scholarly journals Malignant melanoma metastasis in the gallbladder. A case report of an unusual metastatic site

2020 ◽  
Vol 75 ◽  
pp. 372-375
Author(s):  
Gabriel Fridolin Hess ◽  
Katharina Glatz ◽  
Sacha I. Rothschild ◽  
Otto Kollmar ◽  
Savas Deniz Soysal ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Melanoma Metastasis ◽  
Metastatic Site

scholarly journals Surgical treatment of solitary malignant melanoma metastasis to the pancreas – case report and literature review

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S580-S581
Author(s):  
L. Ferreira ◽  
M. Achalandabaso ◽  
H. Alexandrino ◽  
J. Geoghegan ◽  
K. Conlon
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Malignant Melanoma ◽  
Literature Review ◽  
Melanoma Metastasis

scholarly journals A case report of Amyand hernia—radiological diagnosis and literature review

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Mohamed rafi Kathar hussain ◽  
Kulasekeran N
Keyword(s):  
Case Report ◽  
Inguinal Hernia ◽  
Malignant Melanoma ◽  
Connective Tissue ◽  
Inguinal Canal ◽  
Common Type ◽  
Melanoma Metastasis ◽  
Case Presentation ◽  
Amyand Hernia

Abstract Background The hernia is defined as the protrusion of any organ or a part of it through the wall or fascia or any connective tissue which normally encloses that organ. Among the hernias, an inguinal hernia is the most common type. In the inguinal hernia, Amyand hernia is one of the rare types, in which the appendix will herniate through the inguinal canal. The incidence of Amyand hernia is less than 1% (Namdev et al., Int Surg J 7:2072, 2020). Case presentation We are reporting a case of Amyand hernia, which was diagnosed incidentally in the patient who had been referred to computerized tomography (CT) for a malignant melanoma metastasis screening. Our case is unique in that pre-operative diagnosis of the Amyand hernia is rarely reported in the literature. We can diagnose the type 1 Amyand hernia with utmost confidence. Conclusion Pre-operative diagnosis of type 1 Amyand hernia can be made with utmost certainty by CT.

Stereotactic radiotherapy of orbital metastasis from malignant melanoma: a case study

2014 ◽  
Vol 14 (2) ◽  
pp. 208-211
Author(s):  
Wojciech Majewski ◽  
Jerzy Wydmanski ◽  
Wojciech Rokicki
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Stereotactic Radiotherapy ◽  
Negative Impact ◽  
Melanoma Metastasis ◽  
Orbital Metastasis ◽  
Orbital Cavity ◽  
Orbital Metastases

AbstractObjective:Orbital metastases lead to many distressful symptoms.Methods:A case-report of a 44-year-old woman with a melanoma metastasis in the orbital cavity, is reported. A patient presented with headache, proptosis and diplopia. The stereotactic radiotherapy of 19.5 Gy in three fractions using CyberKnife was performed. Follow-up examination 7 months later revealed satisfactory local control of the tumour, alleviation of orbital symptoms with no negative impact on visual function.Conclusion:Stereotactic radiotherapy seems to be a safe and effective treatment of orbital metastases from melanoma.

scholarly journals Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review

2017 ◽  
Vol 14 (2) ◽  
pp. 1275-1280 ◽  
Author(s):  
Saad Alqahtani ◽  
Amal Y. Alhefdhi ◽  
Osama Almalik ◽  
Ihab Anwar ◽  
Rana Mahmood ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Literature Review ◽  
Melanoma Metastasis ◽  
Oral Malignant Melanoma ◽  
The Brain

scholarly journals Symptomatic bladder metastasis of malignant melanoma: a case report

2020 ◽  
Vol 2020 (12) ◽  
Author(s):  
Rahoui Moez ◽  
Mrad Daly Khaireddine ◽  
Wajih Sahnoun ◽  
Alia Zehani ◽  
Mokhtar Bibi ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
English Literature ◽  
Rare Condition ◽  
Cutaneous Malignant Melanoma ◽  
Melanoma Metastasis ◽  
Bladder Metastasis

Abstract Bladder metastasis of cutaneous malignant melanoma is an extremely rare condition, with less than 10 cases reported in the last 30 years in the English literature. Bladder localization is most often asymptomatic, explaining the frequency of cases discovered during autopsy in multi-metastatic patients. We report a case of symptomatic malignant melanoma metastasis to the bladder in a 31-year-old patient.

Aggressive metastatic malignant melanoma of vagina: A case report

2018 ◽  
Vol 02 (01) ◽  
Author(s):  
Satyajeet Rath ◽  
Sambit Swarup Nanda ◽  
Kamal Sahni ◽  
Abhay Pratap Singh
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Metastatic Malignant Melanoma

scholarly journals Deuterium Oxide (D2O) Induces Early Stress Response Gene Expression and Impairs Growth and Metastasis of Experimental Malignant Melanoma

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 605
Author(s):  
Jana Jandova ◽  
Anh B. Hua ◽  
Jocelyn Fimbres ◽  
Georg T. Wondrak
Keyword(s):  
Gene Expression ◽  
Stress Response ◽  
Malignant Melanoma ◽  
Tumor Growth ◽  
Deuterium Oxide ◽  
Human Melanoma ◽  
Pharmacological Intervention ◽  
Melanoma Metastasis ◽  
Response Gene ◽  
Stress Response Gene

There are two stable isotopes of hydrogen, protium (1H) and deuterium (2H; D). Cellular stress response dysregulation in cancer represents both a major pathological driving force and a promising therapeutic target, but the molecular consequences and potential therapeutic impact of deuterium (2H)-stress on cancer cells remain largely unexplored. We have examined the anti-proliferative and apoptogenic effects of deuterium oxide (D2O; ‘heavy water’) together with stress response gene expression profiling in panels of malignant melanoma (A375V600E, A375NRAS, G361, LOX-IMVI), and pancreatic ductal adenocarcinoma (PANC-1, Capan-2, or MIA PaCa-2) cells with inclusion of human diploid Hs27 skin fibroblasts. Moreover, we have examined the efficacy of D2O-based pharmacological intervention in murine models of human melanoma tumor growth and metastasis. D2O-induction of apoptosis was substantiated by AV-PI flow cytometry, immunodetection of PARP-1, and pro-caspase 3 cleavage, and rescue by pan-caspase inhibition. Differential array analysis revealed early modulation of stress response gene expression in both A375 melanoma and PANC-1 adenocarcinoma cells elicited by D2O (90%; ≤6 h) (upregulated: CDKN1A, DDIT3, EGR1, GADD45A, HMOX1, NFKBIA, or SOD2 (up to 9-fold; p < 0.01)) confirmed by independent RT-qPCR analysis. Immunoblot analysis revealed rapid onset of D2O-induced stress response phospho-protein activation (p-ERK, p-JNK, p-eIF2α, or p-H2AX) or attenuation (p-AKT). Feasibility of D2O-based chemotherapeutic intervention (drinking water (30% w/w)) was demonstrated in a severe combined immunodeficiency (SCID) mouse melanoma metastasis model using luciferase-expressing A375-Luc2 cells. Lung tumor burden (visualized by bioluminescence imaging) was attenuated by D2O, and inhibition of invasiveness was also confirmed in an in vitro Matrigel transwell invasion assay. D2O supplementation also suppressed tumor growth in a murine xenograft model of human melanoma, and median survival was significantly increased without causing adverse effects. These data demonstrate for the first time that systemic D2O administration impairs growth and metastasis of malignant melanoma through the pharmacological induction of deuterium (2H)-stress.

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