Electromagnetic Real-Time Tumor Position Monitoring and Dynamic Multileaf Collimator Tracking Using a Siemens 160 MLC: Geometric and Dosimetric Accuracy of an Integrated System

This study developed and field tested an automated weed mapping and variable-rate herbicide spraying (VRHS) system for row crops. Weed detection was performed through a machine vision sub-system that used a custom threshold segmentation method, an improved particle swarm optimum (IPSO) algorithm, capable of segmenting the field images. The VRHS system also used a lateral histogram-based algorithm for fast extraction of weed maps. This was the basis for determining real-time herbicide application rates. The central processor of the VRHS system had high logic operation capacity, compared to the conventional controller-based systems. Custom developed monitoring system allowed real-time visualization of the spraying system functionalities. Integrated system performance was then evaluated through field experiments. The IPSO successfully segmented weeds within corn crop at seedling growth stage and reduced segmentation error rates to 0.1% from 7.1% of traditional particle swarm optimization algorithm. IPSO processing speed was 0.026 s/frame. The weed detection to chemical actuation response time of integrated system was 1.562 s. Overall, VRHS system met the real-time data processing and actuation requirements for its use in practical weed management applications.

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Assembly of Conducting Polymer and Biohydrogel for the Release and Real-Time Monitoring of Vitamin K3

Gels ◽

10.3390/gels4040086 ◽

2018 ◽

Vol 4 (4) ◽

pp. 86 ◽

Cited By ~ 2

Author(s):

Brenda Molina ◽

Eva Domínguez ◽

Elaine Armelin ◽

Carlos Alemán

Keyword(s):

Real Time ◽

Differential Pulse ◽

Integrated System ◽

Dual Function ◽

Therapeutic Approaches ◽

Vitamin K3 ◽

Flexible Electrode ◽

Anodic Synthesis

In this work, we report the design and fabrication of a dual-function integrated system to monitor, in real time, the release of previously loaded 2-methyl-1,4-naphthoquinone (MeNQ), also named vitamin K3. The newly developed system consists of poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles, which were embedded into a poly-γ-glutamic acid (γ-PGA) biohydrogel during the gelling reaction between the biopolymer chains and the cross-linker, cystamine. After this, agglomerates of PEDOT nanoparticles homogeneously dispersed inside the biohydrogel were used as polymerization nuclei for the in situ anodic synthesis of poly(hydroxymethyl-3,4-ethylenedioxythiophene) in aqueous solution. After characterization of the resulting flexible electrode composites, their ability to load and release MeNQ was proven and monitored. Specifically, loaded MeNQ molecules, which organized in shells around PEDOT nanoparticles agglomerates when the drug was simply added to the initial gelling solution, were progressively released to a physiological medium. The latter process was successfully monitored using an electrode composite through differential pulse voltammetry. The fabrication of electroactive flexible biohydrogels for real-time release monitoring opens new opportunities for theranostic therapeutic approaches.

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