of the 71 full-term infants who had murmurs at the birth examination and were re-examined at both 6 and 12 months, 49 (69 per cent) had no murmurs at either of the later examinations. Of the 150 full-term infants who had murmurs heard for the first time at 6 months and were re-examined at 12 months, 90 (60 per cent) had no murmur at the 12-month examination. Of the total number of 353 murmurs heard in full-term infants, 166 were ultimately interpreted to be functional, and 25 to be organic murmurs. The remaining 162 were inconstantly present, and were probably all functional murmurs. In our experience, a murmur heard at birth carries a 1:12 probability of congenital heart disease; if it is again heard at 6 months, this chance is 1:3; and if the murmur persists to 12 months, the chance is 3:5 that congenital heart disease is present. When a murmur is first heard at 6 months, and persists until 12 months, the probability of congenital heart disease is 1:7; and when a murmur is first heard at 12 months, the probability falls to 1:50. Premature infants were found to be similar to full-term infants in all respects, insofar as their small numbers made comparisons possible. Finally, the relative rarity of cardiac murmurs in the newborn period has been demonstrated once more.


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