A high fraction of inspired oxygen may increase mortality in intubated trauma patients – A retrospective cohort study

Injury ◽  
2021 ◽  
Author(s):  
Josefine S. Baekgaard ◽  
Volkert Siersma ◽  
Rasmus Ejlersgaard Christensen ◽  
Camilla Ikast Ottosen ◽  
Katrine Bennett Gyldenkærne ◽  
...  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
E. ter Avest ◽  
J. Griggs ◽  
J. Wijesuriya ◽  
M. Q. Russell ◽  
R. M. Lyon

2019 ◽  
Vol 29 (12) ◽  
pp. 1598-1604
Author(s):  
Arianne T. Train ◽  
Hibbit-Ur-Rauf Naseem ◽  
Ziquiang Chen ◽  
Gregory E. Wilding ◽  
Kathryn D. Bass ◽  
...  

2021 ◽  
Vol 6 (1) ◽  
pp. e000694
Author(s):  
Takeshi Nishimura ◽  
Hiromichi Naito ◽  
Atsunori Nakao ◽  
Shinichi Nakayama

PurposeSelf-inflicted injury is one of the most common causes of suicide. Extremity injury is thought to occur most frequently among penetrating injury; however, epidemiology among patients attempting suicide is unknown. This study aims to find the characteristics of penetrating self-inflicted trauma patients.MethodsThis is a retrospective cohort study of Japanese nation-wide trauma registry (the Japan National Trauma Data Bank) between January 1, 2004 and December 31, 2017. Patients who attempted suicide with penetrating injury were eligible. We evaluated the occurrence of injury based on injury site (neck/face, chest, abdomen, extremity) as a dependent variable and aging as an independent variable using a generalized linear model and compare those groups with spline models.Results4576 trauma patients were eligible. Excluding patients with missing age, missing survival data, and missing abbreviate injury score, 4183 patients were enrolled in this study. Common injury site is follows: abdomen 1772 patients (42.4%), extremity 1344 patients (32.0%), neck/face 1253 patients (30.0%), and chest 993 patients (23.7%). The occurrence of neck/face injury, chest injury, and abdominal injury increased with age. On contrary, the rate of extremity injury decreased with age.ConclusionsAmong self-inflicted trauma patients, abdominal injury was the most common injury, and neck/face injury, chest injury, and abdominal injury were related with aging. On the contrary, the rate of extremity injury decreased as patients’ age progressed.Level of evidenceRetrospective cohort study, Level III.


Author(s):  
Vasileia Nyktari ◽  
◽  
Helen Diamantaki ◽  
Georgios Stefanakis ◽  
Emmanouela Koutoulaki ◽  
...  

Objectives: This study aims to clarify the role of prophylactic TXA on blood loss and transfusion requirements in a subgroup of trauma patients undergoing major orthopaedic surgery on a non-urgent basis. Study design: This is a retrospective cohort study Setting: Tertiary University Hospital of Crete (2017-2018) Patients/participants: Polytrauma patients who underwent delayed major orthopaedic surgery Main outcome measurement: Significant haemorrhage occurrence in relation to TXA administration. In a subgroup of patients Rotational Thromboelastometry (ROTEM) was used to reveal their haemostatic profile prior to TXA administration. Methods: Data from anaesthetic and ICU records were analyzed regarding age, sex, body mass index, ASA physical status, Injury Severity Score, Caprini Score, intraoperative blood loss, number of packed red blood cells units transfused, volume of crystalloids administered, operation duration, preoperative and postoperative haemoglobin values, and days from hospital admission to surgery. ROTEM analysis in a subgroup of patients revealed their haemostatic profile prior to TXA administration. Results: Twenty five out of 46 patients received prophylactic TXA treatment. After adjustment for confounding factors, the odds ratio for the composite endpoint for prophylactic TXA (n=25) vs no TXA (n=21) was 1.27 (95% confidence interval, CI 0.39-4.16). Propensity matched analysis confirmed the absence of a difference between patients with and without TXA. In all patients analyzed with ROTEM normal or hypercoagulable status was revealed. Conclusions: In trauma patients undergoing major orthopaedic surgery more than 12 hours after the initial injury, TXA has no effect on blood loss and transfusion requirements. Keywords: tranexamic acid; blood loss; transfusion; orthopaedic trauma surgery; spine surgery; pelvis surgery; significant bleeding in orthopaedic surgery


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