Antibiotic Prophylaxis in Transurethral Prostate Resection (TURP) and Transurethral Bladder Tumour Resection (TURB)

Objectives: Transurethral bladder tumour resection (TURBT) is the common surgical method used in the diagnosis, staging and treatment of patients with bladder tumour. Most of the rare tumours other than the urothelial carcinomas of the bladder are in advanced stage on diagnosis and necessitate aggressive treatment. In our study, we aimed to the histologic types of bladder cancer and to determine the regional incidence of rare bladder cancer types in our region. Materials and methods: We retrospectively evaluated 815 patients who underwent TURBT surgery between January 2010 and March 2016 in our clinic with a diagnosis of bladder cancer and at least 1 year follow-up. Patients with tumour histopathological examination including histological tumour type, grade and were reported. Thirty-nine patients with an unclear pathology report (neighboring organ invasion, cautery artifact, etc) and 17 patients whose data could not be accessed were excluded from the study. The patients who had received chemotherapy or radiotherapy due to any type of malignancy (23) were also excluded from the study. Results: The outcomes of 736 patients operated in our clinics due to bladder tumour were evaluated. The mean age was 65.2 ± 8.4; 135 were female and 601 were male. Among them 711 patients with urothelial carcinoma were reported (94.2%). According to TNM classification, stage Ta was observed in 270 patients (37.9%), stage T1 in 297 (41.7%), and stage T2 in 144 (20.3%). Non-urothelial cancers were reported in 25 cases (3.3%). Conclusion: The incidence of bladder carcinoma varies between regions. The results of our study are similar to those of the western countries. Increased smoking and exposure to environmental carcinogenetic agents may lead to altered incidences and histological types of bladder tumours. Revision of regional tumour records may be useful to develop and evaluate future treatment strategies.

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Spinal versus General Anaesthesia in Postoperative Pain Management during Transurethral Procedures

ISRN Urology ◽

10.5402/2011/895874 ◽

2011 ◽

Vol 2011 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Stavros I. Tyritzis ◽

Konstantinos G. Stravodimos ◽

Ioanna Vasileiou ◽

Georgia Fotopoulou ◽

Georgios Koritsiadis ◽

...

Keyword(s):

Postoperative Pain ◽

General Anaesthesia ◽

Analogue Scale ◽

Bladder Tumour ◽

Analgesic Efficacy ◽

Postoperative Pain Management ◽

Tumour Volume ◽

Tumour Resection ◽

Transurethral Prostatectomy ◽

Vas Score

We compared the analgesic efficacy of spinal and general anaesthesia following transurethral procedures. 97 and 47 patients underwent transurethral bladder tumour resection (TUR-B) and transurethral prostatectomy (TUR-P), respectively. Postoperative pain was recorded using an 11-point visual analogue scale (VAS). VAS score was greatest at discharge from recovery room for general anaesthesia (). The pattern changed significantly at 8 h and 12 h for general anaesthesia's efficacy ( and resp.). A higher VAS score was observed in pT2 patients. Patients with resected tumour volume >10 exhibited a VAS score >3 at 8 h and 24 h (, resp.). Multifocality of bladder tumours induced more pain overall. It seems that spinal anaesthesia is more effective during the first 2 postoperative hours, while general prevails at later stages and at larger traumatic surfaces. Finally, we incidentally found that tumour stage plays a significant role in postoperative pain, a point that requires further verification.

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The effect of intraoperative dexmedetomidine on postoperative catheter-related bladder discomfort in patients undergoing transurethral bladder tumour resection

European Journal of Anaesthesiology ◽

10.1097/eja.0000000000000196 ◽

2015 ◽

Vol 32 (9) ◽

pp. 596-601 ◽

Cited By ~ 23

Author(s):

Hyun-Chang Kim ◽

Yong-Hun Lee ◽

Young-Tae Jeon ◽

Jung-Won Hwang ◽

Young-Jin Lim ◽

...

