Effect of intranasal administration of Lactobacillus pentosus S-PT84 on influenza virus infection in mice

2010 ◽  
Vol 10 (9) ◽  
pp. 1101-1106 ◽  
Author(s):  
Takayuki Izumo ◽  
Toshihiro Maekawa ◽  
Masayuki Ida ◽  
Akane Noguchi ◽  
Yoshinori Kitagawa ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Intranasal Administration ◽  
Influenza Virus Infection ◽  
Lactobacillus Pentosus

Oral administration of heat-killed Lactobacillus pentosus strain b240 augments protection against influenza virus infection in mice

2011 ◽  
Vol 11 (2) ◽  
pp. 199-203 ◽  
Author(s):  
Noritada Kobayashi ◽  
Takao Saito ◽  
Takayuki Uematsu ◽  
Kazumasa Kishi ◽  
Masamichi Toba ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Oral Administration ◽  
Influenza Virus Infection ◽  
Lactobacillus Pentosus

Cross-protection against influenza virus infection by intranasal administration of M2-based vaccine with chitosan as an adjuvant

2010 ◽  
Vol 155 (4) ◽  
pp. 535-544 ◽  
Author(s):  
Zhiwei Sui ◽  
Quanjiao Chen ◽  
Rui Wu ◽  
Hongbo Zhang ◽  
Mei Zheng ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Intranasal Administration ◽  
Influenza Virus Infection ◽  
Cross Protection

Protection against influenza virus infection by intranasal administration of C3d-fused hemagglutinin

Vaccine ◽  
2003 ◽  
Vol 21 (31) ◽  
pp. 4532-4538 ◽  
Author(s):  
Izumi Watanabe ◽  
Ted M. Ross ◽  
Shin-ichi Tamura ◽  
Takeshi Ichinohe ◽  
Satoshi Ito ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Intranasal Administration ◽  
Influenza Virus Infection

Intranasal administration of live Lactobacillus species facilitates protection against influenza virus infection in mice

2012 ◽  
Vol 93 (1) ◽  
pp. 138-143 ◽  
Author(s):  
Ha-Na Youn ◽  
Dong-Hun Lee ◽  
Yu-Na Lee ◽  
Jae-Keun Park ◽  
Seong-Su Yuk ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Intranasal Administration ◽  
Influenza Virus Infection ◽  
Lactobacillus Species

Protection against influenza virus infection by intranasal administration of hemagglutinin vaccine with chitin microparticles as an adjuvant

2004 ◽  
Vol 75 (1) ◽  
pp. 130-136 ◽  
Author(s):  
Hideki Hasegawa ◽  
Takeshi Ichinohe ◽  
Peter Strong ◽  
Izumi Watanabe ◽  
Satoshi Ito ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Intranasal Administration ◽  
Influenza Virus Infection

scholarly journals Effect of Intranasal Administration ofLactobacillus casei Shirota on Influenza Virus Infection of Upper Respiratory Tract in Mice

2001 ◽  
Vol 8 (3) ◽  
pp. 593-597 ◽  
Author(s):  
Tetsuji Hori ◽  
Junko Kiyoshima ◽  
Kan Shida ◽  
Hisako Yasui
Keyword(s):  
Influenza Virus ◽  
Survival Rate ◽  
Virus Infection ◽  
Respiratory Tract ◽  
Intranasal Administration ◽  
Control Level ◽  
Influenza Virus Infection ◽  
Control Group ◽  
Upper Respiratory Tract ◽  
Upper Respiratory

ABSTRACT In mice administered Lactobacillus casei strain Shirota (LcS) intranasally, potent induction of interleukin 12, gamma interferon, and tumor necrosis factor alpha, which play a very important role in excluding influenza virus (IFV), was evident in mediastinal lymph node cells. In this model of upper respiratory IFV infection, the titers of virus in the nasal wash of mice inoculated with 200 μg of LcS for three consecutive days (LcS 200 group) before infection were significantly (P < 0.01) lower than those of mice not inoculated with LcS (control group) (100.9 ± 0.6 versus 102.1 ± 1.0). The IFV titer was decreased to about 1/10 of the control level. Using this infection model with modifications, we investigated whether the survival rate of mice was increased by intranasal administration of LcS. The survival rate of the mice in the LcS 200 group was significantly (P < 0.05) greater than that of the mice in the control group (69% versus 15%). It seems that the decrease in the titer of virus in the upper respiratory tract to 1/10 of the control level was important in preventing death. These findings suggest that intranasal administration of LcS enhances cellular immunity in the respiratory tract and protects against influenza virus infection.

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