An Invited Commentary “Prognostic effect of the new 5-factor modified frailty index in patients undergoing carotid endarterectomy with regional anesthesia - A prospective cohort study”

2020 ◽  
Vol 81 ◽  
pp. 130-131
Author(s):  
Hualei Chen ◽  
Julius Wedam Atogebania
Keyword(s):  
Cohort Study ◽  
Carotid Endarterectomy ◽  
Regional Anesthesia ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Frailty Index ◽  
Prognostic Effect ◽  
Modified Frailty Index

scholarly journals Retrojugular approach for carotid endarterectomy: A prospective cohort study

2002 ◽  
Vol 35 (4) ◽  
pp. 737-740 ◽  
Author(s):  
H.A. Safar ◽  
B. Doobay ◽  
G. Evans ◽  
K. Kazemi ◽  
A. Jahromi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Carotid Endarterectomy ◽  
Prospective Cohort Study ◽  
Prospective Cohort

scholarly journals Association between clinical frailty, illness severity and post-discharge survival: a prospective cohort study of older medical inpatients in Norway

2021 ◽  
Author(s):  
Andreas Engvig ◽  
Torgeir Bruun Wyller ◽  
Eva Skovlund ◽  
Marc Vali Ahmed ◽  
Trygve Sundby Hall ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Frailty Index ◽  
Illness Severity ◽  
Cox Proportional Hazards Model ◽  
Early Warning Score ◽  
Post Discharge ◽  
Medical Wards ◽  
The Impact

Abstract Purpose Study associations between frailty, illness severity and post-discharge survival in older adults admitted to medical wards with acute clinical conditions. Methods Prospective cohort study of 195 individuals (mean age 86; 63% females) admitted to two medical wards with acute illness, followed up for all-cause mortality for 20 months after discharge. Ward physicians screened for frailty and quantified its degree from one to eight using Clinical Frailty Scale (CFS), while clinical illness severity was estimated by New Early Warning Score 2 (NEWS2) and laboratory illness severity was calculated by a frailty index (FI-lab) using routine blood tests. Results CFS, NEWS2 and FI-lab scores were independently associated with post-discharge survival in an adjusted Cox proportional hazards model with age, ward category (acute geriatric and general medical) and comorbidity as covariates. Adjusted hazard ratios and 95% confidence intervals were 1.54 (1.24–1.91) for CFS, 1.12 (1.03–1.23) for NEWS2, and 1.02 (1.00–1.05) for FI-lab. A frailty × illness severity category interaction effect (p = 0.003), suggested that the impact of frailty on survival was greater in those experiencing higher levels of illness severity. Among patients with at least moderate frailty (CFS six to eight) and high illness severity according to both NEWS2 and FI-lab, two (13%) were alive at follow-up. Conclusion Frailty screening aided prognostication of survival following discharge in older acutely ill persons admitted to medical wards. The prognostic value of frailty increased when combined with readily available illness severity markers acquired during admission.

The cumulative effect of frailty and cognition on mortality – results of a prospective cohort study

2016 ◽  
Vol 29 (4) ◽  
pp. 535-543 ◽  
Author(s):  
Philip D. St. John ◽  
Suzanne L. Tyas ◽  
Lauren E. Griffith ◽  
Verena Menec
Keyword(s):  
Cohort Study ◽  
Cognitive Impairment ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Proportional Hazards ◽  
Reference Group ◽  
Frailty Index ◽  
Cox Proportional Hazards ◽  
Cognitively Impaired ◽  
Gender And Education

ABSTRACTBackground:Both physical frailty and cognitive impairment predict death, but the joint effect of these two factors is uncertain. The objectives are to determine if the Mini-mental state examination (MMSE) and the Frailty Index (FI) predict death over a five-year interval after accounting for the effect of the other; and if there is an interaction in this effect.Methods:An analysis of an existing prospective cohort study of 1,751 community living older adults followed over a five-year time frame. Age, gender, and education were self-reported. The predictor variables were the FI – a measure of frailty based on the “Accumulation of Deficits” model of frailty; and the MMSE. Cox proportional hazards models were constructed for the outcome of time to death.Results:The unadjusted Hazard Ratio (HR) (95% CI) for mortality was 2.17 (1.69, 2.80) for those who were only cognitively impaired, 2.02 (1.53, 2.68) for those who were only frail, and 3.57 (2.75, 4.62) for those who were both frail and cognitively impaired with the reference group of those who were neither frail nor cognitively impaired. Adjusted for age, gender, and education, the HR (95% CI) was 1.49 (1.13. 1.95) for those who were only cognitively impaired, 1.81 (1.35, 2.41) for those who were only frail, and 2.28 (1.69, 3.09) for those who were both frail and cognitively impaired.Conclusions:Both frailty and cognitive impairment are predictors of mortality and the effect is cumulative. There was no interaction in this effect.

scholarly journals Frailty index and all-cause and cause-specific mortality in Chinese adults: a prospective cohort study

2020 ◽  
Vol 5 (12) ◽  
pp. e650-e660 ◽  
Author(s):  
Junning Fan ◽  
Canqing Yu ◽  
Yu Guo ◽  
Zheng Bian ◽  
Zhijia Sun ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Frailty Index ◽  
Chinese Adults ◽  
Specific Mortality

scholarly journals Prospective cohort study examining the use of regional anesthesia for early pain management after combat-related extremity injury

2019 ◽  
pp. rapm-2019-100773 ◽  
Author(s):  
Rollin M Gallagher ◽  
Rosemary C Polomano ◽  
Nicholas A Giordano ◽  
John T Farrar ◽  
Wensheng Guo ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Cohort Study ◽  
Pain Management ◽  
Pain Relief ◽  
Pain Intensity ◽  
Regional Anesthesia ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Extremity Injury ◽  
Average Pain

BackgroundNo studies have examined the long-term benefits of regional anesthesia (RA) for pain management after combat-related injury. The objective of this prospective cohort study was to examine the relationship between RA administration and patient-reported pain-related outcomes among Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) service members sustaining a combat-related extremity injury.MethodsBetween 2007 and 2013, n=358 American military personnel injured in OEF/OIF were enrolled at two military treatment facilities. Individuals were followed for up to 2 years after injury. Cohorts were defined based on whether participants were administered RA within 7 days after sustaining a combat-related injury, or not. Linear mixed effects models examined the association between RA and average pain intensity. Secondary outcomes included pain relief, pain interference, neuropathic pain symptoms, treatment outcomes related to pain management, and mental health symptoms.ResultsReceiving early RA was associated with improved average pain over the first 6 months after injury (β=−0.57; p=0.012) adjusting for injury severity and length of stay at the primary treatment facility. This difference was observed up to 24 months after injury (β=−0.36; p=0.046). Individuals receiving early RA reported greater pain relief, improved neuropathic pain intensity, and higher satisfaction with pain outcomes; however, by 24 months, mean scores did not significantly differ between cohorts.ConclusionFindings indicate that when administered soon after traumatic injury, RA is a valuable pain management intervention. Future longitudinal studies investigating the timely delivery of RA for optimal pain management in civilian trauma settings are needed.Trial registration numberNCT00431847

Organizational Justice and Health of Employees: Prospective Cohort Study.

2013 ◽  
Author(s):  
Mika Kivimaki ◽  
Marko Elovainio ◽  
Jussi Vahtera ◽  
Marianna Virtanen ◽  
Jane E. Ferrie
Keyword(s):  
Cohort Study ◽  
Organizational Justice ◽  
Prospective Cohort Study ◽  
Prospective Cohort
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