scholarly journals The effect of tranexamic acid on blood loss in non-urgent trauma patients undergoing major orthopaedic surgery: A retrospective cohort study

2021 ◽  
Vol 2 (6) ◽  
Author(s):  
Vasileia Nyktari ◽  
◽  
Helen Diamantaki ◽  
Georgios Stefanakis ◽  
Emmanouela Koutoulaki ◽  
...  
Keyword(s):  
Cohort Study ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Orthopaedic Surgery ◽  
Trauma Surgery ◽  
Trauma Patients ◽  
Transfusion Requirements ◽  
Major Orthopaedic Surgery

Objectives: This study aims to clarify the role of prophylactic TXA on blood loss and transfusion requirements in a subgroup of trauma patients undergoing major orthopaedic surgery on a non-urgent basis. Study design: This is a retrospective cohort study Setting: Tertiary University Hospital of Crete (2017-2018) Patients/participants: Polytrauma patients who underwent delayed major orthopaedic surgery Main outcome measurement: Significant haemorrhage occurrence in relation to TXA administration. In a subgroup of patients Rotational Thromboelastometry (ROTEM) was used to reveal their haemostatic profile prior to TXA administration. Methods: Data from anaesthetic and ICU records were analyzed regarding age, sex, body mass index, ASA physical status, Injury Severity Score, Caprini Score, intraoperative blood loss, number of packed red blood cells units transfused, volume of crystalloids administered, operation duration, preoperative and postoperative haemoglobin values, and days from hospital admission to surgery. ROTEM analysis in a subgroup of patients revealed their haemostatic profile prior to TXA administration. Results: Twenty five out of 46 patients received prophylactic TXA treatment. After adjustment for confounding factors, the odds ratio for the composite endpoint for prophylactic TXA (n=25) vs no TXA (n=21) was 1.27 (95% confidence interval, CI 0.39-4.16). Propensity matched analysis confirmed the absence of a difference between patients with and without TXA. In all patients analyzed with ROTEM normal or hypercoagulable status was revealed. Conclusions: In trauma patients undergoing major orthopaedic surgery more than 12 hours after the initial injury, TXA has no effect on blood loss and transfusion requirements. Keywords: tranexamic acid; blood loss; transfusion; orthopaedic trauma surgery; spine surgery; pelvis surgery; significant bleeding in orthopaedic surgery

scholarly journals The effect of tranexamic acid on blood loss and maternal outcome in the treatment of persistent postpartum hemorrhage: A nationwide retrospective cohort study

PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0187555 ◽  
Author(s):  
Ada Gillissen ◽  
Dacia D. C. A. Henriquez ◽  
Thomas van den Akker ◽  
Camila Caram-Deelder ◽  
Merlijn Wind ◽  
...  
Keyword(s):  
Cohort Study ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Retrospective Cohort Study ◽  
Postpartum Hemorrhage ◽  
Retrospective Cohort ◽  
Maternal Outcome

A high fraction of inspired oxygen may increase mortality in intubated trauma patients – A retrospective cohort study

Injury ◽  
2021 ◽  
Author(s):  
Josefine S. Baekgaard ◽  
Volkert Siersma ◽  
Rasmus Ejlersgaard Christensen ◽  
Camilla Ikast Ottosen ◽  
Katrine Bennett Gyldenkærne ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Trauma Patients ◽  
High Fraction ◽  
Fraction Of Inspired Oxygen ◽  
Inspired Oxygen

scholarly journals Determinants of prehospital lactate in trauma patients: a retrospective cohort study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
E. ter Avest ◽  
J. Griggs ◽  
J. Wijesuriya ◽  
M. Q. Russell ◽  
R. M. Lyon
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Trauma Patients

Post-Tonsillectomy Hemorrhage Control with Nebulized Tranexamic Acid: A Retrospective Cohort Study

2021 ◽  
pp. 110802
Author(s):  
Dylan Z. Erwin ◽  
Philip D. Heichel ◽  
Laura M. Wright ◽  
Nira A. Goldstein ◽  
Timothy P. McEvoy ◽  
...  
Keyword(s):  
Cohort Study ◽  
Tranexamic Acid ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Hemorrhage Control

scholarly journals Comparison Between Bilateral Simultaneous Total Hip Arthroplasty With and Without Drainage; a Retrospective Cohort Study

2021 ◽  
Author(s):  
Min-Gwang Kim ◽  
Taek-Rim Yoon ◽  
Kyung-Soon Park
Keyword(s):  
Cohort Study ◽  
Blood Loss ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Postoperative Bleeding ◽  
Total Blood Loss ◽  
Postoperative Blood Loss ◽  
Consecutive Series ◽  
Transfusion Rate ◽  
Total Blood

Abstract BackgroundThere are many reports staged bilateral THA without drainage is a better method than with drainage in many ways. However, there is little report regarding bilateral simultaneous THA (BSTHA) without drainage. This study aimed to evaluate the differences in the clinical outcomes and complication rate of BSTHA with drainage and without drainage.MethodsBetween October 2015 and April 2019, a retrospective cohort study was conducted with modified minimally invasive two-incision method and a consecutive series of 41 BSTHA performed with drainage were compared to 37 BSTHA performed without drainage. It was assessed clinically and radiographically for a mean of 2.1 ± 0.8 years (range, 1.0-4.8 years). Postoperative hematologic values (Hgb drop, Hct drop, total blood loss, transfusion rate), pain susceptibility, functional outcome, and complication were compared in the drained group and the non-drained group. All patients preoperatively received intravenous tranexamic acid (TXA) and intraoperatively received intra-articular TXA on each hip. Statistical analyses were performed using the independent t tests, Chi-squared or Fisher’s exact tests. A significance level of ≤ 0.05 was used for all statistical tests.Results Mean postoperative Hgb (g/dL, p < 0.001) & Hct drop (%, p < 0.001), mean total blood loss (ml, p < 0.001) and mean transfusion unit (IU, p < 0.001) were significantly lower in the BSTHA without drainage than in the BSTHA with drainage group. But the mean dose of morphine equivalent (mg, p < 0.001) was significantly larger in BSTHA without drainage.ConclusionBSTHA without drainage can reduce postoperative blood loss and the requirement for transfusion without increasing other complication. But BSTHA without drainage is more painful method than BSTHA with drainage. Therefore, BSTHA without drainage will be a good option to reduce the burden on the patient by reducing postoperative bleeding if it can control pain well after surgery.

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