Survival Analysis of FIGO Stage IIIC Endometrial Cancer Patients

2010 ◽  
Vol 78 (3) ◽  
pp. S145 ◽  
Author(s):  
A.P. Brown ◽  
D.K. Gaffney ◽  
M.K. Dodson ◽  
A.P. Soisson ◽  
W.T. Sause
Keyword(s):  
Endometrial Cancer ◽  
Survival Analysis ◽  
Cancer Patients ◽  
Figo Stage ◽  
Stage Iiic

Survival Analysis of Cancer Patients With FIGO Stage IIIA Endometrial Cancer

2015 ◽  
Vol 38 (3) ◽  
pp. 283-288 ◽  
Author(s):  
Marija M. Lum ◽  
Thomas W. Belnap ◽  
Jonathan Frandsen ◽  
Aaron P. Brown ◽  
William T. Sause ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Survival Analysis ◽  
Cancer Patients ◽  
Figo Stage ◽  
Stage Iiia

Analysis of FIGO Stage IIIc Endometrial Cancer Patients

2001 ◽  
Vol 81 (2) ◽  
pp. 273-278 ◽  
Author(s):  
D.Scott McMeekin ◽  
Daphne Lashbrook ◽  
Michael Gold ◽  
Gary Johnson ◽  
Joan L. Walker ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Patients ◽  
Figo Stage ◽  
Stage Iiic

scholarly journals Survival in endometrial cancer in relation to minimally invasive surgery or open surgery – a Swedish Gynecologic Cancer Group (SweGCG) study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Christer Borgfeldt ◽  
Erik Holmberg ◽  
Janusz Marcickiewicz ◽  
Karin Stålberg ◽  
Bengt Tholander ◽  
...  
Keyword(s):  
Risk Factors ◽  
Overall Survival ◽  
Endometrial Cancer ◽  
Minimally Invasive ◽  
Cancer Patients ◽  
Surgical Approach ◽  
Open Surgery ◽  
Gynecologic Cancer ◽  
Multivariable Analysis ◽  
Figo Stage

Abstract Background The aim of this study was to analyze overall survival in endometrial cancer patients’ FIGO stages I-III in relation to surgical approach; minimally invasive (MIS) or open surgery (laparotomy). Methods A population-based retrospective study of 7275 endometrial cancer patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed from 2010 to 2018. Cox proportional hazard models were used in univariable and multivariable survival analyses. Results In univariable analysis open surgery was associated with worse overall survival compared with MIS hazard ratio, HR, 1.39 (95% CI 1.18–1.63) while in the multivariable analysis, surgical approach (MIS vs open surgery) was not associated with overall survival after adjustment for known risk factors (HR 1.12, 95% CI 0.95–1.32). Higher FIGO stage, non-endometrioid histology, non-diploid tumors, lymphovascular space invasion and increasing age were independent risk factors for overall survival. Conclusion The minimal invasive or open surgical approach did not show any impact on survival for patients with endometrial cancer stages I-III when known prognostic risk factors were included in the multivariable analyses.

Significance of morphometric, DNA cytometric features, and other prognostic markers on survival of endometrial cancer patients in northern Norway

2002 ◽  
Vol 12 (1) ◽  
pp. 49-56 ◽  
Author(s):  
A Ørbo ◽  
M Rydningen ◽  
B Straume ◽  
S Lysne
Keyword(s):  
Endometrial Cancer ◽  
Cancer Patients ◽  
Vascular Invasion ◽  
Prognostic Markers ◽  
Dna Ploidy ◽  
Prognostic Significance ◽  
Figo Stage ◽  
Stage I ◽  
Northern Norway

Abstract.Ørbo A, Rydningen M, Straume B, Lysne S. Significance of morphometric, DNA cytometric features, and other prognostic markers on survival of endometrial cancer patients in northern Norway.The objective of this study was to evaluate the prognostic value of nuclear morphometric features and DNA ploidy by flow cytometry next to depth of myometrial invasion and vascular invasion in endometrial cancer of all FIGO stages.A total of 123 women (103 FIGO stage I, eight stage II, and 12 stage III and IV) from northern Norway were studied. The follow-up period was between 7 and 19 years. The median age of patients was 62 years. The primary surgery was performed in the University Hospital of Tromsø or in the seven different reference hospitals in the northern part of Norway after an endometrial cancer diagnosis. The histologic, morphometric, flowcytometric and immunohistochemical investigations were based on archival paraffin-embedded material. The information regarding the follow-up data and clinical information were obtained from the medical records.Thirteen (10.6%) patients from the entire group (all stages) but only three (2.7%) of the FIGO stage I and II patients died from locally recurrent or metastatic disease. FIGO substage (P = 0.0006; odds ratio [OR] = 16.44, 95% confidence interval [CI] = 3.36–80.45), vascular invasion (P = 0.01, OR = 6.42, CI = 1.57–26.34) and nuclear size (P = 0.025, 0 R = 1.3, CI = 1.05–1.61) were independently correlated with recurrence in a multivariate analysis but histologic grade and DNA ploidy were not. Vascular invasion was poorly reproducible both between and within the same observer, however.In this retrospective study of all stages of endometrial carcinoma with long follow-up periods the primary tumor characteristics nuclear perimeter and FIGO stage were of prognostic significance in addition to the poorly reproducible vessel invasion.

