A Pilot Study Of Using Pre- And Early (1 Week) [18f]-misonidazole Positron Emission And Computed Tomography (18F-FMISO PET/CT) Scans As An Early Treatment Response Predictor In A Series Of Head and Neck Cancer (HNC) Patients Undergoing Chemoradiation

Concurrent chemoradiotherapy (CRT) is a common treatment modality for patients with advanced-stage head and neck cancer and results in high rates of locoregional disease control. Accurate assessment of disease response following completion of treatment is necessary to detect persistent disease and to direct surgical intervention if necessary.18F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) or combined PET–computed tomography (CT) has become a valuable tool in the assessment of treatment response after chemoradiotherapy. While the precise timing of the scan remains controversial, the high negative predictive value of post-treatment PET-CT strongly suggests that a complete clinical response has been achieved. The functional imaging information provided by PET-CT can be combined with the structural imaging of contrastenhanced CT or magnetic resonance imaging (MRI) and physical examination to better predict those patients who would benefit from post-treatment surgical intervention.

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Hypoxia with 18F-fluoroerythronitroimidazole integrated positron emission tomography and computed tomography (18F-FETNIM PET/CT) in locoregionally advanced head and neck cancer

Medicine ◽

10.1097/md.0000000000017067 ◽

2019 ◽

Vol 98 (40) ◽

pp. e17067 ◽

Cited By ~ 5

Author(s):

Man Hu ◽

Peng Xie ◽

Nancy Y. Lee ◽

Min Li ◽

Felix Ho ◽

...

Keyword(s):

Computed Tomography ◽

Positron Emission Tomography ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Emission Tomography ◽

Advanced Head ◽

Positron Emission ◽

Pet Ct

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Impact and prognostic value of 18F-fluorodeoxyglucose positron emission tomography-computed tomography scan in the evaluation of residual head and neck cancer: Single-center experience from Pakistan

South Asian Journal of Cancer ◽

10.4103/2278-330x.208851 ◽

2017 ◽

Vol 06 (02) ◽

pp. 081-083

Author(s):

Saima Riaz ◽

Humayun Bashir ◽

Hassan Iqbal ◽

Arif Jamshed ◽

Ahmad Murtaza ◽

...

Keyword(s):

Computed Tomography ◽

Positron Emission Tomography ◽

Head And Neck ◽

Predictive Value ◽

Fdg Pet ◽

Emission Tomography ◽

Ct Scans ◽

Positron Emission ◽

Pet Ct ◽

Fdg Pet Ct

Abstract Background: Overview of clinical impact of positron emission tomography-computed tomography (PET-CT) scans in patients with head and neck carcinomas at our center. Methods: Retrospective review of posttreatment 18F-fluorodeoxyglucose (18F-FDG) PET-CT scans in patients with head and neck carcinomas with risk of residual disease. Clinical outcome served as the reference standard. Results: This study included 93 patients (65.6% males, mean age: 48.8 years ± 17.2 standard deviation) with squamous cell carcinoma as most frequent histopathology (91.4%). PET-CT scans were performed on average 6 months posttreatment. Diagnostic accuracy, positive predictive value, and negative predictive value of PET-CT for disease were found to be 88%, 88%, and 92%, respectively. A median follow-up of 24 months was available for 91 patients. Kaplan–Meier curves showed significantly higher disease-free survival with negative PET-CT as compared to positive PET-CT (P = 0.01) and maximum standardized uptake values of <5.0 (P = 0.01). Conclusion: FDG PET-CT has diagnostic and prognostic implications in treated patient of head and neck cancers.

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Role of Positron Emission Tomography/Computed Tomography (PET/CT) in Head and Neck Cancer

Radiologic Clinics of North America ◽

10.1016/j.rcl.2013.05.002 ◽

2013 ◽

Vol 51 (5) ◽

pp. 881-893 ◽

Cited By ~ 17

Author(s):

Edward J. Escott

Keyword(s):

Computed Tomography ◽

Positron Emission Tomography ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Emission Tomography ◽

Positron Emission ◽

Pet Ct

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The Utility of Gastrointestinal Endoscopic Examination Versus Positron Emission Tomography–Computed Tomography in the Detection of Second Primary Lesions in Korean Patients With Head and Neck Cancer

Ear Nose & Throat Journal ◽

10.1177/0145561320940089 ◽

2020 ◽

pp. 014556132094008

Author(s):

Min-Su Kim ◽

In Sik Song ◽

Kyoung Ho Oh ◽

Jae-Gu Cho ◽

Seung-Kuk Baek ◽

...

Keyword(s):

Computed Tomography ◽

Positron Emission Tomography ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Endoscopic Examination ◽

Emission Tomography ◽

Positron Emission ◽

Pet Ct ◽

C Fiber

Objective: Head and neck cancer often accompany a synchronous secondary primary lesion in the digestive tract. The aim of this study was to compare detection rates between positron emission tomography–computed tomography (PET-CT) and esophagogastroduodenoscopy (G-fiber) or colonoscopy (C-fiber) in the initial staging and to analyze risk factors for premalignant, malignant, and total synchronous secondary primary lesions. Methods: A total of 739 patients with head and neck cancer who underwent PET-CT, G-fiber, or C-fiber were analyzed retrospectively. Results: Positron emission tomography–CT did not definitely detect any premalignant synchronous secondary primary lesions (0 [0%] of 739) but definitely detected 10 malignant synchronous secondary primary lesions (10 [1.35%] of 739). Esophagogastroduodenoscopy or C-fiber detected all 20 premalignant synchronous secondary primary lesions (20 [2.71%] of 739) and all 37 malignant synchronous secondary primary lesions (37 [5.00%] of 739). The patients with nasopharynx cancer tended to have premalignant synchronous secondary primary lesions (odds ratio [OR]: 3.793; 95% CI: 1.414-10.171; P = .008). Those with distant metastasis tended to have premalignant (OR: 4.743; 95% CI: 1.508-14.916; P = .009), malignant (OR: 3.803; 95% CI: 1.486-9.731; P = .005), and total synchronous secondary primary lesions (OR: 2.753; 95% CI: 1.159-6.538; P = .022). Conclusions: Premalignant or malignant synchronous secondary primary lesions that were not definitely detected by PET-CT could be found in the endoscopic examination.

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