ssDefault mode network connectivity and attention-deficit/hyperactivity disorder in adolescence: Associations with delay aversion and temporal discounting, but not mind wandering

Author(s):  
M. John Broulidakis ◽  
Dennis Golm ◽  
Samuele Cortese ◽  
Graeme Fairchild ◽  
Edmund Sonuga-Barke
2020 ◽  
pp. 008124632096435
Author(s):  
Ramatladi Meriam Mphahlele ◽  
Basil Joseph Pillay ◽  
Anneke Meyer

This study considered whether children with attention-deficit hyperactivity disorder displayed a stronger preference for smaller, more immediate rewards over larger, but delayed rewards (delay aversion) when compared to typically developing controls and, furthermore, whether age and gender influenced their preference in any way. Children, between 6 and 15 years of age, living in Limpopo province of South Africa, participated in the study. Two hundred sixteen children in total (108 with attention-deficit hyperactivity disorder and 108 matched controls without attention-deficit hyperactivity disorder symptoms) were assessed, on a task of delay aversion. The Two Choice Impulsivity Paradigm, which assesses immediate and delayed responses, was administered to both the attention-deficit hyperactivity disorder and control groups. The performance of both groups was compared on the Two Choice Impulsivity Paradigm, and the scores were analysed as a function of gender and age. The attention-deficit hyperactivity disorder group chose significantly more immediate, smaller responses than the neurotypical control group, which preferred significantly more delayed but larger responses. Gender and age did not affect the response choices for both immediate and delayed measurements. Children with attention-deficit hyperactivity disorder show a greater need for more immediate gratification, even if the reward is smaller, than the neurotypical control group who could delay gratification to receive a larger reward. Gender and age did not influence their preferences.


2013 ◽  
Vol 122 (2) ◽  
pp. 566-572 ◽  
Author(s):  
Gregor Wilbertz ◽  
Amalie Trueg ◽  
Edmund J. S. Sonuga-Barke ◽  
Jens Blechert ◽  
Alexandra Philipsen ◽  
...  

2019 ◽  
Vol 3 (1) ◽  
pp. 195-216 ◽  
Author(s):  
Nina de Lacy ◽  
Vince D. Calhoun

The analysis of time-varying connectivity by using functional MRI has gained momentum given its ability to complement traditional static methods by capturing additional patterns of variation in human brain function. Attention deficit hyperactivity disorder (ADHD) is a complex, common developmental neuropsychiatric disorder associated with heterogeneous connectivity differences that are challenging to disambiguate. However, dynamic connectivity has not been examined in ADHD, and surprisingly few whole-brain analyses of static functional network connectivity (FNC) using independent component analysis (ICA) exist. We present the first analyses of time-varying connectivity and whole-brain FNC using ICA in ADHD, introducing a novel framework for comparing local and global dynamic connectivity in a 44-network model. We demonstrate that dynamic connectivity analysis captures robust motifs associated with group effects consequent on the diagnosis of ADHD, implicating increased global dynamic range, but reduced fluidity and range localized to the default mode network system. These differentiate ADHD from other major neuropsychiatric disorders of development. In contrast, static FNC based on a whole-brain ICA decomposition revealed solely age effects, without evidence of group differences. Our analysis advances current methods in time-varying connectivity analysis, providing a structured example of integrating static and dynamic connectivity analysis to further investigation into functional brain differences during development.


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