scholarly journals An Immune-Related Long Noncoding RNA Signature as a Prognostic Biomarker for Human Endometrial Cancer

2020 ◽  
Author(s):  
Ziwei Wang ◽  
Yan Liu ◽  
Jun Zhang ◽  
Rong Zhao ◽  
Xing Zhou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Survival Analysis ◽  
Survival Rate ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Risk Group ◽  
Figo Stage ◽  
Pathological Grade ◽  
Risk Status

Abstract Endometrial cancer is one of the most common malignant tumors threatening women's health. Recently, immunity and long noncoding RNA (lncRNA) have become hot topics in oncology. Here, to search for prognostic biomarkers, immune-related lncRNAs were identified by collecting endometrial cancer samples’ information from The Cancer Genome Atlas (TCGA) database, and immune-related genes from Gene set enrichment analysis (GSEA) gene sets. These included ELN-AS1, AC103563.7, PCAT19, AF131215.5, LINC01871, AC084127.1, NRAV, SCARNA9. AL049539.1, POC1B-AS1, AC108134.4, and AC019080.5. Models based on these 12 immune-related lncRNAs were constructed. Survival analysis showed that the survival rate in the high-risk group was significantly lower than in the low-risk group. Independent prognostic analysis results showed that the patient's age, pathological grade, FIGO stage, and risk status were risk factors. Clinical correlation analysis showed that the 12 immune-related lncRNAs correlated with patients’ age, pathological grade, and FIGO stage. After principal component analysis and functional annotation, to further determine the effects of these lncRNAs on prognosis, samples were divided into training and validation groups. Multivariate Cox regression analysis of the training group showed that the patient's age, FIGO stage, and risk status were prognostic risk factors. A nomogram constructed with the risk factors was used to estimate the patient's survival rate. C-indexes were calculated and multi-index ROC curves were plotted to evaluate the accuracy and stability of the nomogram. Finally, Kaplan-Meier survival analysis showed that age, pathological grade, FIGO stage, and risk status were all related to patients’ survival. In summary, we identified 12 immune-related lncRNAs that affect the prognosis of endometrial cancer, and that may act as therapeutic targets and molecular biomarkers for the disease.

scholarly journals The Survival Effect of Ovary Preservation in Early Stage Endometrial Cancer: A Single Institution Retrospective Analysis

2020 ◽  
Author(s):  
Wonkyo Shin ◽  
Sang-Yoon Park ◽  
Sokbom Kang ◽  
Myong Cheol Lim ◽  
Sang-Soo Seo
Keyword(s):  
Endometrial Cancer ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Early Stage ◽  
Figo Stage ◽  
Factors Affecting ◽  
Chemotherapy Administration ◽  
Survival Effect ◽  
Removal Group ◽  
Early Stage Endometrial Cancer

Abstract Purpose: We investigated the effect of ovary preserving surgery in early International Federation of Obstetrics and Gynecology (FIGO) stage endometrial cancer patients.Methods: Medical records were retrospectively reviewed for 539 patients who were diagnosed with early stage endometrial cancer between Jan 2006 and Dec 2017. Patients were categorized into ovary preservation and ovary removal groups. Demographics, recurrence free survival (RFS), and five-year overall survival (OS) rate were compared, and the clinical factors affecting survival were evaluated by univariate and multivariate analysis.Results: The median follow-up period was 85 months (range, 6-142 months), and the median age was 52.7 years. The mean age was higher in the ovary removal group than in the ovary preservation group (54.4 vs 40.94 years; P < 0.001). The ovary preservation group showed an earlier FIGO stage than the ovary removal group. (P = 0.0264). There was a greater incidence of adjuvant chemotherapy administration in the removal group. There were no statistical differences in other baseline characteristics.When comparing the RFS and OS rates, there were no statistical differences between the preservation and removal groups. (recurrence free rate 98.5% vs 92.7%, p = 0.4360, and 5-year survival rate 98.6% vs 93.0%, p = 0.0892, respectively). Endometrioid histology (p=0.006) and post-operative adjuvant chemotherapy (p=0.0062) were related to OS, and adjuvant chemotherapy (p<0.001) and radiotherapy (p=0.005) were related to RFSConclusions: Ovary preservation in early stage endometrial cancer is worth considering, as it does not affect survival in early stage endometrial cancer patients

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