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2021 ◽  
Vol 6 (3) ◽  
pp. 177
Author(s):  
Muhamad Arief Hidayat

In health science there is a technique to determine the level of risk of pregnancy, namely the Poedji Rochyati score technique. In this evaluation technique, the level of pregnancy risk is calculated from the values ​​of 22 parameters obtained from pregnant women. Under certain conditions, some parameter values ​​are unknown. This causes the level of risk of pregnancy can not be calculated. For that we need a way to predict pregnancy risk status in cases of incomplete attribute values. There are several studies that try to overcome this problem. The research "classification of pregnancy risk using cost sensitive learning" [3] applies cost sensitive learning to the process of classifying the level of pregnancy risk. In this study, the best classification accuracy achieved was 73% and the best value was 77.9%. To increase the accuracy and recall of predicting pregnancy risk status, in this study several improvements were proposed. 1) Using ensemble learning based on classification tree 2) using the SVMattributeEvaluator evaluator to optimize the feature subset selection stage. In the trials conducted using the classification tree-based ensemble learning method and the SVMattributeEvaluator at the feature subset selection stage, the best value for accuracy was up to 76% and the best value for recall was up to 89.5%


2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Cristiano Miotti ◽  
Roberto Badagliacca ◽  
Carmine Dario Vizza

Abstract Aims Right ventricular function adaptation to afterload as assessed by the ratio of tricuspid annular plane excursion (TAPSE) to systolic pulmonary artery pressure (PASP) has been shown to be of prognostic relevance in pulmonary arterial hypertension (PAH). To test the hypothesis that improvement in TAPSE/PASP under targeted therapies is associated with the likelihood to achieve a better prognostic low-risk status in PAH. Methods and results The study retrospectively enrolled 677 PAH patients (55% idiopathic) with follow-up clinical, right heart catheterization, and echocardiographic evaluations within 12 months [interquartile range (IQR): 180–344 days] after initiation of targeted therapies from 2005 to 2017 in 11 Italian centres. European guidelines-derived and United States Registry to Evaluate Early and Long-Term PAH Disease Management registry REVEAL 2.0 risk scores were assessed at baseline and follow-up. The patients improved their functional class and 6-min walk distance, but a minority of them achieved or maintained the low risk status as assessed either with the European or the REVEAL 2.0 score (30% and 27%, respectively). The TAPSE/PASP ratio increased curvilinearly in proportion to decreased pulmonary vascular resistance (PVR) by more than 50%. Patients at low risk were, respectively, 4.93 and 3.37 times more likely to have TAPSE/PASP ≥0.35 mm/mmHg than those at intermediate or high risk, according to the ESC/ERS [odds ratio: (OR) 4.93, confidence interval (CI): 3.40–7.14; P = 0.0001] and the REVEAL 2.0 score (OR: 3.37, CI: 2.32–4.90; P = 0.0001). Conclusions Improvement of TAPSE/PASP under targeted therapies in PAH is associated with a low risk status, marked reduction in PVR, and improved outcome.


2021 ◽  
Vol 132 ◽  
pp. 103943
Author(s):  
Song-Shun Lin ◽  
Shui-Long Shen ◽  
Annan Zhou ◽  
Ning Zhang
Keyword(s):  

2021 ◽  
pp. 80-86
Author(s):  
E. A. Rezukhina ◽  
I. Z. Korobkova ◽  
N. M. Danilov ◽  
V. V. Gramovich ◽  
T. V. Martynyuk

Our observation demonstrates a case of a 40-year-old female with idiopathic pulmonary arterial hypertension World Health Organization functional class III, who was admitted to NMRC of Cardiology repeatedly due to disease progression including dyspnea worsening and exercise tolerance decrease after previous COVID-19 infection on riociguat (7.5 mg daily), macitentan (10 mg daily) and selexipag (1600 mcg daily) therapy. Clinical examination demonstrated high-risk status according to the expected 1-year mortality. Due to unreleased treatment goals and high-risk status, we performed transition from selexipag to inhale iloprost. After therapy escalation the patient demonstrated a significant improvement in clinical condition, dyspnea reduction and exercise tolerance increase. The current treatment strategy for pulmonary arterial hypertension is based on regular multiparametric risk stratification approach in PAH patients. The impact of COVID-19 may become an important cause of clinical worsening in PAH patients during COVID-19 pandemic. Directed on vasodilatation and antiproliferation mechanisms of action of PAH-specific drugs are supposed to be protective in COVID-19 patients. However, the probability of clinical worsening in PAH patients despite PAH-specific therapy intake needs to be closely monitored to perform timely treatment correction in order to achieve low-risk status and to improve the prognosis of PAH patients.


Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4160
Author(s):  
Diogo Sousa-Catita ◽  
Maria Alexandra Bernardo ◽  
Carla Adriana Santos ◽  
Maria Leonor Silva ◽  
Paulo Mascarenhas ◽  
...  

Nutrition is an important health issue for seniors. In nursing homes, simple, inexpensive, fast, and validated tools to assess nutritional risk/status are indispensable. A multisurvey cross-sectional study with a convenient sample was created, comparing five nutritional screening/assessment tools and the time required for each, in order to identify the most useful instrument for a nursing home setting. Nutrition risk/status was evaluated using the following tools: Subjective Global Assessment (SGA), Mini Nutritional Assessment Short Form (MNA-SF), Malnutrition Universal Screening Tool (MUST), Nutritional Risk Screening 2002 (NRS 2002), and calf girth (CG). The time spent completing each tool was recorded. Eighty-three subjects were included. MNA-SF and CG were the screening tools that ranked highest with regards to malnutrition identification. CG failed to identify nutritional risk/malnutrition in seniors with lower limb edema. CG was the fastest tool while SGA was the slowest. This was the first study comparing non-invasive nutritional tools with time expended as a consideration in the implementation. CG is responsive, fast, and reliable in elders without edema. MNA-SF was more efficient at detecting malnutrition cases in the elderly population. Both MNA-SF and CG are considered the most suitable for the nursing home setting.


