Presence of detrusor muscle in bladder tumour resection: The role of operator experience

The present study was carried out to assess the possible role of ATP in the noncholinergic, nonadrenergic transmission in the rabbit urinary bladder. When rabbit detrusor muscle strips were superfused with medium containing firefly luciferin–luciferase and stimulated transmurally at low stimulation parameters, tetrodotoxin-sensitive contractions were obtained but no release of ATP could be detected. However, at somewhat higher stimulation parameters, release of ATP was observed. This release of ATP was not diminished by tetrodotoxin indicating that ATP was not likely released as a result of propagated action potentials in nerves. Because contractions persisted in the presence of tetrodotoxin, it is possible that the ATP might have been released as a result of direct electrical stimulation of the muscle. These results do not support the idea that ATP is released as a neurotransmitter in the rabbit bladder.

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Should all patients receive single chemotherapeutic agent instillation after bladder tumour resection?

BJU International ◽

10.1111/j.1464-410x.2009.08654.x ◽

2009 ◽

Vol 104 (2) ◽

pp. 170-174 ◽

Cited By ~ 25

Author(s):

Jakub Dobruch ◽

Harry Herr

Keyword(s):

Chemotherapeutic Agent ◽

Bladder Tumour ◽

Tumour Resection

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Sacral rootlet rhizotomy at the conus medullaris for hypertonic neurogenic bladder

Journal of Neurosurgery ◽

10.3171/jns.1978.48.2.0193 ◽

1978 ◽

Vol 48 (2) ◽

pp. 193-196 ◽

Cited By ~ 12

Author(s):

Stanislaw K. Toczek ◽

David C. McCullough ◽

John S. Boggs

Keyword(s):

Neurogenic Bladder ◽

Smooth Muscle Contraction ◽

Conus Medullaris ◽

Detrusor Muscle ◽

Urinary Frequency ◽

Content Type ◽

Bladder Activity ◽

Root Stimulation

✓ Three patients with spastic neurogenic bladder underwent sacral root stimulation and appropriate section of motor rootlets to the detrusor at the level of the conus medullaris. Compared to the results obtained with rhizotomies at the sacral levels in a previous series of patients, urinary frequency and infection were inhibited for longer periods of time, but some uninhibited bladder activity recurred in all three patients. Analysis of anatomical and electrophysiological data serves to emphasize the complexity and asymmetry of efferent supply to detrusor muscle. The authors conclude that the role of selective rhizotomy for inhibition of the spastic bladder is inconclusive, and perhaps a combination of surgery and medications that inhibit smooth-muscle contraction may be required for long-term protection of urinary collection systems.

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A prospective observational study to evaluate the role of restaging transurethral resection of bladder tumour in patients with non-muscle invasive bladder cancer

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20194980 ◽

2019 ◽

Vol 7 (11) ◽

pp. 4134

Author(s):

Kishan K. Raj ◽

Yogesh Taneja ◽

Prateek Ramdev ◽

Santosh K. Dhaked ◽

Charan K. Singh ◽

...

Keyword(s):

Risk Factors ◽

Transurethral Resection ◽

Prospective Observational Study ◽

Residual Disease ◽

Bladder Tumour ◽

Detrusor Muscle ◽

Residual Tumour ◽

Muscle Invasive Bladder Cancer ◽

T1 Stage ◽

Muscle Invasive

Background: Transurethral resection of bladder tumour (TURBT) is the primary treatment modality for Non-muscle invasive bladder cancer (NMIBC). Restaging transurethral resection of bladder tumour (RETURBT) is indicated to reduce risk of residual disease and correct staging errors after primary TURBT. The aim of the study is to evaluate the risk of residual tumour and upstaging in NMIBC after TURBT and to investigate the risk factors for the same.Methods: A prospective observational study was carried out over 4 years and 87 patients were included in the study. Patients with NMIBC underwent RETURBT after 2-6 weeks of primary TURBT. The incidence of residual tumour and upstaging in RETUBRT was correlated with various histopathological and morphological parameters in primary TURBT.Results: Out of 87 patients, who underwent RETURBT, residual disease was present in 51 patients (58.6%) and upstaging occurred in 22 patients (25.2%).On univariate analysis, T1 stage (p=0.01), high grade (p=0.01), Carcinoma in situ(CIS) (p=0.01) and multifocality (p=0.05) were predictive for residual disease in RETURBT. High grade (p=0.01), CIS (p=0.01) and absence of detrusor muscle in specimen (p=0.03) were risk factors for upstaging in RETURBT.Conclusions: NMIBC have high incidence of residual disease and upstaging after primary TURBT. T1 stage, high tumour grade, CIS, and multifocality are risk factors for residual disease after primary TURBT. High tumour grade, CIS and absence of detrusor muscle are strongly associated with upstaging during RETURBT.

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