Is there an association between glenoid parameters and rotator cuff tears and the influence of gender: A retrospective study on a Middle Eastern population

Abstract Background The Framingham hypertension risk score is a well-known and simple model for predicting hypertension in adults. In the current study, we aimed to assess the predictive ability of this model in a Middle Eastern population. Methods We studied 5423 participants, aged 20–69 years, without hypertension, who participated in two consecutive examination cycles of the Tehran Lipid and Glucose Study (TLGS). We assessed discrimination based on Harrell’s concordance statistic (c-index) and calibration (graphical comparison of predicted vs. observed). We evaluated the original, recalibrated (for intercept and slope), and revised (for beta coefficients) models. Results Over the 3-year follow-up period, 319 participants developed hypertension. The Framingham hypertension risk score performed well in discriminating between individuals who developed hypertension and those who did not (c-index = 0.81, 95% CI: 0.79–0.83). Initially, there was a systematic underestimation of the original risk score (events predicted), which was readily corrected by a simple model revision. Conclusions The revised Framingham hypertension risk score can be used as a screening tool in public health and clinical practice to facilitate the targeting of preventive interventions in high-risk Middle Eastern people.

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Assessing oxidative stress resulting from environmental exposure to metals (Oids) in a middle Eastern population

Environmental Geochemistry and Health ◽

10.1007/s10653-021-01065-z ◽

2021 ◽

Author(s):

Ata Rafiee ◽

Juana Maria Delgado-Saborit ◽

Noel J. Aquilina ◽

Hoda Amiri ◽

Mohammad Hoseini

Keyword(s):

Oxidative Stress ◽

Environmental Exposure ◽

Middle Eastern ◽

Eastern Population ◽

Middle Eastern Population

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Molecular Characterization of Prostate Cancer in Middle Eastern Population Highlights Differences with Western Populations with Prognostic Implication

10.21203/rs.2.17590/v1 ◽

2019 ◽

Author(s):

Ramy A. Abdelsalam ◽

Ibrahim Khalifeh ◽

Alan Box ◽

Maria Kalantarian ◽

Sunita Ghosh ◽

...

Keyword(s):

Prostate Cancer ◽

Middle Eastern ◽

Genomic Alteration ◽

Published Data ◽

Lower Grade ◽

Eastern Population ◽

Western Population ◽

Pten Loss ◽

Middle Eastern Population ◽

Grade Groups

Abstract Background To investigate the incidence and prognostication of ERG, PTEN and SPINK1 protein expressions in prostate cancer cohort of Middle Eastern descent in comparison to published data from Western populationMethods Immunohistochemistry for ERG, PTEN and SPINK1 was performed in cohort of localized PCa (n=340). Data correlated to pathological and clinical outcomes and compared to Western populations.Results ERG expression and PTEN loss noted in 123/288 (42.7%) and 91/297 (30.6%) of patients, respectively. SPINK1 expression assessed in subset of cases, noted in 6/150 (4%) of patients. Only ERG expression was associated with grade groups, being more common in lower grade groups (1-3 vs 4-5; p=0.04). In contrast to Western population, PTEN loss foci were more likely to be ERG negative, observed in 81% of tumor foci and patients with PTEN neg/ERG pos were more likely to exhibit biochemical recurrence (OR 2.831; 95% CI: 1.10-726, p=0.03). This association remained significant in multivariate analysis (OR 2.68; 95% CI: 0.98-7.33, p=0.05), after adjusting for GG, path stage and surgical margin.Conclusion This study documents significant differences in key molecular events in PCa in Middle Eastern population compared to Western populations that could explain differences in PCa incidence, progression and prognostication. ERG, PTEN and SPINK1 genomic alteration occur less frequently and the enrichment of ERG for PTEN loss is not observed. Additionally, patients with combined PTEN loss/ERG positive are at highest rate for BCR vs North American Caucasian population where PTEN loss alone seems to be associated with the worst clinical outcome. The data presented here further support differences in clonal evolution between Middle Eastern and Western population in relation to PCa and add further insight to understanding PCa molecular pathways.

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702 The Role of Scapular Morphology in Traumatic Rotator Cuff Tears and Greater Tuberosity Fractures: A Retrospective Study

British Journal of Surgery ◽

10.1093/bjs/znab259.1004 ◽

2021 ◽

Vol 108 (Supplement_6) ◽

Author(s):

K de Stadler ◽

O Musbahi ◽

E Ibrahim

Keyword(s):

Retrospective Study ◽

Rotator Cuff ◽

High Reliability ◽

Outcome Measurement ◽

Area Under The Curve ◽

Rotator Cuff Tears ◽

High Morbidity ◽

Treatment Pathways ◽

Greater Tuberosity ◽

Patient Pathways

Abstract Aim Traumatic Rotator Cuff Tears(RCT) and Greater Tuberosity fractures(GT) are associated with high morbidity and reduced quality of life. Diagnostic and treatment pathways for both RCT and GT fractures are different. In this study we look at whether scapular morphology features can aid in our understanding of these traumatic injuries and influence patient pathways. Method A retrospective study was conducted at 2 hospitals. All patients between the period of 2010 and 2020 with Traumatic GT fractures or RCT were identified. Patients were case matched by age and laterality of injury. Primary outcome measurement was the Critical Shoulder Angle(CSA) and timing to further imaging. Statistical analysis was conducted using STATA™. Results Eighty patients met the inclusion criteria(40 traumatic RCT and 40 GT). Mean age was 61.8 years with 58(72.5%) left sided injuries. The difference between RCT and GT was 3.96 degrees(95% CI 2.5 to 5.41, p < 0.05). An CSA of 33.73 gave a sensitivity of 0.68 and a specificity of 0.8 to differentiate between RCT and GT fractures. The Area under the Curve(AUC) was 0.8 indicating high reliability. The overall difference in presentation to further scan between the 2 groups was 78. 3 days( P < 0.05, 95% CI 48.7 – 108). Conclusions Patients with a traumatic RCT and GT fractures have different scapular morphology and radiographic features which predisposes them to have these injuries. Patients presenting with a traumatic RCT are more likely to have a higher CSA and have a greater delay to further scan.

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