2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Jianmiao Hu ◽  
Chong Chen ◽  
Kongze Zhu

The purpose is to avert the systematic financial risks from the Internet financial bubble and improve the efficiency of legal service companies’ credit risk assessment ability. Firstly, this study analyzes the commonly used classification model, Support Vector Machine (SVM), and linear regression model, Logistic model, and then puts forward the integrated SVM-Logistic + Fuzzy Multicriteria Decision-Making (FMCDM) to evaluate and analyze the credit risk level of listed companies. In the proposed integrated model, the SVM model classifies the data sample from listed companies, and the Logistic model is used for regression analysis on the credit risk assessment. Based on the credit risk indexes and weight uncertain factors of sample companies, FMCDM based on fuzzy set is applied to obtain the evaluation indexes. Then, the Analytic Hierarchy Process (AHP) is used to obtain the weight of key indexes. Finally, the fit analysis is carried out according to the existing risk status of the sample company and the risk status results of the proposed integrated model. The results show that the integrated SVM-Logistic model is complementary and has high intensive evaluation. According to the fitness value obtained by FMCDM, the company's credit risk status can be accurately evaluated, and the intermediate threshold of corporate credit default risk measurement is 0.56152; if Fit is lower than the threshold, the company’s credit is low, and if Fit is higher than the threshold, the company’s credit is high. Therefore, the data mining technology based on integrated SVM-Logistic model + FMCDM has high precision and feasible application in the credit risk assessment from legal service companies. This study creates a new method model for legal service companies in the field of corporate credit risk assessment and can provide references and ideas for corporate credit risk assessment.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xinzhu Zhou ◽  
Haozhe Li ◽  
Ce Zhu ◽  
Chao Yuan ◽  
Chunhua Meng ◽  
...  

Abstract Background Early childhood caries is an urgent public health concern. The aim of this study was to investigate salivary proteomic biomarkers for the surveillance of changes in the high-risk status of early childhood caries. The process involves the screening of specific salivary peptides that were differentially expressed only under dynamic changes in individual caries status. Methods Stimulated whole saliva samples were collected from 28 kindergarten children aged 3–4 years in Beijing at baseline and 3 months and 6 months after baseline. A total of 68 samples were collected. In terms of their caries status and progress during the observation period, participants were divided into 3 groups; 7 in the non-caries recurrence group, 6 in the caries recurrence group, and 15 in the healthy control group. Salivary peptides that exhibited no significant differences in cross-sectional comparisons between different groups of caries status but only expressed differentially along with dynamic changes of individual caries were screened using the technique of magnetic beads combined with matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS). The technique of liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) was employed to identify the proteins from which these peptides were derived. Results We found two salivary peptides differentially expressed only under dynamic changes in individual caries status in the above comparisons; mass-to-charge ratio (m/z) values of the two peptides were 1045.9 and 2517.6, respectively (P < 0.05). Principal component analysis (PCA) and the decision tree model based on these two peptides showed an acceptable distinguishing ability for changes in the high-risk status of early childhood caries. The source proteins of the two peptides with m/z values of 1045.9 and 2517.6 were identified as submandibular gland androgen regulatory protein 3B (SMR-3B) and mucin-7, respectively. Conclusions Two proteins in children’s saliva, namely SMR-3B and mucin-7, have the potentiality to serve as candidate biomarkers for dynamic surveillance of changes in high-risk status of early childhood caries.


Author(s):  
Rosily Sebastian ◽  
T. Vinaya Kumary

Background: All pregnancies are at risk even though most of the pregnancies and childbirth worldwide are uneventful. Almost 15% of all the pregnant women can develop potentially life-threatening complications which might require skilled care with some requiring major intervention for survival. Complications can occur anytime during the course of the pregnancy and childbirth, which in turn can affect the health and the overall survival of mother and the fetus. Hence there is a need to identify those high risk pregnancy groups for whom a greater degree of care is required. This study aimed to identify the risk status among antenatal mothers thus enhancing the mother to have a clear understanding about health.  Methods: A quantitative research approach with descriptive survey design was used to assess the risk status of pregnancy among antenatal mothers. The study was conducted among 100 antenatal mothers in a selected hospital, Mangaluru. Results: The present study revealed that maximum number of antenatal mothers (33.7%) were in the age group of 25-30 years and 31-36 years.41.6% antenatal mothers had high school education,24.8% had PUC education.41.6% of antenatal mothers were from nuclear family and 40.6% belongs to second trimester. The maximum number of antenatal mothers (39.6%) belongs to second gravida.75.2% of antenatal mothers belongs to above poverty line. Analysis of the association between risk statuses of pregnancy with selected demographic variables reveals that there is significant association between risk status of pregnancy with age in years and gravida status of antenatal mothers at 0.05 level of significance. In this study 55% of antenatal mothers belong to high risk pregnancy status and remaining 45% were at low risk status. Conclusion: The study reflects that most of the pregnant women are in high risk status of pregnancy. The overall findings of the study clearly showed that there is significant level of risk status of pregnancy among antenatal mothers.


CHEST Journal ◽  
2021 ◽  
Vol 160 (4) ◽  
pp. A2311-A2313
Author(s):  
Raymond Benza ◽  
Gerald Simonneau ◽  
Hossein Ghofrani ◽  
Paul Corris ◽  
Stephan Rosenkranz ◽  
...  
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