Keyword(s):

Bladder Tumour ◽

Tumour Resection

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V1879 EN-BLOC (SAND WEDGE) BLADDER TUMOUR RESECTION

The Journal of Urology ◽

10.1016/j.juro.2011.02.1982 ◽

2011 ◽

Vol 185 (4S) ◽

Author(s):

Amit Patel ◽

Barnaby Chappell ◽

Dan Wilby ◽

Kay Thomas ◽

Tim O'Brien

Keyword(s):

Bladder Tumour ◽

Tumour Resection ◽

En Bloc

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A rare case of aggressive squamous cell carcinoma of the bladder in pregnancy

Obstetric Medicine ◽

10.1258/om.2012.120021 ◽

2013 ◽

Vol 6 (4) ◽

pp. 182-183 ◽

Cited By ~ 2

Author(s):

E Church ◽

A Dieh

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Rare Case ◽

Bladder Tumour ◽

Renal Dialysis ◽

Tumour Resection ◽

Carcinoma Of The Bladder ◽

Tract Infections ◽

In Pregnancy

We report a rare case of an aggressive squamous cell carcinoma of the bladder in a young primigravid woman with recurrent urinary tract infections and microscopic haematuria. An emergency caesarean section was performed at 37 weeks gestation for suspected placental abruption; however, she was found to have frank haematuria. Postnatally, an advanced bladder tumour was diagnosed. She required renal dialysis, a radical cystectomy and radiotherapy but sadly died seven months after diagnosis. This case illustrates the importance of thorough investigation of haematuria in pregnancy. Cystoscopy and even tumour resection can be safely performed in pregnancy. Although squamous cell carcinomas account for only 2% of bladder tumours in developed countries, they tend to be large and deeply invasive, requiring radical surgery and chemotherapy or radiotherapy. Management should be multidisciplinary and treatment individualized due to the significant clinical and emotional challenges which arise when a woman develops a malignancy in pregnancy or the puerperium.

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A pilot study of urinary microRNA as a biomarker for urothelial cancer

Canadian Urological Association Journal ◽

10.5489/cuaj.278 ◽

2013 ◽

Vol 7 (1-2) ◽

pp. 28 ◽

Cited By ~ 30

Author(s):

Jaime Snowdon ◽

Sandy Boag ◽

Harriet Feilotter ◽

Jason Izard ◽

D. Robert Siemens

Keyword(s):

Bladder Cancer ◽

Pilot Study ◽

Urothelial Cancer ◽

Bladder Tumour ◽

Fold Increase ◽

Urine Samples ◽

Tumour Resection ◽

Cancer Tissue ◽

High Grade ◽

Tissue Samples

Objective: MicroRNAs (miRNAs) are part of a class of small ribonucleic acid (RNAs). They are important regulatory molecules, involved in several cell processes, such as developmental timing, stem cell division and apoptosis. Dysregulated miRNAs have been identified in several human malignancies, including bladder cancer tissue samples, and may confer a “tumour signature” that can be exploited for diagnostic purposes. We report on a prospective pilot study investigating the diagnostic capability of miRNAs in the urine of patients with urothelial cancer.Methods: Voided urine samples were collected from patients with urothelial carcinoma just prior to bladder tumour resection, as well as age-matched healthy control patients. Pathology demonstrated both low- and high-grade cancer. Total RNA was isolated and quantitative reverse transcriptase-polymerase chain reaction was performed on the RNA extracts using primers for 4 miRNAs shown previously to be dysregulated in solid urothelial carcinomas with RNU6B as the endogenous control. Standard urine cytology was performed on all samples in a blinded fashion.Results: Two miRNAs of interest were dysregulated in the urine from cancer patients with miR-125b showing an average 10.42-fold decrease (p < 0.01) and miR-126 showing an average 2.70-fold increase (p = 0.30) in the cancer samples compared to the normal controls. The sensitivity and specificity of the cytology on the same urine samples were 50% and 80%, respectively. Using these 2miRNAs only, a decision-tree prediction model was generated for a validation cohort of patients yielding a specificity of 100% and a sensitivity of 80%.Discussion: This preliminary study of candidate urinary miRNA inpatients with low- and high-grade urothelial cancer demonstrated a significantly improved diagnostic accuracy over cytology. These results provide rationale for further studies on discovery and validation of candidate miRNAs in voided urine and may potentially lead to the development of a non-invasive and sensitive test for bladder cancer diagnosis and prognosis.

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