A Nested Case-Control Study of Lung Cancer for Immune Biomarkers

2022 ◽  
Vol 112 (2) ◽  
pp. e4
Author(s):  
U. Sivagnanalingam ◽  
P.L. Beatty ◽  
C. Jacqueline ◽  
M. Dracz ◽  
J. Adams-Haduch ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Immune Biomarkers ◽  
Nested Case Control ◽  
Control Study

Lung cancer risk in iron and steel foundry workers: A nested case control study in Asturias, Spain

2000 ◽  
Vol 38 (6) ◽  
pp. 644-650 ◽  
Author(s):  
Valent�n Rodr�guez ◽  
Adonina Tard�n ◽  
Manolis Kogevinas ◽  
Carlos S. Prieto ◽  
Antonio Cueto ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Lung Cancer Risk ◽  
Case Control ◽  
Iron And Steel ◽  
Nested Case Control ◽  
Foundry Workers ◽  
Control Study

Lung Cancer After Hodgkin’s Disease: A Nested Case-Control Study of the Relation to Treatment

2001 ◽  
Vol 19 (6) ◽  
pp. 1610-1618 ◽  
Author(s):  
A. J. Swerdlow ◽  
M. J. Schoemaker ◽  
R. Allerton ◽  
A. Horwich ◽  
J. A. Barber ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Hodgkin's Disease ◽  
Case Control Study ◽  
Hodgkin’S Disease ◽  
Case Control ◽  
Lung Cancers ◽  
Number Of Cycles ◽  
Nested Case Control ◽  
Control Study

PURPOSE: To investigate the causes of the raised risk of lung cancer in patients who have had Hodgkin’s disease, and in particular the relationship to treatment. PATIENTS AND METHODS: A nested case-control study was conducted within a cohort of 5,519 patients with Hodgkin’s disease treated in Britain during 1963 through 1993. For 88 cases of lung cancer and 176 matched control subjects, information on treatment and other risk factors was extracted from hospital case-notes, and odds ratios for lung cancer in relation to these factors were calculated. RESULTS: Risk of lung cancer was borderline significantly greater in patients treated with mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) chemotherapy than those who did not receive this treatment (relative risk [RR] = 1.66; 95% confidence interval [CI], 0.99 to 2.82), and increased with number of cycles of MOPP (P = .07). Exclusion of lung cancers for which histologic confirmation was not available strengthened these associations (RR = 2.41; 95% CI, 1.33 to 4.51; P = .004 for any MOPP and P = .007 for trend with number of cycles of MOPP). Risks were not raised, however, after chlorambucil, vinblastine, procarbazine, and prednisone treatment. There was evidence that the raised risk of lung cancer occurring in relation to radiotherapy was restricted to histologies other than adenocarcinoma. CONCLUSION: The results suggest that MOPP chemotherapy may lead to elevated risk of lung cancer, at least in certain subgroups of patients. The role of chemotherapy in the etiology of lung cancer after Hodgkin’s disease deserves further investigation.

The association between proton pump inhibitors (PPI) use for gastro-esophageal reflux disease (GERD) and lung cancer (LC): A nested case-control study.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 1562-1562
Author(s):  
Hadas Dresler ◽  
Daniel Keizman ◽  
Ronac Mamtani ◽  
Maya Gottfried ◽  
Natalie Maimon ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Cancer Diagnosis ◽  
Case Control Study ◽  
Lung Cancer Risk ◽  
Case Control ◽  
Sensitivity Analyses ◽  
Diagnostic Code ◽  
Nested Case Control ◽  
Control Study

1562 Background: Data suggests that GERD with recurrent reflux and microaspiration of stomach contents, may be associated with lung injury, inflammation, activation of proliferative signals, and eventually DNA damage and malignant transformation. Recently, a large population based cohort study found that GERD may increase the risk of lung cancer in Asians. In the present nested case control study, we aimed to evaluate the association between PPI use as a surrogate for GERD and lung cancer in a large western population. Methods: We conducted a matched case-control study within a population-representative database from the United Kingdom. Study cases were defined as individuals with any diagnostic code of lung cancer. For every case, four eligible controls were matched on age, gender, practice site, time and duration of follow-up. Exposure of interest was PPI use prior to cancer diagnosis. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for lung cancer were estimated using conditional logistic regression. Adjustment was performed for smoking. Results: The study population included 19143 lung cancer cases and 74473 matched controls. PPI use was associated with a significantly increased lung cancer risk (adjusted OR 1.70, 95%CI 1.64-1.77, p < 0.001). In a sensitivity analyses we observed similar associations when PPI use was initiated more than one year prior to cancer diagnosis (adjusted OR 1.18, 95%CI 1.13-1.23, p < 0.001) and more than two years prior to cancer diagnosis (adjusted OR 1.15, 95%CI 1.10-1.20, p < 0.001) Conclusions: ChronicPPI use, as a surrogate for symptomatic GERD, may be associated with a higher lung cancer risk.

scholarly journals Reanalysis of the DEMS Nested Case‐Control Study of Lung Cancer and Diesel Exhaust: Suitability for Quantitative Risk Assessment

Risk Analysis ◽  
2015 ◽  
Vol 35 (4) ◽  
pp. 676-700 ◽  
Author(s):  
Kenny S. Crump ◽  
Cynthia Van Landingham ◽  
Suresh H. Moolgavkar ◽  
Roger McClellan
Keyword(s):  
Lung Cancer ◽  
Risk Assessment ◽  
Diesel Exhaust ◽  
Case Control Study ◽  
Case Control ◽  
Quantitative Risk Assessment ◽  
Nested Case Control ◽  
Control Study

scholarly journals A nested case-control study of lung cancer among silica exposed workers in China.

1992 ◽  
Vol 49 (3) ◽  
pp. 167-171 ◽  
Author(s):  
J K McLaughlin ◽  
J Q Chen ◽  
M Dosemeci ◽  
R A Chen ◽  
S H Rexing ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Exposed Workers ◽  
Nested Case Control ◽  
Control Study
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