scholarly journals Prospective Trial of Quantitative Neuroimaging Correlates of Verbal and Nonverbal Memory Decline

Author(s):  
K.R. Tringale ◽  
R. Karunamuni ◽  
T. Nguyen ◽  
T.M. Seibert ◽  
K. Leyden ◽  
...  
1996 ◽  
Vol 2 (6) ◽  
pp. 505-510 ◽  
Author(s):  
Nancy Ann Pachana ◽  
Kyle Brauer Boone ◽  
Bruce L. Miller ◽  
Jeffrey L. Cummings ◽  
Nancy Berman

AbstractNeuropsychological changes distinguishing mild Alzheimer's disease (AD) from frontotemporal dementia (FTD) have been described, but empirical verification of differential cognitive characteristics is lacking. Archival neuropsychological data on 15 FTD patients, 16 AD patients, and 16 controls were compared. Controls outperformed both patient groups on measures of verbal and nonverbal memory, executive ability, and constructional skill, with AD patients showing more widespread memory decline. No differences were found between the 3 groups in confrontation naming, recognition memory, or basic attention. Patient groups differed only in nonverbal memory, with FTD patients performing significantly better than AD patients. However, patient groups also differed in pattern of performance across executive and memory domains. Specifically, AD patients exhibited significantly greater impairment on memory than executive tasks, whereas the opposite pattern characterized ther FTD group. These findings suggest that examination of relative rankings of scores across cognitive domains, in addition to interpretation of individual neuropsychological scores, may be useful in differential diagnosis of FTD versus AD. (JINS, 1996, 2, 505–510.)


2004 ◽  
Vol 171 (4S) ◽  
pp. 304-304 ◽  
Author(s):  
Ali Tekin ◽  
Erdal Alkan ◽  
Melih Beysel ◽  
Ergin Yucebas ◽  
Ruknettin Aslan ◽  
...  

GeroPsych ◽  
2020 ◽  
Vol 33 (4) ◽  
pp. 235-244
Author(s):  
Boo Johansson ◽  
Marcus Praetorius Björk ◽  
Valgeir Thorvaldsson

Abstract. In 1987, we administered a subjective memory questionnaire to 143 40-year-old men, and 30 years later 67 of them again responded to the same questionnaire at age 70. At the follow-up, we also instructed participants to answer the questionnaire in the same manner as they thought they did at age 40 and to perform a picture recognition and a public event test. We employed confirmatory factor analysis to model a latent subjective memory construct. A single-factor solution provided acceptable model fit to data (χ2(12) = 9.33, p = .68; χ2(12) = 10.48, p = .57) and a decent reliability at both ages for the subjective memory measurements (omega = .82 and .93, respectively). Our longitudinal invariance testing revealed only a partial weak invariance. We also fitted a latent change-score model to the data. As expected, participants on average rated their memory as poorer at age 70 than at 40. Those who reported better overall health and less anxiety reported less memory decline up to age 70. Notably, this was also the case for those who rated memory as worse at age 40. Higher stress and depression at age 70, however, were associated with worse subjective memory already at age 40. The correspondences between memory ratings and tests were low. The correlation between the subjective memory factors at age 40 and 70 was 0.58, while the correlation between the memory factor at age 70 and the retrospective subjective memory factor was 0.87. Our findings suggest that subjective memory is quite consistent, and that we are inclined to preserve the continuity of our own memory functioning over the adult lifespan.


2020 ◽  
Vol 34 (6) ◽  
pp. 654-666 ◽  
Author(s):  
Erika J. Laukka ◽  
Ylva Köhncke ◽  
Goran Papenberg ◽  
Laura Fratiglioni ◽  
Lars Bäckman

2020 ◽  
Author(s):  
Francesca Farina ◽  
Marc Patrick Bennett ◽  
James William Griffith ◽  
Bert Lenaert

Evidence concerning the impact of fear of memory decline on health-related outcomes is limited. To determine the relationship between fear-avoidance of memory decline, quality of life and subjective memory in older adults using a novel scale to measure fear of memory decline. Sixty-seven older adults (59-81 years) completed a 23-item self-report questionnaire designed to capture experiential, cognitive and behavioral components of fear of memory decline, known as the fear and avoidance of memory decline (FAM) scale. Memory performance was assessed using the Wechsler Memory Scale (WMS-IV) and the Memory Failures Scale (MFS). General anxiety was assessed using the Depression, Anxiety and Stress Scales (DASS) and the Geriatric Anxiety Inventory (GAI). Quality of life was assessed using the Older Person’s Quality of Life scale (OPQOL-35). The FAM scale demonstrated good reliability and validity. Three latent factors were observed including: (1) fear-avoidance, (2) problematic beliefs and (3) resilience. After adjusting for age, education, memory performance and general anxiety, higher fear-avoidance predicted lower quality of life (p=.021) and increased memory failures (p=.022). Increased fear of memory decline predicts lower quality of life and subjective memory failures in healthy older adults. Based on these findings, we propose a preliminary fear-avoidance model that explains the development and maintenance of dementia-related functional disability in terms of psychological processes.


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