Exogenous ghrelin ameliorates acute lung injury by modulating the nuclear factor κB inhibitor kinase/nuclear factor κB inhibitor/nuclear factor κB pathway after hemorrhagic shock

2019 ◽  
Vol 69 ◽  
pp. 95-102 ◽  
Author(s):  
Li-Na Zhang ◽  
Wei-Dong Gong ◽  
Juan Luo ◽  
Yong-Jing Yu ◽  
Si-Hua Qi ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Hemorrhagic Shock ◽  
Nuclear Factor Κb ◽  
Nuclear Factor

6-Gingerol Ameliorates Sepsis Induced Acute Lung Injury by Regulating Nuclear Factor-κB and Nuclear-Factor Erythroid 2-Related Factor 2/Heme Oxygenase-1 Signaling Pathways

2020 ◽  
Vol 19 (3) ◽  
pp. 255-260
Author(s):  
Fan Yang ◽  
Lu Deng ◽  
MuHu Chen ◽  
Ying Liu ◽  
Jianpeng Zheng
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Heme Oxygenase ◽  
Interleukin 1 ◽  
Nuclear Factor Κb ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Nuclear Factor ◽  
Alveolar Collapse ◽  
Factor Α

Acute lung injury initiated systemic inflammation leads to sepsis. Septic mice show a series of degenerative changes in lungs as demonstrated by pulmonary congestion, alveolar collapse, inflammatory cell infiltration, and increased wet-todry weight in lungs. 6-Gingerol ameliorates histopathological changes and clinical outcome of the sepsis. The increase in the levels of tumor necrosis factor-α, interleukin-1 beta, interleukin-6, and interleukin-18 in septic mice were reduced by administration with 6-Gingerol. Also, 6-Gingerol attenuates sepsis-induced increase of malonaldehyde and decrease of catalase, superoxide, and glutathione. Enhanced phospho-p65, reduced nuclear factor erythropoietin-2-related factor 2, and heme oxygenase 1 in septic mice were reversed by administration with 6-Gingerol. In conclusion, 6-Gingerol demonstrates anti-inflammatory and antioxidant effects against sepsis associated acute lung injury through inactivation of nuclear factor-kappa B and activation of nuclear-factor erythroid 2-related factor 2 pathways.

scholarly journals Vitamin K3 attenuates lipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-κB activation

2009 ◽  
Vol 160 (2) ◽  
pp. 283-292 ◽  
Author(s):  
S. Tanaka ◽  
S. Nishiumi ◽  
M. Nishida ◽  
Y. Mizushina ◽  
K. Kobayashi ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Vitamin K3

Apocynin suppressed the nuclear factor-κB pathway and attenuated lung injury in a rat hemorrhagic shock model

2017 ◽  
Vol 82 (3) ◽  
pp. 566-574 ◽  
Author(s):  
Seok Ho Choi ◽  
Gil Joon Suh ◽  
Woon Yong Kwon ◽  
Kyung Su Kim ◽  
Min Ji Park ◽  
...  
Keyword(s):  
Lung Injury ◽  
Hemorrhagic Shock ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Shock Model ◽  
Hemorrhagic Shock Model

SEVERITY OF LUNG INJURY IS AGE-DEPENDENT AND IS REGULATED BY NUCLEAR FACTOR-κB (NF-κB) IN HEMORRHAGIC SHOCK.

Shock ◽  
2004 ◽  
Vol 21 ◽  
pp. 24
Author(s):  
Timothy J. Burroughs ◽  
Paul W. Hake ◽  
Michael OʼConnor ◽  
Basilia Zingarelli
Keyword(s):  
Lung Injury ◽  
Hemorrhagic Shock ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Age Dependent

scholarly journals MicroRNA‑21 inhibits lipopolysaccharide‑induced acute lung injury by targeting nuclear factor‑κB

2018 ◽  
Author(s):  
Wei‑Dong Zhu ◽  
Jia Xu ◽  
Mao Zhang ◽  
Tie‑Ming Zhu ◽  
Yun‑Hua Zhang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Nuclear Factor Κb ◽  
Nuclear Factor
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