"Nrf2-AKR1C3” Positive Feedback Loop Induced the Radiation Resistance to Castration Resistant Prostate Cancer (CRPCby) Increasing the Level of Antioxidative Stress

2020 ◽  
Vol 108 (3) ◽  
pp. e504
Author(s):  
F. Lyu ◽  
X. Gao ◽  
M. Ma ◽  
M. Cui ◽  
M. Xie ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Positive Feedback ◽  
Radiation Resistance ◽  
Feedback Loop ◽  
Castration Resistant Prostate Cancer ◽  
Positive Feedback Loop ◽  
Castration Resistant ◽  
Antioxidative Stress

scholarly journals IRE1α Expedites the Progression of Castration-Resistant Prostate Cancers via the Positive Feedback Loop of IRE1α/IL-6/AR

2021 ◽  
Vol 11 ◽  
Author(s):  
Fan Yang ◽  
Chong Yuan ◽  
Dan Wu ◽  
Jing Zhang ◽  
Xingchun Zhou
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Castration Resistant Prostate Cancer ◽  
Positive Feedback Loop ◽  
Castration Resistant ◽  
Prostate Cancers

Castration-resistant prostate cancer (CRPC) is the lethal form of prostate cancer (PCa), and the underlying molecular mechanism has not been fully elucidated. Inositol requiring enzyme 1 alpha (IRE1α), a key regulator of unfolded protein response (UPR), is intimately associated with PCa progression. However, whether IRE1α is implicated in CRPC development remains unknown. Here, we showed that IRE1α expression was significantly increased in CRPC tissues and high-grade PCa tissues. Overexpression of IRE1α promoted PCa cell proliferation under the androgen deficiency condition in vitro and in vivo. Mechanistically, increased IRE1α expression induced IL-6 secretion via the IRE1α/XBP-1s signal pathway. IRE1α-induced IL-6 activated androgen receptor (AR), and the activation of AR by IL-6, in turn, promoted IRE1α expression. IRE1α formed a positive feedback loop with IL-6 and AR to promote prostate cancer cell proliferation under the androgen-deficient condition. In clinical PCa samples, high IRE1α expression correlated with elevated IL-6 and increased PSA expression. Our findings demonstrated a novel mechanism of CRPC progression and suggest targeting IRE1α may be a potential target for the prevention and treatment of CRPC.

scholarly journals Ack1-mediated Androgen Receptor Phosphorylation Modulates Radiation Resistance in Castration-resistant Prostate Cancer

2012 ◽  
Vol 287 (26) ◽  
pp. 22112-22122 ◽  
Author(s):  
Kiran Mahajan ◽  
Domenico Coppola ◽  
Bhupendra Rawal ◽  
Y. Ann Chen ◽  
Harshani R. Lawrence ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Radiation Resistance ◽  
Castration Resistant Prostate Cancer ◽  
Receptor Phosphorylation ◽  
Castration Resistant

scholarly journals CUL4B promotes prostate cancer progression by forming positive feedback loop with SOX4

Oncogenesis ◽  
2019 ◽  
Vol 8 (3) ◽  
Author(s):  
Mei Qi ◽  
Jing Hu ◽  
Yanyi Cui ◽  
Meng Jiao ◽  
Tingting Feng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Prostate Cancer Progression ◽  
Positive Feedback Loop
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